Results 31 to 40 of about 82,153 (289)

Discriminating Different Classes of Toxicants by Transcript Profiling [PDF]

, 2004
Male rats were treated with various model compounds or the appropriate vehicle controls. Most substances were either well-known hepatotoxicants or showed hepatotoxicity during preclinical testing.
Albertini, Silvio, Boess, Franziska, de Vera, Maria Cristina, Gasser, Rodolfo, Ruepp, Stefan, Steiner, Guido, Suter, Laura   +6 more
core   +2 more sources

The Effects of Chlorpromazine on Reproductive System and Function in Female Rats [PDF]

International Journal of Fertility and Sterility, 2015
Background Chlorpromazine (CPZ), an antipsychotic drug, is associated with increased risk of sexual dysfunction through increasing prolactin levels. The current study evaluates the effect of CPZ-induced hyperprolactinemia on ovarian follicular growth ...
Zahra Zamani, Samad Zare, Rajabali Sadrkhanlou, Abbas Ahmadi, Elham Movahed   +4 more
doaj   +1 more source

Testing the Protective Effects of Sulfobutylether-Βeta-Cyclodextrin (SBECD) and Sugammadex against Chlorpromazine-Induced Acute Toxicity in SH-SY5Y Cell Line and in NMRI Mice

Pharmaceutics, 2022
Chlorpromazine (CPZ) is an antipsychotic drug which can cause several adverse effects and drug poisoning. Recent studies demonstrated that CPZ forms highly stable complexes with certain cyclodextrins (CDs) such as sulfobutylether-β-CD (SBECD) and ...
Eszter Fliszár-Nyúl, Rita Csepregi, Gábor Benkovics, Lajos Szente, Miklós Poór   +4 more
doaj   +1 more source

Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner [PDF]

, 2016
Cannabinoid receptor interacting protein 1a (CRIP1a) is a CB1 receptor (CB1R) distal C-terminus-associated protein that modulates CB1R signaling via G proteins, and CB1R down-regulation but not desensitization (Blume et al.
Bass, Caroline E., Blumes, Lawrence C, Chen, Rong, Howlett, Allyn C., Leone-Kabler, Sandra, Luessen, Deborah J., Lyons, Erica, Marrs, Glenn S., Selley, Dana E.   +8 more
core   +2 more sources

Development and Evaluation of an FDM Printed Nasal Device for CPZ Solid Nanoparticles

Molecules, 2023
Nasal drug delivery has been a focus of scientific interest for decades. A number of drug delivery systems and devices are available and have been highly successful in providing better and more comfortable therapy. The benefits of nasal drug delivery are
Thinh To Quoc, Krisztina Bíró, Ágota Pető, Dóra Kósa, Dávid Sinka, István Lekli, Attila Kiss-Szikszai, István Budai, Mónika Béres, Miklós Vecsernyés, Pálma Fehér, Ildikó Bácskay, Zoltán Ujhelyi   +12 more
doaj   +1 more source

Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing

Scientific Reports, 2018
Parasitic helminths infect over 1 billion people worldwide, while current treatments rely on a limited arsenal of drugs. To expedite drug discovery, we screened a small-molecule library of compounds with histories of use in human clinical trials for ...
J. Weeks, W. M. Roberts, Caitlyn Leasure, Brian M. Suzuki, Kristin J. Robinson, Heather N Currey, P. Wangchuk, R. Eichenberger, Aleen D. Saxton, T. Bird, B. Kraemer, A. Loukas, J. Hawdon, C. Caffrey, Nicole F. Liachko   +14 more
semanticscholar   +1 more source

Salivary flow rate and decayed, missing, and filled teeth (DMFT) in female patients with schizophrenia on chlorpromazine therapy

Journal of Dental Sciences, 2013
Background/purpose: The purpose of the study was to investigate relationship between saliva flow rates, estrogen levels, and caries prevalence in female psychiatric patients under antipsychotic therapy.
Jelena Krunić, Nikola Stojanović, Nedeljka Ivković, Dragica Stojić   +3 more
doaj   +1 more source

Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit

OncoTarget, 2017
Patients with glioblastoma have one of the lowest overall survival rates among patients with cancer. Standard of care for patients with glioblastoma includes temozolomide and radiation therapy, yet 30% of patients do not respond to these treatments and ...
C. Oliva, Wei Zhang, C. Langford, M. Suto, Corinne E. Griguer   +4 more
semanticscholar   +1 more source

Norepinephrine and dopamine increase motility, biofilm formation and virulence of Vibrio harveyi [PDF]

, 2014
Vibrio harveyi is one of the major pathogens of aquatic organisms, affecting both vertebrates and invertebrates, and causes important losses in the aquaculture industry.
Bossier, Peter, Defoirdt, Tom, Nguyen Duc, Quynh Anh, Yang, Qian   +3 more
core   +2 more sources

A dual dopaminergic therapy with L-3,4-dihydroxyphenylalanine and chlorpromazine for the treatment of blepharospasm, a focal dystonia: Possible implications for striosomal D1 signaling

Frontiers in Neurology, 2022
Impairment of balanced activity between dopamine D1 and D2 receptor functions in the striatum, particularly in striatal functional subdivisions (i.e., striosome and matrix compartments), has been proposed to underlie dystonia genesis.
Shinichi Matsumoto, Hidetaka Koizumi, Hideki Shimazu, Hideki Shimazu, Ryuji Kaji, Satoshi Goto, Satoshi Goto   +6 more
doaj   +1 more source