Results 221 to 230 of about 107,140 (318)

High‐throughput screening identifies bazedoxifene as a potential therapeutic for dysferlin‐deficient limb girdle muscular dystrophy

British Journal of Pharmacology, Volume 182, Issue 13, Page 2930-2949, July 2025.
Abstract Background and Purpose Limb‐girdle muscular dystrophy R2 (LGMD R2) is a rare genetic disorder characterised by progressive weakness and wasting of proximal muscles. LGMD R2 is caused by the loss of function of dysferlin, a transmembrane protein crucial for plasma membrane repair in skeletal muscles.
Celine Bruge, Nathalie Bourg, Emilie Pellier, Johana Tournois, Jerome Polentes, Manon Benabides, Noella Grossi, Anne Bigot, Anthony Brureau, Isabelle Richard, Xavier Nissan   +10 more
wiley   +1 more source

Metformin and chloroquine enhanced the efficacy of cytarabine in acute lymphoblastic leukemia cell lines: a drug repositioning approach. [PDF]

Sci Rep
Poodeh AM, Sarab GA, Ravari MP, Najafzadeh M, Safarpour H, Zarban A, Sayadi M, Sajjadi SM.   +7 more
europepmc   +1 more source

TOXICOLOGICAL STUDIES ON THE CHLOROQUINE-MELANIN AFFINITY IN VIVO AND IN VITRO IN RELATION TO THE CHLOROQUINE RETINOPATHY

, 1976
Yutaka Kasuya, Hiroshi Miyata, Minoru Watanabe   +2 more
openalex   +2 more sources

Evidence on the Use of Topical Ciclosporin for Ocular Surface Disease: A Systematic Review and Meta‐Analysis

Clinical &Experimental Ophthalmology, Volume 53, Issue 5, Page 470-492, July 2025.
ABSTRACT Background To identify evidence on the use of topical CsA for ocular surface diseases (OSD). Methods A literature search was conducted following the preferred reporting items for systematic reviews and meta‐analyses (PRISMA) through June 2023 via Cochrane Central Registries, Clinical Trials Registry, Grey literature and citation searching ...
Ngozi C. Chidi‐Egboka, Leo Fan, Maria Qureshi, Chameen Samarawickrama, Fiona Stapleton, Tanya Trinh, Maria Markoulli, Elsie Chan, Jern Yee Chen, Jason Holland, Stephanie L. Watson   +10 more
wiley   +1 more source

Decreased Responsiveness to Chemical Itch in Old Mice. [PDF]

Cells
Zhao Q, Tominaga M, Toyama S, Honda K, Komiya E, Kamata Y, Ma H, Takamori K.   +7 more
europepmc   +1 more source

Protein binding of chloroquine enantiomers and desethylchloroquine. [PDF]

, 1986
David Ofori‐Adjei, Örjan Ericsson, Björn Lindström, Folke Sjöqvist   +3 more
openalex   +1 more source

CircMAN1A2 Levels Determine GBM Susceptibility to TMZ in a Pathway Involving TEP1‐ and KEAP1‐Mediated NRF2 Degradation Leading to Ferroptosis

CNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.
PRPF40B promotes circMAN1A2 expression, inhibiting TEP1‐KEAP1 complex formation, leading to NRF2 degradation and ferroptosis in GSCs. Without circMAN1A2, NRF2 activation inhibits ferroptosis and promotes TAMs' M2 polarization. ABSTRACT Background Glioblastoma (GBM) is a highly aggressive brain tumor with poor prognosis and resistance to temozolomide ...
Xinqiao Li, Jinpeng Hu, Wei Zheng, Zongming Fan, Hao Chi, Hao Li, Yongfeng Wang, Zhitao Jing   +7 more
wiley   +1 more source

Chloroquine Causes Aging-like Changes in Diaphragm Neuromuscular Junction Morphology in Mice. [PDF]

Cells
Gulbronson CI, Jahanian S, Gransee HM, Sieck GC, Mantilla CB.   +4 more
europepmc   +1 more source

Delayed-onset chloroquine retinopathy. [PDF]

, 1986
Michael Ehrenfeld, Ронит Нешер, S. Merin   +2 more
openalex   +1 more source

GANT61 Modulates Autophagy and Lipid Metabolism in Ovarian Cancer

Cell Proliferation, Volume 58, Issue 7, July 2025.
GANT61 induced autophagy via the AKT pathway and promoted the accumulation of lipid droplets in both cell lines. The molecular mechanism behind this lipid accumulation appears to involve the mediation of SREBP1. Furthermore, the combination of GANT61 with CQ/Fatostatin significantly inhibited the proliferation and clonogenicity of SKOV3 and SKOV3PTX ...
Yibin Pan, Lingfeng Chen, Jinlu Shen, Shihao Hong, Xiaojing Guan, Xudong Ma, Rongrong Tang, Meifei Lu, Fangying Sun, Shanliang Shang, Yongdong Dai, Zhaokai Zhou, Songying Zhang, Jianhua Yang   +13 more
wiley   +1 more source