Results 81 to 90 of about 3,708,398 (246)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Reducing the Consumer Attitude–Behaviour Gap in Animal Welfare: The Potential Role of ‘Nudges’
Animals, 2018 Citizen concern for the welfare of farm animals is well documented. However, there is a notable gap between people saying they want improved farm animal welfare and how they actually behave as a consumer.
Belinda Vigors
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Christiano’s Deliberative Expertism and Choice Architecture
Anali Hrvatskog Politološkog Društva, 2015 The article explores Thomas Christiano’s account of the moral division of labor in democracy. Christiano’s incorporation of experts serves the purpose of alleviating the epistemic burdens of ordinary citizens in the decision-making process and decreasing
Viktor Ivanković
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Desperately seeking streaming: CHOICE digital consumers paying for content behaviour and attitudes
, 2015 Has the launch of new streaming services in Australia had an impact on the ways Australians access digital content or is a punitive regulatory approach necessary to reduce piracy?
Choice
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
NARAL Anti-Choice Scare Tactic Flyer
, 2017 Flyer denouncing anti-choice scare ...
NARAL Pro-Choice America
core
An Architecture Story: Engaging Design Through Storytelling [PDF]
, 2015 There are many historic pieces of architecture that are centuries old, but still somehow maintain the same level of magnificence and delight as they had when they were first completed.
Shek, Chuen Ho Howard
core +1 more source