Results 91 to 100 of about 89,075 (280)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Targeting cholangiocarcinoma

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018
Cholangiocarcinoma (CCA) represents a diverse group of epithelial cancers associated with the biliary tract, and can best be stratified anatomically into intrahepatic (iCCA), perihilar (pCCA) and distal (dCCA) subsets. Molecular profiling has identified genetic aberrations associated with these anatomic subsets.
Joachim C, Mertens, Sumera I, Ilyas, Gregory J, Gores   +2 more
openaire   +2 more sources

Bacterial Pigments as Potential Antitumor Agents Against Gastrointestinal Cancers: A Comprehensive Systematic Review

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Gastrointestinal cancers (GICs) constitute one of the leading causes of cancer‐related morbidity and mortality worldwide. Despite currently available therapeutic strategies, new approaches and procedures are needed for their prevention and treatment.
Raúl Vergara, Ricardo F. S. Pereira, Carla C. C. R. de Carvalho, Jose Prados, Consolación Melguizo, Raul Ortiz   +5 more
wiley   +1 more source

Status of oncology drugs with a conditional approval: A cross‐sectional comparison of the Food and Drug Administration and Health Canada

British Journal of Clinical Pharmacology, EarlyView.
Aims This study looks at the status of the same drugs conditionally approved by the Food and Drug Administration and Health Canada for the same oncology indication. Methods Lists of oncology drugs with a conditional approval from the Food and Drug Administration and Health Canada were generated and drug pairs with the same indication were matched ...
Joel Lexchin
wiley   +1 more source

Discovery of novel serum peptide biomarkers for cholangiocarcinoma recurrence through MALDI-TOF MS and LC–MS/MS peptidome analysis

Scientific Reports
Cholangiocarcinoma (CCA) is an aggressive cancer originating from bile duct epithelial cells, with a high rate of recurrence following surgical resection. Recurrence is categorized as early linked to aggressive tumor biology than late recurrence.
Vasin Thanasukarn, Piya Prajumwongs, Nattha Muangritdech, Watcharin Loilome, Nisana Namwat, Poramate Klanrit, Arporn Wangwiwatsin, Sawanya Charoenlappanit, Janthima Jaresitthikunchai, Sittiruk Roytrakul, Attapol Titapun   +10 more
doaj   +1 more source

Inhibition of -type amino acid transporter 1 activity as a new therapeutic target for cholangiocarcinoma treatment

Tumor Biology, 2017
Unlike normal cells, cancer cells undergo unlimited growth and multiplication, causing them to require massive amounts of amino acid to support their continuous metabolism. Among the amino acid transporters expressed on the plasma membrane, l- type amino
Supak Yothaisong, Hasaya Dokduang, Naohiko Anzai, Keitaro Hayashi, Nisana Namwat, Puangrat Yongvanit, Sakkarn Sangkhamanon, Promsuk Jutabha, Hitoshi Endou, Watcharin Loilome   +9 more
doaj   +1 more source

Overexpression of a panel of cancer stem cell markers enhances the predictive capability of the progression and recurrence in the early stage cholangiocarcinoma

Journal of Translational Medicine, 2020
Background Cancer recurrence is the important problem of cholangiocarcinoma (CCA) patients, lead to a very high mortality rate. Therefore, the identification of candidate markers to predict CCA recurrence is needed in order to effectively manage the ...
Sureerat Padthaisong, Malinee Thanee, Nisana Namwat, Jutarop Phetcharaburanin, Poramate Klanrit, Narong Khuntikeo, Attapol Titapun, Sakkarn Sungkhamanon, Hideyuki Saya, Watcharin Loilome   +9 more
doaj   +1 more source

Cholangiocarcinoma — novel biological insights and therapeutic strategies

Nature Reviews Clinical Oncology, 2023
S. Ilyas, Silvia Affò, L. Goyal, A. Lamarca, Gonzalo Sapisochin, J. D. Yang, G. Gores   +6 more
semanticscholar   +1 more source

Identification of Four Immune Subtypes Characterized by Distinct Composition and Functions of Tumor Microenvironment in Intrahepatic Cholangiocarcinoma

Hepatology, 2019
Intrahepatic cholangiocarcinoma (ICC) is a severe malignant tumor in which the standard therapies are mostly ineffective. The biological significance of the desmoplastic tumor microenvironment (TME) of ICC has been stressed but was insufficiently taken ...
S. Job, Delphine Rapoud, Alexandre Dos Santos, Patrick Gonzalez, C. Desterke, G. Pascal, N. Elarouci, M. Ayadi, R. Adam, D. Azoulay, C. Denis, E. Vibert, D. Cherqui, D. Samuel, A. Sa Cuhna, A. Marchio, P. Pineau, C. Guettier, A. de Reyniès, J. Faivre   +19 more
semanticscholar   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source