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Hepato-ocular crosstalk: Bile acids bridging pathogenesis and therapy. [PDF]

iScience
Wang P, Xie J, Xiang F, Xiong S, Li Y, Xia B, Lin L, Peng Q.   +7 more
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The metabolism of cholestanol in primary biliary cirrhosis

Journal of Hepatology, 1996
The concentration of serum cholestanol, a 5 alpha-saturated derivative of cholesterol, is increased in primary biliary cirrhosis proportionally to impaired liver function for unknown reasons. The purpose of this study was to analyze serum cholestanol level and its biliary and fecal elimination, and relate the results to cholesterol absorption and ...
Martti Färkkilä, Helena Gylling, Matti Vuoristo   +2 more
exaly   +3 more sources

Biosynthesis of cholestanol in higher plants

Phytochemistry, 2002
To understand the early steps of C(27) brassinosteroid biosynthesis, metabolic experiments were performed with Arabidopsis thaliana and Nicotiana tabacum seedlings, and with cultured Catharanthus roseus cells. [26, 28-2H(6)]Campestanol, [26-2H(3)]cholesterol, and [26-2H(3)]cholestanol were administered to each plant, and the resulting metabolites were ...
Shozo Fujioka, Suguru Takatsuto
exaly   +3 more sources

Squalene and cholestanol in normal rabbit aorta

Atherosclerosis, 1970
Abstract Squalene and cholestanol were isolated from normal rabbit aortic tissue, identified and quantitatively determined. The concentration of squalene and cholestanol was 4.5 and 7.7 mg respectively, in 100 g of dry, delipidized tissue.
V Stefanovich, G Kajiyama
exaly   +3 more sources

Effects of cholestanol feeding on corneal dystrophy in mice

Lipids and Lipid Metabolism, 1991
A cholestanol-enriched diet administered for 8 months to BALB/c mice produced in 20% two kinds of corneal opacities resembling calcific band keratopathy and Schnyder's crystalline dystrophy in humans. The concentrations of cholestanol in serum, liver and cornea of the corneal opacity bearing mice were 30-40-times higher than those of normal mice.
Yousuke Seyama, Takeshi Kasama, T Kasama
exaly   +3 more sources

Cholestanol Metabolism, Molecular Pathology, and Nutritional Implications

Journal of Medicinal Food, 2003
Cholestanol, not cholesterol, is a minor component in the human body and in foods, but an increase in cholestanol concentration in serum induces a pathological condition named cerebrotendinous xanthomatosis (CTX). In our investigation of this disease for more than 25 years, a procedure for quantification of cholestanol by high-performance liquid ...
Yousuke Seyama
exaly   +3 more sources

Cholestanol Esters of Amino Acids

Bulletin of the Chemical Society of Japan, 1967
Abstract The cholestanol (5α-cholestan-3β-ol) esters of amino acids were synthesized with an interest for their possible biochemical activities. The cholestanol esters of glycine, l-alanine, β-alanine, l-leucine and l-aspartic acid were synthesized by a direct fusion of the two components under the passing of hydrogen chloride through ...
Y, Matsumoto, M, Shirai, M, Minagawa
openaire   +2 more sources

Chromatographic separation of putative precursors of cholestanol

Steroids, 1988
This paper describes convenient syntheses for labeled and unlabeled cholest-5-en-3-one, cholest-4-en-3-one, epicholesterol, cholest-4-en-3 beta-ol, and cholest-4-en-3 alpha-ol. The thin-layer chromatography, high-performance liquid chromatography, and gas-liquid chromatography of these compounds and of cholestanol and epicholestanol are also described.
A K, Batta, G, Salen, S, Shefer
openaire   +2 more sources