Results 111 to 120 of about 93,237 (289)

XPC Deficiency Activate Cisplatin‐Mediated Autophagy in Bladder Cancer by Limiting Novel PHRF1‐Mediated Ubiquitination of the p53 Protein

Advanced Science, EarlyView.
This study reveals that XPC regulates autophagy signaling beyond its noncanonical DNA repair role, uncovering the XPC‐p‐ATM‐KDM4A‐PHRF1 axis as a novel mechanism for autophagy modulation under DNA damage stress. It identifies PHRF1 as a novel p53 ubiquitin ligase.
Baixiong Zhao, Yaqin Huang, Jiazhong Shi, Xiaozhou Zhou, Johan Bourghardt Fagman, Liwei Wang, Sha Liu, Wuxing Wang, Yuting Liu, Zhiwen Chen, Jin Yang   +10 more
wiley   +1 more source

CHLOROQUINE AND HYDROXYCHLOROQUINE: A MAJOR BREAKTHROUGH FOR COVID-19

, 2020
Kritika Verma, Inder Kumar
openalex   +2 more sources

Fe‐S Protein FDX1 Triggers Tumor‐Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC

Advanced Science, EarlyView.
Restoration of the mitochondrial Fe–S protein FDX1 suppresses clear cell renal cell carcinoma by coupling ferroptosis with tumor‐intrinsic innate immune activation. FDX1 induces mitochondrial dysfunction and mtDNA/mt‐dsRNA release, activating cGAS–STING and RIG‐I/MDA5–MAVS signaling to elicit type I interferon responses, thereby promoting antigen ...
Xing Huang, Shaoqing Yu, Wenjie Wei, Wen Tao, Tianwei Cai, Lequan Wen, Jiali Ye, Chi Zhang, Huayi Feng, Senming Cao, Baojun Wang, Xin Ma, Yan Huang, Xu Zhang   +13 more
wiley   +1 more source

Return of Widespread Chloroquine-Sensitive Plasmodium falciparum to Malawi [PDF]

, 2014
Anne Frosch, Miriam K. Laufer, Don P. Mathanga, Shannon Takala‐Harrison, Jacek Skarbinski, Cassidy W. Claassen, Fraction K. Dzinjalamala, Christopher V. Plowe   +7 more
openalex   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

Administration of chloroquine and hydroxychloroquine through feeding tubes: that was then and this is now

, 2022
Mariana Martins Gonzaga do Nascimento, Cristiane de Paula Rezende   +1 more
openalex   +2 more sources

Mitochondria‐Targeted AIE Materials for Oxidative Stress‐Mediated Cancer Therapy and Beyond

Aggregate, EarlyView.
This review summarizes recent advances in mitochondria‐targeted AIE materials that enable controllable oxidative stress for cancer therapy and beyond. It highlights the potential of such exogenous oxidative stress in innovative therapeutic applications and biological regulation, while also outlining key limitations and future perspectives.
Na Hao, Bohong Chen, Xinxiang Wei, Yixuan Bao, Ru Zhang, Pu Chen, Jia Liu, Heqi Gao, Rongfu Tu, Chao Chen   +9 more
wiley   +1 more source

Pfcrt K76T and Pfmdr 1 Resistance Genes in Post Chloroquine Era in South-South Region of Nigeria

, 2019
Tolulope Alade, Ewaoche Sunday Itodo, Ebidor Lawani, Gloria Adie, Mirabeau Youtchou Tatfeng   +4 more
openalex   +2 more sources

Aggregation‐Induced Triplet Symmetry‐Breaking Charge Separation Drives Electron Transfer for Autophagy Blockade‐Enhanced Type‐I Photodynamic Therapy

Aggregate, EarlyView.
This study presents a novel class of cyanine‐based photosensitizers (PS) to achieve controllable switching between Type‐I and Type‐II mechanisms during photodynamic therapy. The formation of radical ion pairs (PS•+−PS•−) via symmetry‐breaking charge separation in aggregated systems at the triplet state, triggering Type‐I cascade reactions for effective
Xin Li, Fuping Han, Xiao Zhou, Hongyi Zhang, Tiancong Shi, Lihan Cai, Danhong Zhou, Weijie Chi, Saran Long, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng   +12 more
wiley   +1 more source

Pharmacology Progresses and Applications of Chloroquine in Cancer Therapy

International Journal of Nanomedicine
Yanqing Liu,1,* Yuqing Meng,1,* Junzhe Zhang,1 Liwei Gu,1 Shengnan Shen,1 Yongping Zhu,1 Jigang Wang1,2 1State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-Di Herbs, Artemisinin Research Center, and Institute of Chinese Materia
Liu Y, Meng Y, Zhang J, Gu L, Shen S, Zhu Y, Wang J   +6 more
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