Results 251 to 260 of about 228,451 (311)

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +1 more source

Recent advances in culture medium design for enhanced production of monoclonal antibodies in CHO cells: A comparative study of machine learning and systems biology approaches. [PDF]

Biotechnol Adv
Kavoni H, Savizi ISP, Lewis NE, Shojaosadati SA.   +3 more
europepmc   +1 more source

Exploiting non-permissive CHO cells as a rapid and efficient method for recombinant HSV-1 isolation. [PDF]

AMB Express
Kelishadi M, Shahsavarani H, Tabarraei A, Shokrgozar MA, Rahimi A, Teimoori-Toolabi L, Azadmanesh K.   +6 more
europepmc   +1 more source

Stable overexpression of native and artificial miRNAs for the production of differentially fucosylated antibodies in CHO cells. [PDF]

Eng Life Sci
Schlossbauer P, Naumann L, Klingler F, Burkhart M, Handrick R, Korff K, Neusüß C, Otte K, Hesse F.   +8 more
europepmc   +1 more source

Increased stable integration efficiency in CHO cells through enhanced nuclear localization of Bxb1 serine integrase. [PDF]

BMC Biotechnol
Huhtinen O, Prince S, Lamminmäki U, Salbo R, Kulmala A.   +4 more
europepmc   +1 more source

Effects of autophagy-inhibiting chemicals on sialylation of Fc-fusion glycoprotein in recombinant CHO cells. [PDF]

Appl Microbiol Biotechnol
Lee HM, Park JH, Kim TH, Kim HS, Kim DE, Lee MK, You J, Lee GM, Kim YG.   +8 more
europepmc   +1 more source

DNA methylation in CHO cells [PDF]

Journal of Biotechnology, 2017
Chinese hamster ovary (CHO) cells account for the production of the majority of biopharmaceutical molecules - however, the molecular basis for their versatile properties is not entirely understood yet and the underlying cellular processes need to be characterized in detail.
Wippermann, Anna, Noll, Thomas
openaire   +3 more sources

Selenalysine utilization by CHO cells. [PDF]

Physiological chemistry and physics and medical NMR, 1987
CHO cells allowed to grow in a medium containing selenalysine can utilize it for protein synthesis. Selenalysine is incorporated into cell proteins in substitution of lysine: a maximum of 5% of protein lysine can be substituted. Protein lysine substitution by selenalysine can be correlated to the reduced viability of cells grown in its presence.
C. D. Marco, CINI, Chiara, BLARZINO, Carla, V. Busiello, M. D. Girolamo   +4 more
openaire   +3 more sources

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Chromosome stability in CHO cells

Somatic Cell Genetics, 1977
The established cell line derived many years ago from Chinese hamster ovary (CHO cells) has been studied for the extent of chromosomal variation. Because this cell line is used extensively for genetic studies, the contribution of chromosome variability to genetic variability has also been examined. The quasidiploid CHO cells were found to have a banded
R G, Worton, C C, Ho, C, Duff
openaire   +2 more sources

Genotoxic effects of ketamine on CHO cells

Archives of Toxicology, 1986
Ketamine, a non-barbiturate anaesthetic agent, was studied for its genotoxic potential using the SCE assay. It was genotoxic in the in vitro system at concentrations comparable to the plasma levels achieved during steady state anaesthesia. It had no effects on cellular kinetics in CHO cells.
S G, Adhvaryu, A H, Trivedi, K H, Jani, R C, Vyas, B J, Dave   +4 more
openaire   +2 more sources