Results 131 to 140 of about 79,424 (330)

In Situ and Real‐Time Multi‐Modality Imaging Guided Orderly Triple‐Therapy of Tumors with a Multifunctional Nanodrug

open access: yesAdvanced Science, Volume 12, Issue 25, July 3, 2025.
A multifunctional AuNR@SiO2@MnO2@ DNA prodrugs (ASMD) nanodrug is designed to establish an in situ and real‐time photoacoustic (PA)/magnetic resonance (MR)/fluorescence (FL) multi‐modality imaging guided orderly photothermal therapy (PTT)/chemodynamic therapy (CDT)/gene therapy (GT) triple‐therapy of tumor.
Chaoyi Yang   +10 more
wiley   +1 more source

Productivity of key informants for identifying blind children: evidence from a pilot study in Malawi.

open access: yes, 2009
OBJECTIVES: To determine the productivity of village-based 'key informants' (KIs) in identifying blind children. MATERIALS AND METHODS: Ngabu subdistrict (population 101,000) of Chikwawa district was divided into KI catchment areas.
Courtright, P   +3 more
core   +1 more source

Elasticity‐Driven Nanomechanical Interaction to Improve the Targeting Ability of Lipid Nanoparticles in the Malignant Tumor Microenvironment

open access: yesAdvanced Science, Volume 12, Issue 26, July 10, 2025.
The elasticity of lipid nanoparticles (LNPs) is essential to their tumor‐targeting efficacy. Softer LNPs penetrate tumors faster and more easily enter into softer cancer cells, while stiffer LNPs show prolonged retention in stiffer tumors. The presence of protumoral M2 macrophages enhances the LNPs uptake into stiffer cancer cells, facilitating ...
Eunhee Lee   +5 more
wiley   +1 more source

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

open access: yesBritish Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2028-2044, July 2025.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia   +4 more
wiley   +1 more source

Pharmacology and relevant drug interactions of metamizole

open access: yesBritish Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2095-2102, July 2025.
Metamizole is a frequently prescribed analgesic because of its favourable benefit/risk ratio compared with classic NSAIDs. However, increasing research shows that metamizole displays several drug interactions that are relevant to clinical practice. We reviewed the literature to summarize the pharmacology and most clinically relevant drug interactions ...
David J. Brinkman   +3 more
wiley   +1 more source

Allergy to chlorpromazine and valproic acid following carbamazepine hypersensitivity in a patient with an HLA-B*4601 allele

open access: yesNeuropsychiatric Disease and Treatment, 2018
Kumi Sakurada,1,* Takeshi Kozaru,2,* Kazuo Yamada,1 Masashi Nibuya,1 Kiyoshi Nagata,3 Eiji Suzuki1 1Department of Psychiatry, 2Department of Dermatology, 3Department of Environmental and Health Science, Tohoku Medical and Pharmaceutical University ...
Sakurada K   +5 more
doaj  

Electrochemical oxidation of Fe (II) using chlorpromazine drug at boron-doped diamond electrode: application to in vivo mechanism study interaction of chlorpromazine on hemoglobin iron and evaluation of some biomolecules

open access: yesMaterials Research Express
In this study, the electrochemical properties of aqueous chlorpromazine hydrochloride (CPZ) in the presence of Fe (II) were investigated by cyclic voltammetry at a boron-doped diamond (BDD) electrode.
Nader Amini   +7 more
doaj   +1 more source

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