Results 241 to 250 of about 644,201 (301)

Mediated Electrochemical Probing and Machine Learning for Cysteine and Reduced Monoclonal Antibody Quantification

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Biopharmaceutical manufacturing requires robust analytics and process controls throughout production to insure high yield of quality products. New methodologies for rapidly accessing and integrating data‐rich information from complex dynamic biological environments are of great interest.
Kayla Chun, Varun Kochar, Evelyn Jaskowiak, Chen‐Yu Chen, Divya Muthusamy, Dana Motabar, Eunkyoung Kim, Gregory F. Payne, William E. Bentley   +8 more
wiley   +1 more source

Building blocks needed for mechanistic modeling of bioprocesses: A critical review based on protein production by CHO cells. [PDF]

Metab Eng Commun
González-Hernández Y, Perré P.
europepmc   +1 more source

Construction of a novel kinetic model for the production process of a CVA6 VLP vaccine in CHO cells. [PDF]

Cytotechnology
Xing Z, Nguyen TB, Kanai-Bai G, Yamano-Adachi N, Omasa T.   +4 more
europepmc   +1 more source

Enhancing Human Glycoprotein Hormones Production in CHO Cells Using Heterologous Beta-Chain Signal Peptides. [PDF]

Dokl Biochem Biophys
Sinegubova MV, Kolesov DE, Dayanova LK, Vorobiev II, Orlova NA.   +4 more
europepmc   +1 more source

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Chromosome stability in CHO cells

Somatic Cell Genetics, 1977
The established cell line derived many years ago from Chinese hamster ovary (CHO cells) has been studied for the extent of chromosomal variation. Because this cell line is used extensively for genetic studies, the contribution of chromosome variability to genetic variability has also been examined. The quasidiploid CHO cells were found to have a banded
R G, Worton, C C, Ho, C, Duff
openaire   +2 more sources

DNA methylation in CHO cells

Journal of Biotechnology, 2017
Chinese hamster ovary (CHO) cells account for the production of the majority of biopharmaceutical molecules - however, the molecular basis for their versatile properties is not entirely understood yet and the underlying cellular processes need to be characterized in detail.
Wippermann, Anna, Noll, Thomas
openaire   +2 more sources

Dynamic model of CHO cell metabolism

Metabolic Engineering, 2011
Fed-batch cultures are extensively used for the production of therapeutic proteins. However, process optimization is hampered by lack of quantitative models of mammalian cellular metabolism in these cultures. This paper presents a new kinetic model of CHO cell metabolism and a novel framework for simulating the dynamics of metabolic and biosynthetic ...
Ryan P, Nolan, Kyongbum, Lee
openaire   +2 more sources

Misonidazole-glutathione conjugates in CHO cells

International Journal of Radiation Oncology*Biology*Physics, 1984
Misonidazole, after reduction to the hydroxylamine derivative, reacts with glutathione (GSH) under physiological conditions. The reaction product has been identified as a mixture of two isomeric conjugates. When water soluble extracts of CHO cells exposed to misonidazole under hypoxic conditions are subjected to HPLC analysis, misonidazole derivatives,
A J, Varghese, G F, Whitmore
openaire   +2 more sources

Dynamic model for CHO cell engineering

Journal of Biotechnology, 2012
Industrial CHO cell fed-batch processes have progressed significantly over the past decade, with recombinant protein titer consistently reaching the gram per liter level. Such improvements have largely resulted from separate advances in process and cell line development.
Ryan P, Nolan, Kyongbum, Lee
openaire   +2 more sources

Synthetic promoters for CHO cell engineering

Biotechnology and Bioengineering, 2014
ABSTRACTWe describe for the first time the creation of a library of 140 synthetic promoters specifically designed to regulate the expression of recombinant genes in CHO cells. Initially, 10 common viral promoter sequences known to be active in CHO cells were analyzed using bioinformatic sequence analysis programs to determine the identity and relative ...
Adam J, Brown, Bernie, Sweeney, David O, Mainwaring, David C, James   +3 more
openaire   +2 more sources