Results 131 to 140 of about 1,765,802 (336)

An automated home-cage-based 5-choice serial reaction time task for rapid assessment of attention and impulsivity in rats [PDF]

, 2019
Bastiaan Bruinsma, Huub Terra, Sybren F. de Kloet, Antonio Luchicchi, Axelle Timmerman, Esther Remmelink, Maarten Loos, Tommy Pattij, Huibert D. Mansvelder   +8 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

An adaptive paradigm for detecting the individual duration of the preparatory period in the choice reaction time task. [PDF]

PLoS One, 2022
Soghoyan G, Aksiotis V, Rusinova A, Myachykov A, Tumyalis A.   +4 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A Toy Model for Testing Finite Element Methods to Simulate Extreme-Mass-Ratio Binary Systems

, 2006
Extreme mass ratio binary systems, binaries involving stellar mass objects orbiting massive black holes, are considered to be a primary source of gravitational radiation to be detected by the space-based interferometer LISA.
Alpert B, Arnold D N, Babuška I Strouboulis T, Bank R, Bank R, Bank R E, Bank R E, Barack L, Barack L, Barack L, Bayliss A, Bayliss A, Beijing FEGEN Software Co. Ltd, Carlos F Sopuerta, Chen L, Chen L Xu J, Ciarlet P G, Cutler C, Danzmann K, Danzmann K, Detweiler S, Dolejsi V, Drasco S, Field D A, Freitag L A Jones M T Plassmann P E, Gair J R, Hough J Rowan S Sathyaprakash B, Hughes S A, Hughes S A, Hughes T J R, Jinchao Xu, Kornhuber R, Krivan W, Lau S R, Lawson C L, Lopez-Aleman R, Lousto C O, Lousto C O, Lousto C O, Metzger J, Mino Y, Mino Y, Mino Y, Mino Y, Misner C W, Morin P, Pablo Laguna, Pengtao Sun, Poisson E, Poisson E, Prince T, Quinn T C, Rivara M C, Rivara M C, Rivara M C, Sago N, Scheel M A, Shapiro S L, Shapiro S L, Shephard M, Shoemaker D, Strang G, Tanaka T, Teukolsky S A, Vitale S, Wahlbin L B, Xu J, Zienkiewicz O C, Zienkiewicz O C, Zienkiewicz O C   +69 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Sensitizing Regimen of Amphetamine Impairs Visual Attention in the 5-Choice Serial Reaction Time Test: Reversal by a D1 Receptor Agonist Injected into the Medial Prefrontal Cortex [PDF]

, 2006
Paul Fletcher, Catherine Tenn, Judy Sinyard, Zoë Rizos, Shitij Kapur   +4 more
openalex   +1 more source

Losing the error related negativity (ERN): an indicator for willed action

, 2001
When people make errors in a discrimination task, a negative-going waveform can be observed in scalp-recorded EEG that has been coined the error-related negativity (ERN). We hypothesized that the ERN only occurs with slips, that is unwilled action errors,
Schoenle, Paul Walter, Stemmer, Brigitte, Witzke, Wolfgang   +2 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source