Results 221 to 230 of about 93,237 (289)
Quinoline derivatives' biological interest for anti-malarial and anti-cancer activities: an overview. [PDF]
RSC AdvChavan ND, Sarveswari S, Vijayakumar V.
europepmc +1 more source
Food Science &Nutrition, Volume 13, Issue 12, December 2025.Transcriptomic profiling showed that carotenoid‐rich lipophilic sea buckthorn extract (LSBE) significantly altered genes controlling cholesterol metabolism, mTORC1 signaling, oxidative stress, and ferroptosis in BT‐549 TNBC cells. These findings generate mechanistic hypotheses for LSBE as a potential complementary approach in TNBC therapy, pending ...
Simona Visan +4 more
wiley +1 more source
Eyelid nodule with persistent growth. [PDF]
JAAD Case RepHoellwerth M +4 more
europepmc +1 more source
The Role of ACE2 in SARS‐CoV‐2 Infection, Pathogenesis, and Antiviral Interventions
Journal of Medical Virology, Volume 97, Issue 12, December 2025.ABSTRACT The devastating clinical, psychological, and economic impact of the COVID‐19 pandemic, caused by global spread of the second Severe Acute Respiratory Syndrome Coronavirus (SARS‐CoV‐2), has engendered a massive response from the scientific community to rapidly understand the biology of SARS‐CoV‐2 and to develop interventions to prevent ...
Michael A. McVoy +1 more
wiley +1 more source
GLMP promotes EGFR-TKI resistance by activating autophagy and RhoA pathway in non-small cell lung cancer. [PDF]
NPJ Precis OncolLiang X +13 more
europepmc +1 more source
Discovery of a Novel Non‐Nucleoside Inhibitor of RNA‐Dependent RNA Polymerase Against Dengue Virus
MedComm, Volume 6, Issue 12, December 2025.PN‐1, a novel non‐nucleoside inhibitor of the dengue virus RNA‐dependent RNA polymerase (RdRp), was identified from Panax notoginseng. This compound selectively targets the DENV‐2 NS5 RdRp, inducing conformational changes that inhibit enzymatic activity, thereby suppressing DENV replication both in vitro and in vivo.
Xue‐Mei He +11 more
wiley +1 more source
Autophagy in PE: Dispute, Role and Potential Target
Cell Proliferation, Volume 58, Issue 12, December 2025.Autophagy homeostasis serves as a central hub regulating vascular remodelling during pregnancy. It integrates maternal, genetic, and fetal factors; shapes the functions of immune cells (NK cells, macrophages, and T cells); restrains endothelial inflammatory responses (cytokines, endothelial cell, oxidative/ER stress, and protein aggregation); and ...
Miao Xu +12 more
wiley +1 more source
Chloroquine inhibits salinomycin-induced autophagy for collaborative anticancer effect in breast cancer. [PDF]
BioimpactsYang X, Jin Z, Chen G, Hu G.
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International Journal of Immunogenetics, Volume 52, Issue 6, Page 371-378, December 2025.ABSTRACT Toll‐like receptors (TLRs) induce the production of pro‐inflammatory cytokines and regulate the immune response to Plasmodium vivax infection. Genetic variants of TLRs are associated with susceptibility and severity of malaria in different populations. This study aimed to evaluate the association between polymorphisms in TLR1, TLR4, TLR7, TLR8,
Mikaele Monik Rodrigues Inácio Silva +8 more
wiley +1 more source