Results 241 to 250 of about 188,771 (295)

Engineering Decavalent, Sperm‐Binding Laminin‐IgG Hybrid Antibodies for Potent Non‐Hormonal Contraception

open access: yesAdvanced Science, EarlyView.
This study investigates a highly multivalent mAb platform fusing Laminin‐511 heterotrimerization domains with Fabs and IgG1‐Fc as a non‐hormonal contraceptive. The most potent molecule ‘LamH10’, possessing 10 Fabs, rapidly achieved >99% reduction in progressively motile sperm at just 33µg per dose in sheep, making the laminin‐IgG hybrid platform the ...
Alison Schaefer   +8 more
wiley   +1 more source

Rapid‐Turnaround Co‐Administration of mRNA‐Based MHC‐I and MHC‐II‐Restricted Neoantigens Enhances Immune Responses of Antigen‐Specific CD8+ T Cells and Anti‐Cancer Efficacy in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
Co‐administration with MHC class I‐ and II‐restricted neoantigens encoding mRNA‐based personalized cancer vaccines in a mouse CRC model can induce antigen‐specific immune responses and anti‐cancer effects. Notably, vaccination at an early stage of cancer development can have potent anti‐cancer effects. Furthermore, combining mRNA with immune checkpoint
Seongje Cho   +26 more
wiley   +1 more source

Enhancing Human Glycoprotein Hormones Production in CHO Cells Using Heterologous Beta-Chain Signal Peptides. [PDF]

open access: yesDokl Biochem Biophys
Sinegubova MV   +4 more
europepmc   +1 more source

Isolation of the serotoninergic 5‐HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6‐glial and CHO cell lines

open access: green, 2000
Jeanne Mialet‐Perez   +11 more
openalex   +2 more sources

Simple Protein Foaming‐Derived 3D Segregated MgO Networks in Epoxy Composites with Outstanding Thermal Conductivity Properties

open access: yesAdvanced Science, EarlyView.
MgO‐based composites with highly interconnected filler networks are fabricated using a simple, eco‐friendly protein foaming method. Liquid‐phase‐assisted sintering enhanced bonding with the matrix. The interconnected structured filler composites exhibit significantly improved thermal conductivity, exceeding that of pure epoxy, randomly dispersed ...
Su‐Jin Ha   +6 more
wiley   +1 more source

MXene‐Engineered Cs2AgBiBr6 Perovskite Solar Cells: Rational Screening and Interfacial Dynamics for Lead‐Free Photovoltaics

open access: yesAdvanced Science, EarlyView.
The first strategic screening of M2X‐type MXenes for heterojunction design with Cs2AgBiBr6 is investigated by theory and experimental validation, revealing the role of transition metal layers, surface terminations, and work functions in enhanced photovoltaic performances.
Lin Yang   +10 more
wiley   +1 more source

New Strategy for Cluster‐Based Covalent Organic Framework: Thermally Induced Covalent Crosslinking of Highly Stable Copper Clusters

open access: yesAdvanced Science, EarlyView.
A thermally induced covalent crosslinking strategy is used to accelerate the photogenerated carrier transport of cluster‐based photocatalysts, the covalent crosslinking between clusters accelerates the dynamic transfer of photoexcited charge carriers, increases the light utilization ability, and favors CO2 adsorption as well as *COOH generation, which ...
Jian‐Peng Dong   +6 more
wiley   +1 more source

Nanoshield‐Assisted Viral Gene Therapy with Induction of Non‐Apoptotic Cell Death and Durable Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
A novel hybrid gene delivery platform combines adeno‐associated virus (AAV)‐mediated receptor‐interacting kinase 3 (RIPK3) expression with manganese dioxide‐polyethyleneimine (MnO2−PEI) nanoshield to induce necroptosis, ferroptosis, and immunogenic cell death, effectively reprogramming the tumor microenvironment.
Soo‐Hwan Lee   +8 more
wiley   +1 more source

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