Results 71 to 80 of about 51,092 (216)

Synthesis of Sulfur Enriched Cyclohexenes via the Tungsten‐Promoted Dearomatization of a Phenyl Sulfone

European Journal of Organic Chemistry, Volume 29, Issue 9, 2 March 2026.
A method for synthesizing sulfur‐substituted cyclohexenes is reportedthat leverages the η2‐coordination of a phenyl sulfone to [WTp(NO)(PMe3)] (Tp = trispyrazolylborate). Three sequential protonation and nucleophilic additions to the bound arene, followed by oxidative decomplexation, affords functionalized cyclohexenes bearing sp3‐ and sulfur‐enriched ...
Daniel J. Siela, Matthew C. McGraw, Diane A. Dickie, W. Dean Harman   +3 more
wiley   +1 more source

Pattern of Psychotropic Drug Prescription in the Elderly with Chronic Schizophrenia

Iranian Rehabilitation Journal, 2013
Objectives: Psychotropic drug use in the elderly with chronic schizophrenia is an important issue in the field of psychiatry. The main goal of this study was to clarify the pattern of such drug use in these patients, in order to consider such therapy ...
Mohamad Reza Khodaei Ardakani, Arash Mirabzadeh, Hashem Shemshadi, Zabihollah Ashtari, Maryam Ranjbar, Golnaz Feizzadeh, Mercedeh Samiei, Alireza Khodaei Ardakani   +7 more
doaj  

Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase.

Journal of Biological Chemistry, 1980
Ca2+-activated, phospholipid-dependent protein kinase recently found in mammalian tissues (Takai, Y., Kishimoto, A., Iwasa, Y., Kawahara, Y., Mori, T., and Nishizuka, Y. (1979) J. Biol. Chem.
T. Mori, Y. Takai, R. Minakuchi, B. Yu, Y. Nishizuka   +4 more
semanticscholar   +1 more source

Intrinsically Disordered Protein‐Inspired Nanovector‐Based Coacervates for the Direct Cytosolic Transport of Biomacromolecules

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
Intrinsically disordered protein‐inspired nanovectors (IDP‐NVs) form stable nanocoacervates (NCs) with diverse biomacromolecules. In situ conformational changes confer stability and adaptability to NCs under dynamically changing physiological conditions.
Soyeong Jin, Hyemin Park, Seuk‐Min Ryu, Dagyeong Guk, Jaeeun Lee, Seongeon Jin, Changjoon Keum, Jinyoung Park, Myoung‐Hwan Park, Chaekyu Kim, Hojun Kim, Jaegeun Noh, Kwan Hyi Lee, Ja‐Hyoung Ryu, Youngdo Jeong   +14 more
wiley   +1 more source

Biochemical Pathways Triggered by Antipsychotics in Human Oligodendrocytes: Potential of Discovering New Treatment Targets

Frontiers in Pharmacology, 2019
Schizophrenia is a psychiatric disorder that affects more than 21 million people worldwide. It is an incurable disorder and the primary means of managing symptoms is through administration of pharmacological treatments, which consist heavily of ...
Caroline Brandão-Teles, Valéria de Almeida, Juliana S. Cassoli, Juliana S. Cassoli, Daniel Martins-de-Souza, Daniel Martins-de-Souza, Daniel Martins-de-Souza   +6 more
doaj   +1 more source

High‐Throughput In Vivo Subcellular Analysis of Gold Nanoparticles for Tumor Mitochondrial Targeting

Advanced Materials, Volume 38, Issue 16, 17 March 2026.
A DNA barcoding system enables high‐throughput in vivo screening of mitochondrial‐targeting gold nanoparticles. Thirty nanoparticle types with varied shapes, sizes, and ligands are individually barcoded and pooled. The pooled library is administered to tumor‐bearing mice, and barcodes retrieved from tumor mitochondria are amplified and sequenced to ...
Xingyue Huang, Xuehao Tian, Kuei Chen, Yang Wu, ChenCheng Xue, Yingjie Quek, Jessalyn Low, Arun Kumar, Andy Tay   +8 more
wiley   +1 more source

Chlorpromazine as prophylaxis for bipolar disorder with treatment- and electroconvulsive therapy-refractory mania: Old horse, new trick

Indian Journal of Psychological Medicine, 2017
A 22-year-old male diagnosed with bipolar affective disorder presented to us with a 3rd episode mania resistant to both olanzapine and haloperidol as well as electroconvulsive therapy.
Tamonud Modak, Saurabh Kumar, Arghya Pal, Rishab Gupta, Raman Deep Pattanayak, Sudhir Kumar Khandelwal   +5 more
doaj   +1 more source

AIE‐Active Cationic Tripyrrole Targeting Mitochondrial SDHAF1 for Acute Myeloid Leukemia Therapy

Aggregate, Volume 7, Issue 3, March 2026.
Cationic tripyrrole oligomers (Tri‐DPPy) selectively accumulate in mitochondria and suppress Complex II activity by binding to SDHAF1, thereby effectively eradicating AML cells both in vitro and in vivo. ABSTRACT Therapy‐resistant acute myeloid leukemia (AML) depends on mitochondrial oxidative phosphorylation (OXPHOS) to meet its energy demands, and ...
Wangxing Lin, Jun Cheng, Jingqin Chen, Weimin Xiao, Jiarui Li, Xiaoqi Wang, Meng Gao   +6 more
wiley   +1 more source

Antibacterial Activity of a Mouthwash Containing Plectranthus amboinicus (Lour.) Spreng Extract and Lippia sidoides Cham. Essential Oil

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
Plant‐Based Antibacterial Mouthwash. ABSTRACT This study investigated the development of a mouthwash formulated with Plectranthus amboinicus leaf extract (PaEE) and Lippia sidoides leaf essential oil (LsOE), exploring their antibacterial potential.
Wilma Francisca da Silva, Carla de Fatima Alves Nonato, Débora Odília Duarte Leite, Fabiola Fernandes Galvão Rodrigues, Fazia Fernandes Galvão Rodrigues, Ana Cecília Calixto Donelardy, José Galberto Martins da Costa   +6 more
wiley   +1 more source

Comparison of intramuscular haloperidol and other short-acting injectable antipsychotics for management of acute agitation in an adult inpatient psychiatry unit [PDF]

Mental Health Clinician
Introduction There is no consensus on the optimal antipsychotic for acute agitation. Whereas haloperidol is frequently used and has proven efficacy, second generation antipsychotics show similar efficacy and improved safety and tolerability.
Sarah Gamcsik, PharmD, Katie S. Adams, PharmD, BCPP, BCPS   +1 more
doaj   +1 more source