Results 11 to 20 of about 93,237 (289)
Cells, 2023 Lysosomotropic agent chloroquine was shown to sensitize non-stem glioblastoma cells to radiation in vitro with p53-dependent apoptosis implicated as one of the underlying mechanisms. The in vivo outcomes of chloroquine or its effects on glioblastoma stem
Andreas Müller +11 more
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Neurological and psychiatric safety of tafenoquine in Plasmodium vivax relapse prevention: a review
Malaria Journal, 2020 Background Tafenoquine is an 8-aminoquinoline anti-malarial drug recently approved as a single-dose (300 mg) therapy for Plasmodium vivax relapse prevention, when co-administered with 3-days of chloroquine or other blood schizonticide. Tafenoquine 200 mg
Stephan Duparc +4 more
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A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria. [PDF]
PLoS ONE, 2012 The predominance of chloroquine-susceptible falciparum malaria in Malawi more than a decade after chloroquine's withdrawal permits contemplation of re-introducing chloroquine for targeted uses.
Miriam K Laufer +8 more
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Chloroquine is a zinc ionophore. [PDF]
PLoS ONE, 2014 Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation ...
Jing Xue +5 more
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Journal of Ophthalmology, 2021 The article is on an important subject, chloroquine maculopathy associated with long-term use of chloroquine. Given that chloroquine has been widely used for the treatment of COVID-19, it is important to accumulate data on adverse reaction to chloroquine
N. V. Malachkova, T. Ie. Kozlova
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Malaria Journal, 2011 Background As a result of widespread chloroquine and sulphadoxine-pyrimethamine (SP) resistance, 90% of sub-Saharan African countries had adopted policies of artemisinin-based combination therapy (ACT) for treatment of uncomplicated malaria by 2007.
Venkatesan Meera +2 more
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Near Infrared Fluorophore-Tagged Chloroquine in Plasmodium falciparum Diagnostic Imaging
Molecules, 2018 Chloroquine was among the first of several effective drug treatments against malaria until the onset of chloroquine resistance. In light of diminished clinical efficacy of chloroquine as an antimalarial therapeutic, there is potential in efforts to adapt
Li Yan Chan +5 more
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The Level of Effectiveness Use of Quinoline Drugs in COVID-19: A Literature Review
Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, 2020 Chloroquine is the first line of medicine in the treatment of malaria. Besides being antimalaria, the chloroquine also can be used as the anti-inflammation in the medicine of arthritis rheumatoid arthritis and lupus erythematosus discoid ...
M.Dedi Dermawan Dermawan +3 more
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Does mass chloroquine treatment have any role in the elimination of Plasmodium vivax ? [PDF]
Malar JWhite NJ, Mehra S, Watson JA.
europepmc +3 more sources
Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies
BMC Bioinformatics, 2019 Background Malaria is a major global health problem, with the Plasmodium falciparum protozoan parasite causing the most severe form of the disease. Prevalence of drug-resistant P. falciparum highlights the need to understand the biology of resistance and
Ana M. Untaroiu +3 more
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