Results 61 to 70 of about 177,805 (383)

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

Nature Communications, 2018
Resetting tumor-associated macrophages (TAMs) is a promising strategy to ameliorate the immunosuppressive tumor microenvironment and improve innate and adaptive antitumor immunity.
Degao Chen, Jing Xie, R. Fiskesund, Wenqian Dong, Xiaoyu Liang, Jiadi Lv, Xun Jin, Jinyan Liu, Siqi Mo, Tianzhen Zhang, Feiran Cheng, Yabo Zhou, Huafeng Zhang, K. Tang, Jingwei Ma, Yuying Liu, Bo Huang   +16 more
semanticscholar   +1 more source

Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19

medRxiv, 2020
Background Effective therapies are urgently needed for the SARS-CoV-2 pandemic. Chloroquine has been proved to have antiviral effect against coronavirus in vitro.
Mingxing Huang, Man Li, Fei Xiao, P. Pang, Jiabi Liang, T. Tang, Shaoxuan Liu, Binghui Chen, Jingxian Shu, Yingying You, Yang Li, Meiwen Tang, Jianhui Zhou, Guanmin Jiang, J. Xiang, Wen-xin Hong, Songmei He, Zhaoqin Wang, Jianhua Feng, Changqing Lin, Y. Ye, Zhi-long Wu, Yaocai Li, Bei Zhong, Ruilin Sun, Z. Hong, Jing Liu, Huili Chen, Xiaohua Wang, Zhonghe Li, D. Pei, Lin Tian, J. Xia, Shanping Jiang, Nanshan Zhong, H. Shan   +35 more
semanticscholar   +1 more source

Brief Summary of Potential SARS-CoV-2 Prophylactic and Treatment Drugs in the Emergency Department [PDF]

, 2020
As of March 30th, 2020 there were 161,807 total cases and 2,953 total deaths of SARS-CoV-2 in the United States, with the number of cases expected to rise.
Brown, Cortlyn, Coralic, Zlatan, Noble, Jeanne   +2 more
core  

Genetic and genomic approaches for the discovery of parasite genes involved in antimalarial drug resistance [PDF]

, 2013
The biggest threat to the war on malaria is the continued evolution of drug resistance by the parasite. Resistance to almost all currently available antimalarials now exists in Plasmodium falciparum which causes the most suffering among all human malaria
Mwangi, J.M., Ranford-Cartwright, L.C.
core   +1 more source

Chloroquine Inhibits Ca2+ Signaling in Murine CD4+ Thymocytes

Cellular Physiology and Biochemistry, 2015
Background/Aims: Bitter-tasting chloroquine can suppress T cell activation by inhibiting Ca2+ signaling. However, the mechanism of inhibition remains largely unclear.
Jin-Chao Xu, Yong-Bo Peng, Ming-Yu Wei, Yi-Fan Wu, Donglin Guo, Gangjian Qin, Guangju Ji, Jinhua Shen, Qing-Hua Liu   +8 more
doaj   +1 more source

Chloroquine Attenuates Oxidative Stress in Gentamicin-Induced Nephrotoxicity in Rats

Dose-Response, 2022
The wider application of gentamicin is limited by potential adverse effects (nephrotoxicity and ototoxicity). The goal of our study was to investigate the effects of chloroquine on biochemical and oxidative stress parameters in gentamicin-induced ...
Branislava Medić Brkić, Branislav Rovčanin, Marko Stojanović, Dragana Srebro, Sonja Vučković, Katarina Savić Vujović   +5 more
doaj   +1 more source

A systematic review of the prophylactic role of chloroquine and hydroxychloroquine in coronavirus disease‐19 (COVID‐19)

International Journal of Rheumatic Diseases, 2020
The pandemic coronavirus disease‐19 (COVID‐19) has pushed the global healthcare system to a crisis and amounted to a huge economic burden. Different drugs for prophylaxis against COVID‐19 including chloroquine (CQ) or hydroxychloroquine (HCQ) have been ...
Sanket Shah, S. Das, Avinash Jain, D. Misra, V. Negi   +4 more
semanticscholar   +1 more source

Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]

, 1994
The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G., Birnstiel, Max L., Clausen, Henrik, Cotten, Matt, Dinter, André, Mechtler, Karl, Rusconi, Sandro, Thurnher, Martin, Wagner, Ernst   +8 more
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues

International Journal for Parasitology: Drugs and Drug Resistance, 2022
Malaria is among the tropical diseases that cause the most deaths in Africa. Around 500,000 malaria deaths are reported yearly among African children under the age of five. Chloroquine (CQ) is a low-cost antimalarial used worldwide for the treatment of Plasmodium vivax malaria.
Wilian A. Cortopassi, Emma Gunderson, Yasmin Annunciato, Antony.E.S. Silva, Amália dos Santos Ferreira, Carolina Bioni Garcia Teles, Andre S. Pimentel, Roopa Ramamoorthi, Marcos L Gazarini, Mario R. Meneghetti, Rafael.V.C. Guido, Dhelio B. Pereira, Matthew P. Jacobson, Antoniana U. Krettli, Anna Caroline C Aguiar   +14 more
openaire   +5 more sources