Results 31 to 40 of about 18,704 (213)

Lipase inhibition attenuates the acute inhibitory effects of oral fat on food intake in healthy subjects [PDF]

, 2003
The lipase inhibitor, orlistat, is used in the treatment of obesity and reduces fat absorption by about 30%. However, the mean weight loss induced by orlistat is less than expected for the degree of fat malabsorption.
O'Donovan, D., Wishart, J., Horowitz, M., Feinle-Bisset, C.   +3 more
core   +2 more sources

Direct identification of the agonist binding site in the human brain cholecystokinin-B receptor [PDF]

, 1999
In investigating the agonist binding site of the human brain cholecystokinin(B) receptor (CCK(B)R), we employed the direct protein chemical approach using a photoreactive tritiated analogue of sulfated cholecystokinin octapeptide, which contains the p ...
ter Laak, A.M., Kuenhe, R., Fahrenholz, F., Anders, J.   +3 more
core   +1 more source

No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder [PDF]

Molecular Psychiatry, 2000
Growing animal data implicate cholecystokinin in the regulation of anxiety, while human clinical research confirms the role of cholecystokinin in the provocation of panic attacks. Antipanic medications suppress the ability of cholecystokinin to induce panic attacks, and may alter the expression of the cholecystokinin gene.
S P, Hamilton, S L, Slager, L, Helleby, G A, Heiman, D F, Klein, S E, Hodge, M M, Weissman, A J, Fyer, J A, Knowles   +8 more
openaire   +2 more sources

Synthesis and SAR of New 5-Phenyl-3-ureido-1,5-benzodiazepines as Cholecystokinin-B Receptor Antagonists [PDF]

, 2016
A series of 5-phenyl-3-ureidobenzodiazepine-2,4-diones was synthesized and evaluated as cholecystokinin-B (CCK-B) receptor antagonists. Structure−activity relationship (SAR) studies revealed the importance of the N-1 substituent for potent and selective ...
Robin A. E. Carr (2499427), Stefano Polinelli (3024690), Maria E. Tranquillini (3024693), Silvia Davalli (1572370), Giovanni Gaviraghi (3024678), Mauro Corsi (232233), Marc Marien (2259388), Anna M. Capelli (2403796), Harry Finch (2457709), Emiliangelo Ratti (2372080), Gabriella Finizia (3024684), Frank T. M. Van Amsterdam (3024672), Aldo Reggiani (3024696), Aldo Feriani (2403787), Giovanni Curotto (3024681), Michele Dal Cin (2252812), David G. Trist (2372059), Giorgio Tarzia (1545460), Paolo Cassarà (3024687), Ornella Curcuruto (1676752), Daniele Donati (1533319), Antonella Ursini (3024675), Giorgio Pentassuglia (2372071), Giovanna Tedesco (2259508)   +23 more
core   +1 more source

Contribution of Histamine to Nociceptive Behaviors Induced by Intrathecally Administered Cholecystokinin-8

Frontiers in Pharmacology, 2020
The involvement of spinal release of histamine in the nociceptive behaviors induced by cholecystokinin-8 (CCK-8) was investigated in mice. Intrathecal (i.t.) injection of CCK-8 elicited the nociceptive behaviors consisting of biting and licking.
Takafumi Hayashi, Chizuko Watanabe, Soh Katsuyama, Yasuyuki Agatsuma, Damiana Scuteri, Giacinto Bagetta, Tsukasa Sakurada, Shinobu Sakurada   +7 more
doaj   +1 more source

Gastrin and Gastric CancerSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Gastric cancer is the third leading cause of cancer-related mortality worldwide. Despite progress in understanding its development, challenges with treatment remain. Gastrin, a peptide hormone, is trophic for normal gastrointestinal epithelium. Gastrin
Jill P. Smith, Sandeep Nadella, Nick Osborne   +2 more
doaj   +1 more source

Safety and Pharmacokinetic Assessment of Oral Proglumide in Those with Hepatic Impairment

Pharmaceutics, 2022
Proglumide is an orally administered cholecystokinin receptor antagonist that was found to improve nonalcoholic steatohepatitis, reverse liver fibrosis, and decrease incidence of hepatocellular carcinoma (HCC) in animal models.
Christine C. Hsu, Sunil Bansal, Hong Cao, Coleman I. Smith, Aiwu Ruth He, Martha D. Gay, Yaoxiang Li, Amrita Cheema, Jill P. Smith   +8 more
doaj   +1 more source

Activation of multiple receptors stimulates extracellular vesicle release from trophoblast cells

Physiological Reports, 2020
Reports of the stimulated release of extracellular vesicles (EVs) are few, and the mechanisms incompletely understood. To our knowledge, the possibility that the activation of any one of the multitudes of G‐protein‐coupled receptors (GPCRs) expressed by ...
Kirk P. Conrad, Kubra M. Tuna, Cathleen T. Mestre, Esha S. Banwatt, Abdel A. Alli   +4 more
doaj   +1 more source

Exosome‐mediated gut–brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives—A narrative review

Animal Models and Experimental Medicine, EarlyView.
The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad, Rakesh Ghosh, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Fayez M. Saleh, Amany I. Almars, S. Renuka Jyothi, Rajashree Panigrahi, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Le récepteur CCK2 dans les cancers : ciblage diagnostique et thérapeutique grâce à la vectorisation de nanoparticules magnétiques [PDF]

, 2012
Le récepteur CCK2 est un récepteur à 7 domaines transmembranaires couplé aux protéines G. D'un point de vue physiologique, le récepteur CCK2 joue un rôle central dans la régulation de la digestion, et agit également au niveau du système nerveux central ...
Sanchez, Claire
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