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Primary sclerosing cholangitis
The American Journal of Surgery, 1987Primary sclerosing cholangitis was seen in only 7 of 6,494 biliary operations performed between 1948 and 1979. Fifteen more cases were seen in 1,467 biliary operations performed over a recent 5 year period. Surgery was directed primarily towards the differential diagnosis between cholangiocarcinoma and primary sclerosing cholangitis of the upper bile ...
T T, White, M J, Hart
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Primary sclerosing cholangitis
The American Journal of Surgery, 1971Abstract Primary sclerosing cholangitis is an uncommon condition of unknown etiology, presenting extrahepatic biliary obstruction due to a chronic inflammatory obliterative process. Criteria for diagnosis include progressive biliary obstruction due to a chronic inflammatory fibrous process, absence of biliary stones, absence of biliary surgery prior ...
A W, Perry +3 more
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Primary Sclerosing Cholangitis
Endoscopy, 1985Primary sclerosing cholangitis was diagnosed in 6 patients (4 men and 2 women), with ages ranging from 33 to 71 years. Four of them had ulcerative colitis, with an evolution from 8 to 21 years, the other two had Crohn's disease with 2 and 3 years of evolution.
A D, Jorge, C, Esley
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Primary sclerosing cholangitis
Current Treatment Options in Gastroenterology, 2001There is no proven medical therapy for primary sclerosing cholangitis. The goal of management should be treatment of symptoms and complications of cholestasis, as well as attempts at treating the underlying disease process. In addition, efforts should be made to recognize and treat or prevent the known complications of primary sclerosing cholangitis ...
Young-Mee, Lee, David J., Kim
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Primary sclerosing cholangitis
Gastroenterology Nursing, 2007Primary sclerosing cholangitis is a chronic cholestatic liver disease of unknown origin characterized by progressive inflammation, destruction, and fibrosis of the intrahepatic and extrahepatic bile ducts. The disease leads to obliteration of intrahepatic bile ducts and to biliary cirrhosis, end-stage liver disease, and portal hypertension.
A.J. SMALL, N.F. LARUSSO, K.N. LAZARIDIS
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Primary Sclerosing Cholangitis
Inflammatory Bowel Diseases, 2005Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the intra- and extrahepatic bile ducts. An estimated 80% of patients in North America and Europe have coexistent inflammatory bowel disease (IBD). The underlying pathophysiology of PSC remains poorly understood.
Jayant A, Talwalkar, Keith D, Lindor
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Primary sclerosing cholangitis
Nature Reviews Disease PrimersPrimary sclerosing cholangitis (PSC) is a chronic biliary inflammation associated with periductular fibrosis of the intrahepatic and extrahepatic bile ducts leading to strictures, bacterial cholangitis, decompensated liver disease and need for liver transplantation.
Michael P. Manns +8 more
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Primary sclerosing cholangitis
Current Problems in Surgery, 1992Primary sclerosing cholangitis is a condition of unknown cause. It is recognized by liver dysfunction and its characteristic radiologic appearance, which is related to portal tract inflammation, bile duct proliferation, and periductal fibroses involving small intrahepatic and large extrahepatic ducts.
F M, Martin, J W, Braasch
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Primary sclerosing cholangitis
The Lancet, 2018Primary sclerosing cholangitis is a rare, chronic cholestatic liver disease characterised by intrahepatic or extrahepatic stricturing, or both, with bile duct fibrosis. Inflammation and fibrosis of bile ducts and the liver are followed by impaired bile formation or flow and progressive liver dysfunction.
Dyson JK +4 more
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Primary Sclerosing Cholangitis
Archives of Internal Medicine, 1982Recent investigations have clarified the clinical, radiologic, and pathologic features of primary sclerosing cholangitis, a chronic fibrosing disorder affecting the biliary tree. This progressive, cholestatic biliary disease is diagnosed when an elevated serum alkaline phosphatase level and stricturing and beading of bile ducts on cholangiography are ...
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