FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Trust-Based Research: Influencing Factors of Patients' Medical Choice Behavior in the Online Medical Community. [PDF]
Healthcare (Basel), 2022 Qiu C, Zhang Y, Wang X, Gu D.
europepmc +1 more source
Effects of alternative elicitation formats in discrete choice experiments [PDF]
An elicitation format prevalently applied in DCE is to offer each respondent a sequence of choice tasks containing more than two choice options.
Bennett, Jeffrey W., Scheufele, Gabriela
core +1 more source
Impact of Opioid Dose Reductions on Patient-Reported Mental Health and Suicide-Related Behavior and Relationship to Patient Choice in Tapering Decisions [PDF]
, 2023 Bobbi Jo H. Yarborough +8 more
openalex +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Experienced entropy drives choice behavior in a boring decision-making task. [PDF]
Sci Rep, 2022 Seiler JP +4 more
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Machine learning with a snapshot of data: Spiking neural network 'predicts' reinforcement histories of pigeons' choice behavior. [PDF]
J Exp Anal Behav, 2022 Plessas A +4 more
europepmc +1 more source
Heterogeneity in Risky Choice Behavior in a Broad Population [PDF]
We analyse risk preferences using an experiment with real incentives in a representative sample of 1,422 Dutch respondents. Our econometric model incorporates four structural parameters that vary with observed and unobserved characteristics: Utility ...
Gaudecker, H.M. von +2 more
core +1 more source
Learning a mixture of two multinomial logits [PDF]
, 2018 The classical Multinomial Logit (MNL) is a behavioral model for user choice. In this model, a user is offered a slate of choices (a subset of a finite universe of n items), and selects exactly one item from the slate, each with probability proportional ...
Chierichetti, Flavio +2 more
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