Results 11 to 20 of about 458 (91)

Biodistribution and respiratory toxicity of chloromethylisothiazolinone/methylisothiazolinone following intranasal and intratracheal administration

Environment International, 2022
A variety of isothiazolinone-containing small molecules have been registered and used as chemical additives in many household products. However, their biodistribution and potential harmful effects on human health, especially respiratory effects, were not
Mi-Kyung Song, Jung Eun Park, Seung-Hun Ryu, Yong-Wook Baek, Young-Hee Kim, Dong Im Kim, Sung-Hoon Yoon, Hyunil Shin, Jongho Jeon, Kyuhong Lee   +9 more
doaj   +3 more sources

Effects of a mixture of chloromethylisothiazolinone and methylisothiazolinone on peripheral airway dysfunction in children. [PDF]

PLoS ONE, 2017
Children who were only exposed to a mixture of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) as humidifier disinfectant (HD) components were evaluated for humidifier disinfectant-associated lung injury (HDLI) from 2012.
Hyun-Ju Cho, Dong-Uk Park, Jisun Yoon, Eun Lee, Song-I Yang, Young-Ho Kim, So-Yeon Lee, Soo-Jong Hong   +7 more
doaj   +4 more sources

Characteristics of Exposure to Chloromethylisothiazolinone (CMIT) and Methylisothiazolinone (MIT) among Humidifier Disinfectant-Associated Lung Injury (HDLI) Patients in South Korea [PDF]

Molecules, 2020
This study aimed to quantify both chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) dissolved in different product brands and to characterize the exposure to these chemicals among humidifier disinfectant-associated lung injury (HDLI ...
Dong-Uk Park, Seon-Kyung Park, Jiwon Kim, Jihoon Park, Seung-Hun Ryu, Ju-Hyun Park, So-Yeon Lee, Han Bin Oh, Sungkyoon Kim, Kyung Ehi Zoh, Soyoung Park, Jung-Hwan Kwon   +11 more
doaj   +3 more sources

Strain and sex differences in chloromethylisothiazolinone and methylisothiazolinone-induced lung injury in mice

Ecotoxicology and Environmental Safety
Mouse strain and sex variability may provide a better understanding of the isothiazolinone-associated respiratory toxicity profile; however, this remains poorly understood.
Mi-Kyung Song, Jiwon Choi, Jiyoung Park, Dong Im Kim, Yong-Wook Baek, Kyuhong Lee   +5 more
doaj   +3 more sources

Review of Inhalation Health Risks Involving Chloromethylisothiazolinone (CMIT) and Methylisothiazolinone (MIT) Used as Disinfectants in Household Humidifiers. [PDF]

J Korean Med Sci, 2022
The association between lung injury and exposure to humidifier disinfectant (HD) containing a mixture of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) has been controversial in South Korea. This study conducts a literature review in order to evaluate the likelihood of CMIT/MIT reaching the lower part of the respiratory tract and ...
Kim J, Park S, Zoh KE, Park J, Choi S, Hwang SH, Lee SY, Park DU.   +7 more
europepmc   +3 more sources

New data on the metabolism of chloromethylisothiazolinone and methylisothiazolinone in human volunteers after oral dosage: excretion kinetics of a urinary mercapturic acid metabolite ("M-12"). [PDF]

Arch Toxicol, 2021
AbstractMethylisothiazolinone (MI) as well as the mixture of chloromethylisothiazolinone/methylisothiazolinone [MCI/MI (3:1)] are biocides that are used in a variety of products of every-day life. Due to the skin sensitizing properties of these biocides, their use has come under scrutiny.
Schettgen T, Bertram J, Kraus T.
europepmc   +6 more sources

Asthma‐inducing potential of 28 substances in spray cleaning products—Assessed by quantitative structure activity relationship (QSAR) testing and literature review

Journal of Applied Toxicology, Volume 42, Issue 1, Page 130-153, January 2022., 2022
Abstract Exposure to spray cleaning products constitutes a potential risk for asthma induction. We set out to review whether substances in such products are potential inducers of asthma. We identified 101 spray cleaning products for professional use. Twenty‐eight of their chemical substances were selected.
Niels Hadrup, Marie Frederiksen, Eva B. Wedebye, Nikolai G. Nikolov, Tanja K. Carøe, Jorid B. Sørli, Karen B. Frydendall, Biase Liguori, Camilla S. Sejbaek, Peder Wolkoff, Esben M. Flachs, Vivi Schlünssen, Harald W. Meyer, Per A. Clausen, Karin S. Hougaard   +14 more
wiley   +1 more source

Effects of chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) on Th2/Th17-related immune modulation in an atopic dermatitis mouse model [PDF]

Scientific Reports, 2020
AbstractExposure to chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) has been associated with allergic contact dermatitis and occupational asthma. Despite this association however, no study has investigated the effects of CMIT/MIT exposure on the development of atopic dermatitis (AD). This study was conducted to investigate the influence of
Go, Han-Na, Lee, Seung-Hwa, Cho, Hyun-Ju, Ahn, Jae-Rin, Kang, Mi-Jin, Lee, So-Yeon, Hong, Soo-Jong   +6 more
openaire   +2 more sources

Kathon Induces Fibrotic Inflammation in Lungs: The First Animal Study Revealing a Causal Relationship between Humidifier Disinfectant Exposure and Eosinophil and Th2-Mediated Fibrosis Induction

Molecules, 2020
Currently available toxicity data on humidifier disinfectants are primarily limited to polyhexamethylene guanidine phosphate-induced lung fibrosis.
Mi-Kyung Song, Dong Im Kim, Kyuhong Lee
doaj   +1 more source

Effects of Kathon, a Chemical Used Widely as a Microbicide, on the Survival of Two Species of Mosquitoes

Molecules, 2021
In recent decades, demands for novel insecticides against mosquitoes are soaring, yet candidate chemicals with desirable properties are limited. Kathon is a broad-spectrum isothiazolinone microbicide, but other applications remain uncharacterized. First,
Wen-Ze He, Li-Long Pan, Wen-Hao Han, Shaaban Abd-Rabou, Shu-Sheng Liu, Xiao-Wei Wang   +5 more
doaj   +1 more source