Acta Pharmaceutica Sinica B, 2022 Sulfonylureas are widely used oral anti-diabetic drugs. However, its long-term usage effects on patients’ lifespan remain controversial, with no reports of influence on animal longevity.
Zhifan Mao +8 more
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Verification of the folkloric and anecdotal antidiabetic effects of Hypoxis hemerocallidea (Fisch., C.A. Mey. & Avé-Lall) and isolated, β-sitosterol using early-stage type II spontaneous diabetic mutant BKS-Lepr db mice [PDF]
BMC Complementary Medicine and Therapies, 2022 Background Previous studies in our laboratory in ex vivo assays have demonstrated H. hemerocallidea extract as potential antidiabetic agent through increased insulin release from pancreatic beta cells.
N. M. Mkolo +5 more
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Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets [PDF]
Frontiers in ImmunologyBackgroundType 2 Diabetes Mellitus (T2DM) represents a major global health challenge, marked by chronic hyperglycemia, insulin resistance, and immune system dysfunction.
Huahua Li +4 more
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Four functional genotoxic marker genes (Bax, Btg2, Ccng1, and Cdkn1a) discriminate genotoxic hepatocarcinogens from non-genotoxic hepatocarcinogens and non-genotoxic non-hepatocarcinogens in rat public toxicogenomics data, Open TG-GATEs [PDF]
Genes and EnvironmentBackground Previously, Japanese Environmental Mutagen and Genome Society/Mammalian Mutagenicity Study Group/Toxicogenomics Study Group (JEMS/MMS toxicogenomic study group) proposed 12 genotoxic marker genes (Aen, Bax, Btg2, Ccnf, Ccng1, Cdkn1a, Gdf15 ...
Chie Furihata, Takayoshi Suzuki
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Chlorpropamide-induced thrombocytopenia [PDF]
Postgraduate Medical Journal, 1977 Summary Thrombocytopenia is a rare complication of chlorpropamide therapy. An immunological mechanism is generally held responsible, but has never previously been proved. In the present case the existence of such a mechanism has been established.
D J, Cunliffe, D W, Gorst, H M, Palmer
openaire +4 more sources
Solids Turn into Liquids—Liquid Eutectic Systems of Pharmaceutics to Improve Drug Solubility
Pharmaceuticals, 2022 The low solubility of active pharmaceutical ingredients (APIs) is a problem in pharmaceutical development. Several methodologies can be used to improve API solubility, including the use of eutectic systems in which one of the constituents is the API ...
Mafalda C. Sarraguça +3 more
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Heliyon, 2021 Introduction: Increase in the prevalence of type-2 diabetes in Sub-Sahara Africa has created the need for robust treatment and management programs. However, an effective diabetes management program requires a high annual budget that most countries in ...
Isaac Kyei-Barffour +8 more
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Crystal structure of 4-bromo-N-(propylcarbamoyl)benzenesulfonamide
Acta Crystallographica Section E: Crystallographic Communications, 2022 The title compound, C10H13BrN2O3S, 1, contains a sulfonyl urea moiety, which possesses potential therapeutic functions (e.g., anti-diabetic and herbicidal).
Mustafa Bookwala +3 more
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