Results 151 to 160 of about 93,237 (289)

Sodium butyrate ameliorates renal tubular lipid accumulation through a protein phosphatase 2A/transcription factor EB axis in diabetic nephropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Extensive evidence indicates that lipid accumulation causes renal tubular injury, which further contributes to diabetic nephropathy (DN) progression. Short‐chain fatty acids (SCFAs) play an important role in the maintenance of cellular metabolic health.
Jiayin Tao, Sinan Ai, Yaoxian Wang, Yuning Liu, Jingwei Zhou, Qingqing Liu, Xu Wang, Danting Li, Xin Li, Lin Wang, Jinyi Hou, Liang Peng, Zhen Wang   +12 more
wiley   +1 more source

Combating COVID-19 with Chloroquine [PDF]

, 2020
Wanjin Hong
openalex   +1 more source

Eschweilenol C and subfractions from Terminalia plants disrupt haemoglobin metabolism, inhibiting Plasmodium falciparum growth at rings and trophozoite stages. [PDF]

Malar J
Tali MBT, Mbouna CDJ, Zehra A, Wouamba SCN, Mouthe GPK, Kamche AY, Dize D, Kouam SF, Kamdem BP, Tchouankeu JC, Khan F, Boyom FF.   +11 more
europepmc   +1 more source

Quantitative fundus autofluorescence (QAF) in chloroquine/hydroxychloroquine (CQ/HCQ) patients: one-year follow-up.

, 2020
Victoria Radun, Andreas Berlin, Clara Reichel, Nikolai Kleefeldt, Ioana‐Sandra Tarau, Jost Hillenkamp, Kenneth R. Sloan, Thomas Ach   +7 more
openalex   +1 more source

SNAPIN Facilitates Progression of Hepatocellular Carcinoma by Hindering Ferroptosis Through KEAP1 Degradation Promotion

Cancer Science, EarlyView.
Our findings have revealed that the intracellular SNAPIN interplays with KEAP1 to promote KEAP1 protein degradation via the autophagy‐lysosomal pathway. Accordingly, NRF2 dissociates from KEAP1 for nuclear translocation, thus activating its target gene GPX4.
Xuan Liu, Weiling Xu, Zhen Li, Rongqing Li, Jin Chen, Jianhua Wang   +5 more
wiley   +1 more source

Rapamycin and Chloroquine Modulate Insulin Resistance and Hepatic Steatosis in a High-Fat/High-Cholesterol Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Mouse Model. [PDF]

Diabetes Metab Syndr Obes
Liu Q, Du Q, Yuan X, Zhang T, Li J, Xu J, Xie R.   +6 more
europepmc   +1 more source

Mutant p53 Regulates Pyruvate Dehydrogenase Kinase 1 (PDK1) to Promote Proliferation and Migration in Breast Cancer

Cancer Science, EarlyView.
PDK1 is a direct transcriptional repression target of wtp53 and mutp53 can sustain its own stability by upregulating PDK1 in breast cancer. ABSTRACT Tumor suppressor p53 is the most frequently mutated gene in cancers. Mutations in p53 not only result in the loss of its classical tumor‐suppressive functions but also confer new oncogenic properties.
Yan Ye, Zuli Ou, Canling Li, Qingyu Liao, Qian Zeng, Xiaoqian Ju, Dian Zhang, Yu Wei, Xiang Zhang, Tao Zhang, Kejia Wu   +10 more
wiley   +1 more source

Assessing ADME gene coverage: An observational study on chloroquine therapy for COVID-19. [PDF]

Medicine (Baltimore)
Zaid N, Benchikhi L, El Abboudi N, Khalki L, Badad O, Limami Y, Naya A, Oudghiri M, Himmi B, Zaid Y.   +9 more
europepmc   +1 more source

Chloroquine mitigates long-term effects of in vitro culture in mouse embryos

Kaname Sato, Itsuki Koide, Md. Wasim Bari, Satoshi Kishigami   +3 more
openalex   +1 more source

A review on possible modes of action of chloroquine/hydroxychloroquine: repurposing against SAR-CoV-2 (COVID-19) pandemic

, 2020
Satyajit Tripathy, Barsha Dassarma, Somenath Roy, Hlupheka Chabalala, Motlalepula G. Matsabisa   +4 more
openalex   +2 more sources