Results 11 to 20 of about 18,704 (213)

Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome [PDF]

Archives of Medical Science, 2022
Introduction Cholecystokinin (CCK) is involved in several metabolic pathways, and CCK agonists are considered as a potential novel treatment option in populations with increased metabolic risk, including polycystic ovary syndrome (PCOS).
Eva Drnovsek, Mojca Jensterle, Katja Goričar, Sara Redenšek, Andrej Janež, Irina Milisav, Vita Dolžan   +6 more
doaj   +2 more sources

Localization of the murine cholecystokinin A and B receptor genes [PDF]

Mammalian Genome, 1995
We have determined the chromosomal locations of the two cholecystokinin (CCK) receptor genes in the mouse. Genetic localization utilized an interspecific backcross panel formed from the cross (C57BL/6J x Mus spretus) F1 x Mus spretus. Genomic DNAs from 94 individuals in the backcross were analyzed by Southern hybridization with rat CCKA and CCKB ...
Isakoff, M. S., Lacourse, K. A., Samuelson, Linda C.   +2 more
openaire   +5 more sources

Corrigendum to “Single-chain fragment variable antibody targeting cholecystokinin-B receptor for pain reduction” [Neurobiol. Pain 10 (2021) 100067] [PDF]

Neurobiology of Pain, 2023
K.N. Westlund, M.A. Montera, A.E. Goins, S.R.A. Alles, M. Afaghpour-Becklund, R. Bartel, R. Durvasula, A. Kunamneni   +7 more
doaj   +2 more sources

Effects of Proglumide with Chemotherapy on the Pancreatic Tumor Microenvironment: Phase 1 PROGEM Trial [PDF]

Pharmaceutics
Background: The primary aim of this Phase 1 clinical trial was to study the safety and dose of a cholecystokinin receptor antagonist, proglumide, in combination with gemcitabine/nab-paclitaxel (GEM-NAB-P) in patients with metastatic pancreatic cancer ...
Jill P. Smith, Gakiza C. Nkulikiyimana, Hong Cao, Wenqiang Chen, Bhaskar Kallakury, John Kwagyan, Anju Duttargi, Benjamin A. Weinberg   +7 more
doaj   +2 more sources

CCK1R2R-/- ameliorates myocardial damage caused by unpredictable stress via altering fatty acid metabolism

Stress, 2023
The heart is the main organ of the circulatory system and requires fatty acids to maintain its activity. Stress is a contributor to aggravating cardiovascular diseases and even death, and exacerbates the abnormal lipid metabolism.
Zhi-Hua Zhang, Chen-Teng Yang, Xiao-Rui Su, Ya-Ping Li, Xiao-Jing Zhang, Song-Jun Wang, Bin Cong   +6 more
doaj   +1 more source

Introduction of a SiFA Moiety into the D-Glutamate Chain of DOTA-PP-F11N Results in Radiohybrid-Based CCK-2R-Targeted Compounds with Improved Pharmacokinetics In Vivo

Pharmaceuticals, 2022
In order to enable 18F- and 177Lu-labelling within the same molecule, we introduced a silicon-based fluoride acceptor (SiFA) into the hexa-D-glutamate chain of DOTA-PP-F11N.
Nadine Holzleitner, Thomas Günther, Roswitha Beck, Constantin Lapa, Hans-Jürgen Wester   +4 more
doaj   +1 more source

Development of the First ¹⁸F-Labeled Radiohybrid-Based Minigastrin Derivative with High Target Affinity and Tumor Accumulation by Substitution of the Chelating Moiety

Pharmaceutics, 2023
In order to optimize elevated kidney retention of previously reported minigastrin derivatives, we substituted (R)-DOTAGA by DOTA in (R)-DOTAGA-rhCCK-16/-18.
Thomas Günther, Nadine Holzleitner, Daniel Di Carlo, Nicole Urtz-Urban, Constantin Lapa, Hans-Jürgen Wester   +5 more
doaj   +1 more source

Investigation of the structure-activity relationship at the N-terminal part of minigastrin analogs

EJNMMI Research, 2023
Background Over the last years, several strategies have been reported to improve the metabolic stability of minigastrin analogs. However, currently applied compounds still reveal limited in vitro and in vivo stability. We thus performed a glycine scan at
Nadine Holzleitner, Thomas Günther, Amira Daoud-Gadieh, Constantin Lapa, Hans-Jürgen Wester   +4 more
doaj   +1 more source

Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages

Acta Pharmaceutica Sinica B, 2023
Myocardial dysfunction is the most serious complication of sepsis. Sepsis-induced myocardial dysfunction (SMD) is often associated with gastrointestinal dysfunction, but its pathophysiological significance remains unclear.
Dandong Fang, Yu Li, Bo He, Daqian Gu, Mingming Zhang, Jingwen Guo, Hongmei Ren, Xinyue Li, Ziyue Zhang, Ming Tang, Xingbing Li, Donghai Yang, Chunmei Xu, Yijie Hu, Hongyong Wang, Pedro A. Jose, Yu Han, Chunyu Zeng   +17 more
doaj   +1 more source

Evidence for a differential cholecystokinin-B and -A receptor regulation of GABA release in the rat nucleus accumbens mediated via dopaminergic and cholinergic mechanisms [PDF]

, 1996
In the present study we characterized the cholecystokinin receptor regulation of (i) the dopamine D2 agonist binding sites in striatal sections including the nucleus accumbens and (ii) GABA and dopamine release in the central part of the rat nucleus ...
FERRARO, Luca Nicola, LI XM, TANGANELLI, Sergio, RIMONDINI R, BEANI, Lorenzo, UNGERSTEDT U, FUXE K, O'CONNOR WT   +7 more
core   +3 more sources