Results 221 to 230 of about 243,077 (307)

Evaluation of in vitro and in vivo antidiabetic potential of hydromethanol extract and solvent fraction of the leaves of <i>Ajuga integrifolia</i> (Lamiaceae) in diabetic mice models. [PDF]

Metabol Open
Daba Y, Kitessa M, Ahmed K, Million D, Temesgen A, Amde M, Kiros T, Walo D, Belayneh A, Abdela J.   +9 more
europepmc   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

First comprehensive GC-MS profile of Echinops erinaceus with antimicrobial and cytotoxic activities and in-silico model. [PDF]

Sci Rep
Sweilam SH, Awaad AS, Said MA, Foudah AI, Alqarni MH, Aljarba TM, El-Sherei MM, Abdel-Sattar E.   +7 more
europepmc   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Linking Metabolomic Diversity to Pharmacological Potency in Anonidium mannii Leaf Extracts. [PDF]

Chem Biodivers
Ojo O, More GK, Prinsloo G.
europepmc   +1 more source

Antitumor and antimetastatic activities of chloroform extract of medicinal mushroom Cordyceps taii in mouse models. [PDF]

BMC Complement Altern Med, 2015
Liu RM, Zhang XJ, Liang GY, Yang YF, Zhong JJ, Xiao JH.   +5 more
europepmc   +1 more source

Ein Apparat zur Extraction wässeriger Flüssigkeiten mit Chloroform [PDF]

Fresenius' Zeitschrift für analytische Chemie, 1901
openaire   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Bioactivity-Guided Fractionation, Characterization, and Mechanistic Insights of Anticancer Agents from <i>Simarouba glauca</i> DC. Leaves. [PDF]

Molecules
Rudraswamy S, G V YD, Sheshanna SH, Doggalli N, Madhunapantula SV.   +4 more
europepmc   +1 more source