Results 21 to 30 of about 177,805 (383)

Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections [PDF]

, 2013
Background: Plasmodium knowlesi is a cause of symptomatic and potentially fatal infections in humans. There are no studies assessing the detailed parasitological response to treatment of knowlesi malaria infections in man and whether antimalarial ...
Cox Singh, Janet, Daneshvar, Cyrus, Davis, Timothy M. E., Divis, Paul C. S., Rafa'ee, Mohammad Z., Singh, Balbir, Zakaria, Siti K.   +6 more
core   +1 more source

Lack of Evidence for Chloroquine-Resistant Plasmodium falciparum Malaria, Leogane, Haiti

Emerging Infectious Diseases, 2012
Plasmodium falciparum malaria in Haiti is considered chloroquine susceptible, although resistance transporter alleles associated with chloroquine resistance were recently detected.
Ami Neuberger, Kathleen Zhong, Kevin C Kain, Eli Schwartz   +3 more
doaj   +1 more source

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

Autophagy, 2018
Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation.
Mario Mauthe, I. Orhon, C. Rocchi, Xingdong Zhou, Morten Luhr, Kerst-Jan Hijlkema, R. Coppes, N. Engedal, M. Mari, F. Reggiori   +9 more
semanticscholar   +1 more source

Chloroquine and hydroxychloroquine in covid-19

British medical journal, 2020
Use of these drugs is premature and potentially ...
R. Ferner, J. Aronson
semanticscholar   +1 more source

Autophagy processes are dependent on EGF receptor signaling [PDF]

, 2018
Autophagy is a not well-understood conserved mechanism activated during nutritional deprivation in order to maintain cellular homeostasis. In the present study, we investigated the correlations between autophagy, apoptosis and the MAPK pathways in ...
Capodifoglio, Sabrina, Caruso, Marika, Conti, Pio, Flati, Vincenzo, Iuliis, Vincenzo De, Lanuti, Paola, Marino, Antonio, Marricareda, Valeria, Martinotti, Stefano, Marynuk, Anna, Talora, Claudio, Toniato, Elena, Ursi, Sebastiano   +12 more
core   +1 more source

Effect of Chloroquine, Hydroxychloroquine, and Azithromycin on the Corrected QT Interval in Patients With SARS-CoV-2 Infection

Circulation: Arrhythmia and Electrophysiology, 2020
Background: The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is responsible for the global coronavirus disease 2019 pandemic.
Moussa Saleh, James K. Gabriels, David Chang, Beom Soo Kim, Amtul Mansoor, Eitezaz Mahmood, P. Makker, Haisam Ismail, B. Goldner, J. Willner, S. Beldner, R. Mitra, R. John, J. Chinitz, Nicholas Skipitaris, Stavros E. Mountantonakis, L. Epstein   +16 more
semanticscholar   +1 more source

Absent in vitro interaction between chloroquine and antifungals against Aspergillus fumigatus [PDF]

, 2017
This work was supported by Medical Mycology Section, Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Seyedmousavi, Seyedmojtaba, van der Lee, Henrich, Verweij, Paul, Warris, Adilia   +3 more
core   +1 more source

Chloroquine increases phosphorylation of AMPK and Akt in myotubes

Heliyon, 2016
Aims: There are reports that ataxia telangiectasia mutated (ATM) can activate the AMP-activated protein kinase (AMPK) and also Akt, two kinases that play integral parts in cardioprotection and metabolic function.
Larry D. Spears, Andrew V. Tran, Charles Y. Qin, Supriya B. Hobbs, Cheryl A. Liang Burns, Nathaniel K. Royer, Zhihong Zhang, Lyle Ralston, Jonathan S. Fisher   +8 more
doaj   +1 more source

Insights from nanomedicine into chloroquine efficacy against COVID-19

Nature Nanotechnology, 2020
Chloroquine — an approved malaria drug — is known in nanomedicine research for the investigation of nanoparticle uptake in cells, and may have potential for the treatment of COVID-19.
Tony Y. Hu, M. Frieman, Joy Wolfram
semanticscholar   +1 more source

Plasmodium vivax trophozoites insensitive to chloroquine

Malaria Journal, 2008
Background Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp.
Jaidee Anchalee, Travers Thomas, Kosaisavee Varakorn, Edstein Michael D, Lek-Uthai Usa, Suwanarusk Rossarin, Sharrock Wesley W, Sriprawat Kanlaya, Price Ric N, Nosten François, Russell Bruce   +10 more
doaj   +1 more source