Results 61 to 70 of about 107,140 (318)

Toxicity of chloroquine and hydroxychloroquine following therapeutic use or overdose

Clinical toxicology, 2020
Introduction While chloroquine, a derivative of quinine, has been used as an antimalarial for 70 years, hydroxychloroquine is now used to treat conditions such as rheumatoid arthritis and systemic lupus erythematosus.
Cassandra R Doyno, D. Sobieraj, W. Baker
semanticscholar   +1 more source

A CMTM6 Nanobody Overcomes EGFR‐TKI Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Overcoming EGFR‐TKI resistance remains a critical challenge in NSCLC treatment. This study identifies CMTM6 as a key regulator of EGFR stability and demonstrates that a novel anti‐CMTM6 nanobody disrupts the CMTM6‐EGFR interaction. Targeting CMTM6 restores EGFR degradation, suppresses tumor growth, and confers therapeutic benefit in both CDX and PDX ...
Lu Xia, Jichuan Wang, Hui Xue, Haimeng Li, Qinghua Li, Sen Qin, Chunyu Yu, Yanhua Liu, Yu Gao, Lingyun Li, Sudun Guan, Enrun Zheng, Feiya Suo, Lin He, Yongsheng Wang, Wenling Han, Yongfeng Shang, Yong Geng, Luyang Sun   +18 more
wiley   +1 more source

Molecular surveillance of chloroquine-resistant Plasmodium falciparum in sub-Saharan African countries after withdrawal of chloroquine for treatment of uncomplicated malaria: A systematic review

Journal of Infection and Public Health, 2022
Background: A wide spread of chloroquine resistance prompted its discontinued use for treatment of uncomplicated malaria in several African countries. However, disappearances of chloroquine-resistant parasites have been reported in areas with restricted ...
Belinda J. Njiro, Ritah F. Mutagonda, Amisa T. Chamani, Tosi Mwakyandile, Deodatus Sabas, George M. Bwire   +5 more
doaj  

Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells. [PDF]

PLoS Pathogens, 2017
Trials to reintroduce chloroquine into regions of Africa where P. falciparum has regained susceptibility to chloroquine are underway. However, there are long-standing concerns about whether chloroquine increases lytic-replication of Epstein-Barr virus ...
Xiaofan Li, Eric M Burton, Sumita Bhaduri-McIntosh   +2 more
doaj   +1 more source

Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

Advanced Science, EarlyView.
In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu, Guoqing Jing, Shujuan Wu, Min Yuan, Yingyue Dong, Xue Chen, Huimin Zhou, Hailong Gong, Jing Zuo, Xiaojing Wu, Xuemin Song   +10 more
wiley   +1 more source

Beyond Anti-viral Effects of Chloroquine/Hydroxychloroquine

Frontiers in Immunology, 2020
As the world is severely affected by COVID-19 pandemic, the use of chloroquine and hydroxychloroquine in prevention or for the treatment of patients is allowed in multiple countries but remained at the center of much controversy in recent days.
V. Gies, N. Bekaddour, Y. Dieudonné, A. Guffroy, Quentin Frenger, F. Gros, M. Rodero, J. Herbeuval, A. Korganow   +8 more
semanticscholar   +1 more source

BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING

Advanced Science, EarlyView.
Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao, Siming Chen, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao, Hongbing Cai   +6 more
wiley   +1 more source

Use of chloroquine in uncomplicated falciparum malaria chemotherapy : The past, the present and the future

Sahel Medical Journal, 2010
Chloroquine is a 4-aminoquinoline discovered over five decades ago for treatment of uncomplicated malaria. It was widely used as first line treatment and prophylaxis for individuals going into malaria endemic regions.
Balogun S T, Sani M D, Fehintola F A, Sandabe   +3 more
doaj  

Evaluation of Effectiveness of Ethanolic Extract of Curcuma longa, discretely and in Combination with Chloroquine against Chloroquine-Sensitive Strain of Plasmodium berghei

Herbal Medicines Journal, 2019
Background and Aim: Malaria is a parasitic disease and one of the most important public health problem. Chemical medications such as chloroquine, primaquine, pyrimethamine, mefloquine, artemisinin and fansidar are commonly used to treat malaria but most ...
Peyman Heydarian, Mehdi Nateghpour *, Nahideh Mazhari, Afsaneh Motevalli Haghi, Leila Farivar, Effat Souri, Amirreza Javadi Mamaghani, Bahman Rahimi Esboei   +7 more
doaj   +1 more source

Efficacy and safety of chloroquine or hydroxychloroquine in moderate type of COVID-19: a prospective open-label randomized controlled study

medRxiv, 2020
The outbreak of novel coronavirus disease 2019 (COVID-19) has become a pandemic. Drug repurposing may represent a rapid way to fill the urgent need for effective treatment.
Lan Chen, Zhen-Yu Zhang, Jianguo Fu, Z. Feng, Su-zhen Zhang, Qiu-Ying Han, Xiao-bin Zhang, X. Xiao, Huiheng Chen, Li-Long Liu, Xiang Chen, Yuanbo Lan, D. Zhong, Lan Hu, Jun-hui Wang, Xing-Hua Yu, D. She, Yong-Hong Zhu, Zhen-yu Yin   +18 more
semanticscholar   +1 more source