Results 21 to 30 of about 107,140 (318)

Chloroquine increases phosphorylation of AMPK and Akt in myotubes

Heliyon, 2016
Aims: There are reports that ataxia telangiectasia mutated (ATM) can activate the AMP-activated protein kinase (AMPK) and also Akt, two kinases that play integral parts in cardioprotection and metabolic function.
Larry D. Spears, Andrew V. Tran, Charles Y. Qin, Supriya B. Hobbs, Cheryl A. Liang Burns, Nathaniel K. Royer, Zhihong Zhang, Lyle Ralston, Jonathan S. Fisher   +8 more
doaj   +1 more source

Chloroquine and hydroxychloroquine in covid-19

British medical journal, 2020
Use of these drugs is premature and potentially ...
R. Ferner, J. Aronson
semanticscholar   +1 more source

Effect of Chloroquine, Hydroxychloroquine, and Azithromycin on the Corrected QT Interval in Patients With SARS-CoV-2 Infection

Circulation: Arrhythmia and Electrophysiology, 2020
Background: The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is responsible for the global coronavirus disease 2019 pandemic.
Moussa Saleh, James K. Gabriels, David Chang, Beom Soo Kim, Amtul Mansoor, Eitezaz Mahmood, P. Makker, Haisam Ismail, B. Goldner, J. Willner, S. Beldner, R. Mitra, R. John, J. Chinitz, Nicholas Skipitaris, Stavros E. Mountantonakis, L. Epstein   +16 more
semanticscholar   +1 more source

Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda

Malaria Journal, 2020
Background Usage of chloroquine was discontinued from the treatment of Plasmodium falciparum infection in almost all endemic regions because of global spread of resistant parasites.
Betty Balikagala, Miki Sakurai-Yatsushiro, Shin-Ichiro Tachibana, Mie Ikeda, Masato Yamauchi, Osbert T. Katuro, Edward H. Ntege, Makoto Sekihara, Naoyuki Fukuda, Nobuyuki Takahashi, Shouki Yatsushiro, Toshiyuki Mori, Makoto Hirai, Walter Opio, Paul S. Obwoya, Denis A. Anywar, Mary A. Auma, Nirianne M. Q. Palacpac, Takafumi Tsuboi, Emmanuel I. Odongo-Aginya, Eisaku Kimura, Martin Ogwang, Toshihiro Horii, Toshihiro Mita   +23 more
doaj   +1 more source

Insights from nanomedicine into chloroquine efficacy against COVID-19

Nature Nanotechnology, 2020
Chloroquine — an approved malaria drug — is known in nanomedicine research for the investigation of nanoparticle uptake in cells, and may have potential for the treatment of COVID-19.
Tony Y. Hu, M. Frieman, Joy Wolfram
semanticscholar   +1 more source

Plasmodium vivax trophozoites insensitive to chloroquine

Malaria Journal, 2008
Background Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp.
Jaidee Anchalee, Travers Thomas, Kosaisavee Varakorn, Edstein Michael D, Lek-Uthai Usa, Suwanarusk Rossarin, Sharrock Wesley W, Sriprawat Kanlaya, Price Ric N, Nosten François, Russell Bruce   +10 more
doaj   +1 more source

Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay. [PDF]

PLoS ONE, 2014
Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole.
Cheryl C Y Loh, Rossarin Suwanarusk, Yan Quan Lee, Kitti W K Chan, Kit-Ying Choy, Laurent Rénia, Bruce Russell, Martin J Lear, François H Nosten, Kevin S W Tan, Larry M C Chow   +10 more
doaj   +1 more source

Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know

Annals of Internal Medicine, 2020
Two medications often used for treatment of immune-mediated conditions, hydroxychloroquine and chloroquine, have recently attracted widespread interest as potential therapies for coronavirus disease 2019.
J. Yazdany, A. H. Kim
semanticscholar   +1 more source

Chloroquine resistant Plasmodium vivax: in vitro characterisation and association with molecular polymorphisms. [PDF]

PLoS ONE, 2007
Treatment failure of chloroquine for P. vivax infections has reached high levels in the eastern provinces of Indonesia, however, in vitro characterization of chloroquine resistance and its associated molecular profile have yet to be determined.Using a ...
Rossarin Suwanarusk, Bruce Russell, Marina Chavchich, Ferryanto Chalfein, Enny Kenangalem, Varakorn Kosaisavee, Budi Prasetyorini, Kim A Piera, Marion Barends, Alan Brockman, Usa Lek-Uthai, Nicholas M Anstey, Emiliana Tjitra, François Nosten, Qin Cheng, Ric N Price   +15 more
doaj   +1 more source

Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19

Cochrane Database of Systematic Reviews, 2020
Background The coronavirus disease 2019 (COVID‐19) pandemic has resulted in substantial mortality. Some specialists proposed chloroquine (CQ) and hydroxychloroquine (HCQ) for treating or preventing the disease. The efficacy and safety of these drugs have
Bhagteshwar Singh, H. Ryan, T. Kredo, Marty Chaplin, T. Fletcher   +4 more
semanticscholar   +1 more source