Results 21 to 30 of about 51,092 (216)

Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Improved Oral Bioavailability of Chlorpromazine: In Vitro and In Vivo Evaluation

Medicina, 2019
Background and Objectives: Lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) have resurged the eminence of nanoemulsions by modest adjustments and offer many valuable opportunities in drug delivery.
Jeand Baloch, M. Sohail, Hafiz Sarwar, M. H. Kiani, G. Khan, S. Jahan, M. Rafay, M. T. Chaudhry, M. Yasinzai, G. Shahnaz   +9 more
semanticscholar   +1 more source

Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review

Frontiers in Cardiovascular Medicine, 2021
Pheochromocytoma multisystem crisis (PMC) is a potentially lethal emergency due to catecholamine secretion. The condition manifests as severe hypertension to intractable cardiogenic shock and has a high mortality rate.
James Jiqi Wang, James Jiqi Wang, Zuowen He, Zuowen He, Yan Yang, Bo Yu, Bo Yu, Hong Wang, Hong Wang, Hu Ding, Hu Ding, Guanglin Cui, Guanglin Cui, Luyun Wang, Luyun Wang, Dao Wen Wang, Dao Wen Wang, Jiangang Jiang, Jiangang Jiang   +18 more
doaj   +1 more source

Pencil graphite electrode as an electrochemical sensor for the voltammetric determination of chlorpromazine

Journal of Science: Advanced Materials and Devices, 2018
A selective, simple and sensitive electrochemical sensor has been developed using pencil leads (pencil graphite electrode, PGE) for the investigation of chlorpromazine (CPZ). The cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques
H. Purushothama, Y. A. Nayaka, M. Vinay, P. Manjunatha, R. O. Yathisha, K. V. Basavarajappa   +5 more
semanticscholar   +1 more source

Salivary flow rate and decayed, missing, and filled teeth (DMFT) in female patients with schizophrenia on chlorpromazine therapy

Journal of Dental Sciences, 2013
Background/purpose: The purpose of the study was to investigate relationship between saliva flow rates, estrogen levels, and caries prevalence in female psychiatric patients under antipsychotic therapy.
Jelena Krunić, Nikola Stojanović, Nedeljka Ivković, Dragica Stojić   +3 more
doaj   +1 more source

The Effects of Chlorpromazine on Reproductive System and Function in Female Rats [PDF]

International Journal of Fertility and Sterility, 2015
Background Chlorpromazine (CPZ), an antipsychotic drug, is associated with increased risk of sexual dysfunction through increasing prolactin levels. The current study evaluates the effect of CPZ-induced hyperprolactinemia on ovarian follicular growth ...
Zahra Zamani, Samad Zare, Rajabali Sadrkhanlou, Abbas Ahmadi, Elham Movahed   +4 more
doaj   +1 more source

Valbenazine induced acute parkinsonism in a patient with alcohol use disorder and central pontine myelinolysis. [PDF]

PCN Rep
Abstract Background Valbenazine is used to treat dyskinesia and is generally associated with limited side effects; however, a few cases with the adverse effect of parkinsonism are reported in the literature. In this study, we report a case of valbenazine‐induced acute parkinsonism.
Nagai Y, Mamiko M, Miyakawa K.
europepmc   +2 more sources

Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing

Scientific Reports, 2018
Parasitic helminths infect over 1 billion people worldwide, while current treatments rely on a limited arsenal of drugs. To expedite drug discovery, we screened a small-molecule library of compounds with histories of use in human clinical trials for ...
J. Weeks, W. M. Roberts, Caitlyn Leasure, Brian M. Suzuki, Kristin J. Robinson, Heather N Currey, P. Wangchuk, R. Eichenberger, Aleen D. Saxton, T. Bird, B. Kraemer, A. Loukas, J. Hawdon, C. Caffrey, Nicole F. Liachko   +14 more
semanticscholar   +1 more source

Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit

OncoTarget, 2017
Patients with glioblastoma have one of the lowest overall survival rates among patients with cancer. Standard of care for patients with glioblastoma includes temozolomide and radiation therapy, yet 30% of patients do not respond to these treatments and ...
C. Oliva, Wei Zhang, C. Langford, M. Suto, Corinne E. Griguer   +4 more
semanticscholar   +1 more source

Testing the Protective Effects of Sulfobutylether-Βeta-Cyclodextrin (SBECD) and Sugammadex against Chlorpromazine-Induced Acute Toxicity in SH-SY5Y Cell Line and in NMRI Mice

Pharmaceutics, 2022
Chlorpromazine (CPZ) is an antipsychotic drug which can cause several adverse effects and drug poisoning. Recent studies demonstrated that CPZ forms highly stable complexes with certain cyclodextrins (CDs) such as sulfobutylether-β-CD (SBECD) and ...
Eszter Fliszár-Nyúl, Rita Csepregi, Gábor Benkovics, Lajos Szente, Miklós Poór   +4 more
doaj   +1 more source

Development and Evaluation of an FDM Printed Nasal Device for CPZ Solid Nanoparticles

Molecules, 2023
Nasal drug delivery has been a focus of scientific interest for decades. A number of drug delivery systems and devices are available and have been highly successful in providing better and more comfortable therapy. The benefits of nasal drug delivery are
Thinh To Quoc, Krisztina Bíró, Ágota Pető, Dóra Kósa, Dávid Sinka, István Lekli, Attila Kiss-Szikszai, István Budai, Mónika Béres, Miklós Vecsernyés, Pálma Fehér, Ildikó Bácskay, Zoltán Ujhelyi   +12 more
doaj   +1 more source