Results 11 to 20 of about 125,568 (336)
Chloroquine is a zinc ionophore. [PDF]
PLoS ONE, 2014 Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation ...
Jing Xue +5 more
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Nature Communications, 2021 Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate the effects of hydroxychloroquine
C. Axfors +93 more
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JAMA Network Open, 2020 Key Points Question How safe and effective are 2 different regimens of chloroquine diphosphate in the treatment of severe coronavirus disease 2019 (COVID-19)? Findings In this phase IIb randomized clinical trial of 81 patients with COVID-19, an unplanned
M. Borba +27 more
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Malaria Journal, 2011 Background As a result of widespread chloroquine and sulphadoxine-pyrimethamine (SP) resistance, 90% of sub-Saharan African countries had adopted policies of artemisinin-based combination therapy (ACT) for treatment of uncomplicated malaria by 2007.
Venkatesan Meera +2 more
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The Level of Effectiveness Use of Quinoline Drugs in COVID-19: A Literature Review
Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, 2020 Chloroquine is the first line of medicine in the treatment of malaria. Besides being antimalaria, the chloroquine also can be used as the anti-inflammation in the medicine of arthritis rheumatoid arthritis and lupus erythematosus discoid ...
M.Dedi Dermawan Dermawan +3 more
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Near Infrared Fluorophore-Tagged Chloroquine in Plasmodium falciparum Diagnostic Imaging
Molecules, 2018 Chloroquine was among the first of several effective drug treatments against malaria until the onset of chloroquine resistance. In light of diminished clinical efficacy of chloroquine as an antimalarial therapeutic, there is potential in efforts to adapt
Li Yan Chan +5 more
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Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies
BMC Bioinformatics, 2019 Background Malaria is a major global health problem, with the Plasmodium falciparum protozoan parasite causing the most severe form of the disease. Prevalence of drug-resistant P. falciparum highlights the need to understand the biology of resistance and
Ana M. Untaroiu +3 more
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Lack of Evidence for Chloroquine-Resistant Plasmodium falciparum Malaria, Leogane, Haiti
Emerging Infectious Diseases, 2012 Plasmodium falciparum malaria in Haiti is considered chloroquine susceptible, although resistance transporter alleles associated with chloroquine resistance were recently detected.
Ami Neuberger +3 more
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Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
Autophagy, 2018 Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation.
Mario Mauthe +9 more
semanticscholar +1 more source
Chloroquine and hydroxychloroquine in covid-19
British medical journal, 2020 Use of these drugs is premature and potentially ...
R. Ferner, J. Aronson
semanticscholar +1 more source