Results 121 to 130 of about 85,533 (259)

Development and evaluation of glycine conjugated polypropyleneimine dendrimers for targeted chloroquine delivery. [PDF]

Discov Nano
Saraogi GK, Parashar AK, Yasin HKA, Ahirwar J, Kumari M.   +4 more
europepmc   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Use of chloroquine, hydroxychloroquine or ivermectin for Covid-19 prevention in vulnerable Brazilian populations. [PDF]

Rev Saude Publica
Castanheira D, Torres TS, Aranha TR, Soares F, Dourado I, Veloso VG.   +5 more
europepmc   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Reversal of Chloroquine Resistance in <i>Plasmodium falciparum</i> in Gabon: A Phenotype-Genotype Relationship over the Last 20 Years. [PDF]

Int J Mol Sci
Inoue J, Rodi M, Bohissou FET, de Carvalho LP, Lohse K, Koehne E, Agnandji ST, Mombo-Ngoma G, Kremsner PG, Kreidenweiss A, Held J.   +10 more
europepmc   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

APOE4-Expressing Astrocytes Exhibit Parkinson's Disease-Related Pathology. [PDF]

Mol Neurobiol
Lior N, Anna P, Roni H, Daniel MM, Dan F, Ronit PK.   +5 more
europepmc   +1 more source

RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B

The FEBS Journal, EarlyView.
The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal, Valérie C. Cabana, Antoine Y. Bouchard, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Autophagy inhibition potentiates the antileukemic effect of FLT3 inhibitors and overcomes resistance in FLT3-ITD acute myeloid leukemia. [PDF]

Cell Death Discov
Albuquerque de Melo M, Santos de Macedo BG, Pereira-Martins DA, Alves-Silva AB, Fonseca NP, de Miranda LBL, Silva CLA, Scheucher PS, Schuringa JJ, Machado-Neto JA, Traina F.   +10 more
europepmc   +1 more source

Captivating Synergistic, Dose-Dependent Anticancer Effects of Tumor-Regulation Modulators Chloroquine and Ivermectin Completely Abolished by an Opposing Modulator, Deoxycholic Acid, in Hamster Fibrosarcoma: In Vivo, In Vitro, and Literature Review. [PDF]

Pharmaceuticals (Basel)
Popović KJ, Popović DJ, Miljković D, Popović JK, Poša M, Drljača Lero J, Dolićanin Z.   +6 more
europepmc   +1 more source