Results 51 to 60 of about 79,213 (303)

Cholangiocarcinoma: New insights [PDF]

, 2017
Cholangiocarcinoma is a malignant neoplasm originating from biliary epithelial cells. The incidence and mortality of this cancer are rising in the world. Currently, cholangiocarcinoma is accepted as a stem cell disease with many risk factors.
Göral, Vedat
core   +1 more source

An extremely rare case of intrahepatic sarcomatoid cholangiocarcinoma

, 2023
One uncommon histological subtype of intrahepatic cholangiocarcinoma is sarcomatoid intrahepatic cholangiocarcinoma. Histopathological and immunohistochemical tests are used to diagnose sarcomatoid intrahepatic cholangiocarcinoma, which frequently has a ...
Tran Ngoc Anh, MD, PhD, Dau Quang Lieu, MD, Tran-Thi Hoa, MD, Vu-Thi Phuong, MD, Nguyen Minh Duc, MD, Tran-Thi Hoa, Vu-Thi Phuong, Hoa, Tran-Thi, Anh, Tran Ngoc, Duc, Nguyen Minh, Nguyen Minh Duc, Lieu, Dau Quang, Tran Ngoc Anh, Phuong, Vu-Thi, Dau Quang Lieu   +14 more
core   +1 more source

Serum peptide biomarkers by MALDI-TOF MS coupled with machine learning for diagnosis and classification of hepato-pancreato-biliary cancers

Scientific Reports
This study aimed to investigate the potential of peptide mass fingerprints (PMFs) of the serum peptidome using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), in combination with machine learning algorithms ...
Piya Prajumwongs, Attapol Titapun, Vasin Thanasukarn, Apiwat Jareanrat, Natcha Khuntikeo, Krit Rattanarak, Nisana Namwat, Poramate Klanrit, Arporn Wangwiwatsin, Jarin Chindaprasirt, Supinda Koonmee, Prakasit Sa-Ngiamwibool, Nattha Muangritdech, Sawanya Charoenlappanit, Janthima Jaresitthikunchai, Sittiruk Roytrakul, Watcharin Loilome   +16 more
doaj   +1 more source

The CXCL5/CXCR2 Axis Attenuates Ferroptosis in Intrahepatic Cholangiocarcinoma Through the Positive Feedback Loop Between PTGS2 Transcriptional Activation and Neutrophil Recruitment

Advanced Science, EarlyView.
The CXCL5/CXCR2 axis directly inhibits ferroptosis in ICC cells by activating the NF‐κB/PTGS2 pathway. Meanwhile, the CXCL5/CXCR2 axis recruits N2 TANs, and the activated PTGS2 promotes the secretion of TNF‐α from the recruited N2 TANs via the CCL2/CCL7/CCR2 pathway, thereby activating the NF‐κB/PTGS2 axis and forming a positive feedback loop, which ...
Chanqi Ye, Kefeng Lin, Shuyao Yang, Yan Zhang, Wenli Gao, Jiaqi Chen, Ying Dong, Rui Bai, Yang Tian, Minghao Wang, Zhijun Yuan, Yuxiao Ma, Yuqin He, Ruyin Chen, Wenguang Fu, Qi Jiang, Qiong Li, Jian Ruan   +17 more
wiley   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Cholangiocarcinoma [PDF]

, 1988
Exploratory laparotomy is frequently used to diagnose, treat, or palliate cholangiocarcinoma although surgery is rarely curative. In light of newly developed percutaneous and endoscopic approaches to diagnosis and therapy, we reviewed our experience with
Cho, Kyung J., Wilson, Joanne A. P., Lynn, Richard B.   +2 more
core   +1 more source

Identifying a unique chromosomal pattern to predict the gemcitabine response in patients with cholangiocarcinoma

Scientific Reports
Cholangiocarcinoma (CCA) is an epithelial bile duct cancer frequently found at an advanced stage, leading to poor response to current therapies. Although gemcitabine (GEM) and cisplatin (CIS) are the current gold-standard for treating unresectable CCA ...
Sutheemon Techa-ay, Sasithorn Watcharadetwittaya, Raksawan Deenonpoe, Prakasit Sa-ngiamwibool, Chanita Panwoon, Watcharin Loilome, Poramate Klanrit, Anchalee Techasen, Yaovalux Chamgramol, Manida Suksawat, Napat Armartmuntree, Thomas O’Connor, Hideyuki Saya, Malinee Thanee   +13 more
doaj   +1 more source

Performance of Mini Parasep® SF stool concentrator kit, Kato-Katz, and formalin-ethyl acetate concentration methods for diagnosis of opisthorchiasis in Northeast Thailand

Parasites & Vectors, 2022
Background Control and elimination of the liver fluke (Opisthorchis viverrini) is a primary preventive strategy against cholangiocarcinoma in Southeast Asia.
Kulthida Y. Kopolrat, Seri Singthong, Narong Khuntikeo, Watcharin Loilome, Chanika Worasith, Chutima Homwong, Chompunoot Wangboon, Patiwat Yasaka, Chatanun Eamudomkarn, Opal Pitaksakulrat, Krisnakorn Tonkhamhak, Arunee Paeyo, Thomas Crellen, Jiraporn Sithithaworn, Paiboon Sithithaworn   +14 more
doaj   +1 more source

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Unveiling the Anticancer Potential and Molecular Mechanisms of Fangchinoline Against Cholangiocarcinoma Using FTIR Microspectroscopy, In Vitro and In Silico Approaches

Integrative Cancer Therapies
Objectives: The limited effectiveness of traditional chemotherapeutic agents against cholangiocarcinoma (CCA) highlights the need for novel compounds.
Piman Pocasap, Karnchanok Kaimuangpak, Krittaya Phukmee, Auemduan Prawan, Sarinya Kongpetch, Laddawan Senggunprai   +5 more
doaj   +1 more source