Results 51 to 60 of about 981,314 (303)

Ezetimibe Normalizes Dietary Cholesterol-Induced Exacerbation of Liver Injury in Alcohol-Fed Mice

Biomolecules
Interactions between alcohol and nutrition play an important role in the development and progression of alcohol-associated liver disease (ALD). Although dietary cholesterol was shown to exacerbate fatty liver and liver injury in alcohol-fed mice ...
Yanchao Xu, Nan Zhang, Piumi B. Wickramasinghe, Kavya Veera, Preethi Parupalli, Alex Dao, Junyu Liu, Rithika Anand, Lyndsey E. Langley, Sreeja Eadha, Hasan Iqbal, Chen Liu, Fang Bian, Lin Jia   +13 more
doaj   +1 more source

Dietary Protein and Blood Pressure: A Systematic Review [PDF]

, 2010
Background - Elevated blood pressure (BP), which is a major risk factor for cardiovascular disease, is highly prevalent worldwide. Recently, interest has grown in the role of dietary protein in human BP.
Wieke Altorf-van der Kuil, Bakker, S.J.L., Bakker, Stephan J. L., Navis, G., Johanna M Geleijnse, Geleijnse, J.M., Baak, M.A. van, Geleijnse Johanna M., Kuil, W.A. van der, Bakker Stephan J. L., van't Veer, Pieter, Bakker, Stephan J. L.; id_orcid, Marleen A van Baak, Geleijnse, Johanna M., Mariëlle F Engberink, van Baak, M.A., Mariëlle F. Engberink, Engberink, Marielle F., Stephan J L Bakker, Altorf-van der Kuil, Wieke, van Baak Marleen A., Pieter van 't Veer, Brink, Elizabeth J., Wieke Altorf – van der Kuil, Bakker, S.J., van Baak, Marleen A., Johanna M. Geleijnse, Brink Elizabeth J., Veer, P., van 't, Engberink Mariëlle F., Brink, E.J., van 't Veer Pieter, Veer, P. van't, Gerjan Navis, van 't Veer, P., Marleen A. van Baak, Navis, Gerjan, Elizabeth J. Brink, Engberink, M.F., Stephan J. L. Bakker, van der Kuil, W., Navis Gerjan, Altorf-van der Kuil, W., Baak, M.A., van, Elizabeth J Brink, Altorf, W., Altorf – van der Kuil Wieke   +46 more
core   +3 more sources

Effects of Causal Beliefs About Gout on Public Views About Gout Management: A Randomized Experimental Study

Arthritis Care &Research, EarlyView.
Objective Despite well‐described biologic causes, the public views unhealthy lifestyle choices as the primary cause of gout. This study investigated how causal beliefs about gout influence the public's views about its management. Methods In a randomized study, 201 members of the public viewed one of two 2‐minute videos about gout.
Rachel Murdoch, Borislav Mihov, Anne Horne, Keith J. Petrie, Gregory D. Gamble, Lachlan Fleck, Nicola Dalbeth   +6 more
wiley   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Management of Hypercholesterolemia Through Dietary ß-glucans–Insights From a Zebrafish Model

Frontiers in Nutrition, 2022
Consumption of lipid-rich foods can increase the blood cholesterol content. β-glucans have hypocholesterolemic effect. However, subtle changes in their molecular branching can influence bioactivity.
Adnan Hussain Gora, Saima Rehman, Viswanath Kiron, Jorge Dias, Jorge M. O. Fernandes, Pål Asgeir Olsvik, Prabhugouda Siriyappagouder, Ioannis Vatsos, Ulrike Schmid-Staiger, Konstantin Frick, Miguel Cardoso   +10 more
doaj   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Nutritional effects on blood lipid and HDL cholesterol concentrations in two subspecies of African green monkeys (Cercopithecus aethiops).

Journal of Lipid Research, 1981
The African green monkey has previously been found to be a promising model for the study of atherosclerosis. We have compared the plasma and HDL cholesterol response to dietary manipulation in the two subspecies of African green monkeys (vervets and ...
L L Rudel, J A Reynolds, B C Bullock
doaj   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Annexin A2 Is Associated with Dietary Cholesterol-Induced Metabolic Dysregulation and the Progression of Hepatic Fibrosis

Metabolites
Background/Objectives: Dietary cholesterol intake significantly influences liver health, yet the specific molecular mechanisms by which it accelerates fibrogenesis remain incompletely defined.
Jiayang Liu, Ling Ou, Haiyan Tai, Yinghan Chai, Lirong Tan, Jie Lin, Bing Li, Ying Cao, Tingting Zhu   +8 more
doaj   +1 more source