Results 111 to 120 of about 125,568 (336)

Artemisinin-naphthoquine combination versus chloroquine-primaquine to treat vivax malaria: an open-label randomized and non-inferiority trial in Yunnan Province, China [PDF]

, 2013
Hui Liu, Henglin Yang, Jian-Wei Xu, Jiazhi Wang, Ren-hua Nie, Chunfu Li   +5 more
openalex   +1 more source

Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology

Nature Reviews Rheumatology, 2020
E. Schrezenmeier, T. Dörner
semanticscholar   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Lack of Protection Against Ebola Virus from Chloroquine in Mice and Hamsters

Emerging Infectious Diseases, 2015
The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations.
Darryl Falzarano, David Safronetz, Joseph B. Prescott, Andrea Marzi, Friederike Feldmann, Heinz Feldmann   +5 more
doaj   +1 more source

A Case of Chloroquine-Induced Cardiomyopathy That Presented as Sick Sinus Syndrome [PDF]

, 2010
Jae Hak Lee, Woo‐Baek Chung, Ju Hyun Kang, Hyung Woo Kim, Jin Jin Kim, Ji Hyun Kim, Hui‐Jeong Hwang, Jea Beom Lee, Jong Won Chung, Hyo Lim Kim, Yun Seok Choi, Chul Soo Park, Ho‐Joong Youn, Man Young Lee   +13 more
openalex   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

International Journal of Antimicrobial Agents, 2020
C. Devaux, J. Rolain, P. Colson, D. Raoult   +3 more
semanticscholar   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19

Journal of critical care, 2020
A. Cortegiani, G. Ingoglia, M. Ippolito, A. Giarratano, S. Einav   +4 more
semanticscholar   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source