Results 21 to 30 of about 82,153 (289)

Dynamic Changes in Plasma Metabolic Profiles Reveal a Potential Metabolite Panel for Interpretation of Fatal Intoxication by Chlorpromazine or Olanzapine in Mice

Metabolites, 2022
Diagnosing the cause of fatal intoxication by antipsychotic agents is an important task in forensic practice. In the 2020 Annual Report of the American Association of Poison Control Centers, among 40 deaths caused by antipsychotics, 21 cases were ...
Rui Bai, Xiaohui Dai, Xingang Miao, Bing Xie, Feng Yu, Bin Cong, Di Wen, Chunling Ma   +7 more
doaj   +1 more source

Repurposing chlorpromazine in the treatment of glioblastoma multiforme: analysis of literature and forthcoming steps

Journal of experimental & clinical cancer research : CR, 2020
Glioblastoma multiforme is a CNS cancer characterized by diffuse infiltrative growth, aggressive clinical behavior and very poor prognosis. The state-of-art clinical approach to this disease consists of surgical resection followed by radiotherapy plus ...
C. Abbruzzese, S. Matteoni, M. Persico, V. Villani, M. G. Paggi   +4 more
semanticscholar   +1 more source

A single blind comparative clinical study of the effects of chlorpromazine and risperidone on positive and negative symptoms in patients of schizophrenia

Indian Journal of Psychological Medicine, 2011
Objectives: The present study was undertaken to test the comparative efficacy of chlorpromazine and risperidone in patients of schizophrenia in a tertiary care hospital of Maharashtra.
Amrita Prakash Singam, Abhishek Mamarde, Prakash B Behere   +2 more
doaj   +1 more source

Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review

Frontiers in Cardiovascular Medicine, 2021
Pheochromocytoma multisystem crisis (PMC) is a potentially lethal emergency due to catecholamine secretion. The condition manifests as severe hypertension to intractable cardiogenic shock and has a high mortality rate.
James Jiqi Wang, James Jiqi Wang, Zuowen He, Zuowen He, Yan Yang, Bo Yu, Bo Yu, Hong Wang, Hong Wang, Hu Ding, Hu Ding, Guanglin Cui, Guanglin Cui, Luyun Wang, Luyun Wang, Dao Wen Wang, Dao Wen Wang, Jiangang Jiang, Jiangang Jiang   +18 more
doaj   +1 more source

TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243] [PDF]

, 2002
Agitated or violent patients constitute 10% of all emergency psychiatric treatment. Management guidelines, the preferred treatment of clinicians and clinical practice all differ.
A Jablensky, B Thornley, CB Joy, Clive E Adams, E Coutinho, Evandro SF Coutinho, Expert Consensus Guideline Group, F Moritz, G Huf, Gisele Huf, HI Kaplan, J Ludbrook, JG Cunnane, LS Pilowsky, M Fenton, M Hotopf, M Wyant, P Armitage, RL Binder, The Royal College of Psychiatrists, VW Berger, Z Atakan   +21 more
core   +3 more sources

Characterization of Zika virus endocytic pathways in human glioblastoma cells [PDF]

, 2020
Zika virus (ZIKV) infections can cause microcephaly and neurological disorders. However, the early infection events of ZIKV in neural cells remain to be characterized. Here, by using a combination of pharmacological and molecular approaches and the human
Du, T, Fu, M, Griffin, GE, Hu, Q, Li, C, Li, M, Liu, Y, Ni, F, Wang, H, Zhang, D, Zhang, M, Zheng, Z   +11 more
core   +1 more source

Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Improved Oral Bioavailability of Chlorpromazine: In Vitro and In Vivo Evaluation

Medicina, 2019
Background and Objectives: Lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) have resurged the eminence of nanoemulsions by modest adjustments and offer many valuable opportunities in drug delivery.
Jeand Baloch, M. Sohail, Hafiz Sarwar, M. H. Kiani, G. Khan, S. Jahan, M. Rafay, M. T. Chaudhry, M. Yasinzai, G. Shahnaz   +9 more
semanticscholar   +1 more source

Efficacy and safety of chlorpromazine as an adjuvant therapy for glioblastoma in patients with unmethylated MGMT gene promoter: RACTAC, a phase II multicenter trial

Frontiers in Oncology, 2023
IntroductionDrug repurposing is a promising strategy to develop new treatments for glioblastoma. In this phase II clinical trial, we evaluated the addition of chlorpromazine to temozolomide in the adjuvant phase of the standard first-line therapeutic ...
Andrea Pace, Giuseppe Lombardi, Veronica Villani, Dario Benincasa, Claudia Abbruzzese, Ilaria Cestonaro, Martina Corrà, Marta Padovan, Giulia Cerretti, Mario Caccese, Antonio Silvani, Paola Gaviani, Diana Giannarelli, Gennaro Ciliberto, Marco G. Paggi   +14 more
doaj   +1 more source

A Systematic Review of therapeutic agents for the treatment of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]

, 2019
Background The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first described in 2012 and attracted a great international attention due to multiple healthcare associated outbreaks.
Al-Ali, Anfal Y., Al-Tawfiq, Jaffar A., Momattin, Hisham   +2 more
core   +1 more source

Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing [PDF]

, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo.
Martínez Sayé, Melisa Soledad, Miranda, Mariana Reneé, Pereira, Claudio Alejandro, Phanstiel, Otto, Reigada, Chantal, Valera Vera, Edward Augusto   +5 more
core   +1 more source