Results 121 to 130 of about 8,895,325 (304)

Trust-Based Research: Influencing Factors of Patients' Medical Choice Behavior in the Online Medical Community. [PDF]

Healthcare (Basel), 2022
Qiu C, Zhang Y, Wang X, Gu D.
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Experienced entropy drives choice behavior in a boring decision-making task. [PDF]

Sci Rep, 2022
Seiler JP, Dan O, Tüscher O, Loewenstein Y, Rumpel S.   +4 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Machine learning with a snapshot of data: Spiking neural network 'predicts' reinforcement histories of pigeons' choice behavior. [PDF]

J Exp Anal Behav, 2022
Plessas A, Espinosa-Ramos JI, Parry D, Cowie S, Landon J.   +4 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Entropy-based metrics for predicting choice behavior based on local response to reward. [PDF]

Nat Commun, 2021
Trepka E, Spitmaan M, Bari BA, Costa VD, Cohen JY, Soltani A.   +5 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Descrição de algumas variáveis no comportamento de esperar por recompensas previamente escolhidas

Psicologia USP
O presente experimento foi realizado com o objetivo de verificar se a escolha por recompensas dependia do conhecimento da situação, de treino anterior em autocontrole, ou se a situação experimental favorecia a aprendizagem de autocontrole, definido como ...
Rachel Rodrigues Kerbauy, Marina Plastina Buzzo   +1 more
doaj  

The Impact of COVID-19 on Travel Mode Choice Behavior in Terms of Shared Mobility: A Case Study in Beijing, China. [PDF]

Int J Environ Res Public Health, 2022
Zhang X, Shao C, Wang B, Huang S.
europepmc   +1 more source