Results 101 to 110 of about 1,208,067 (300)
Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscles⃞
Journal of Lipid Research, 2007 Regulation of cholesterol metabolism in cultured cells and in the liver is dependent on actions of the LDL receptor. However, nonhepatic tissues have multiple pathways of cholesterol uptake.Masayoshi Yokoyama, Toru Seo, Taesik Park, Hiroaki Yagyu, Yunying Hu, Ni Huiping Son, Ayanna S. Augustus, Reeba K. Vikramadithyan, Rajasekhar Ramakrishnan, Leslie K. Pulawa, Robert H. Eckel, Ira J. Goldberg +11 moredoaj +1 more sourceEngineered Transformer Base Editor with Enhanced Editing Efficiency
Advanced Science, EarlyView.A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT
Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu +5 morewiley +1 more sourceA Bivariate Genome-Wide Approach to Metabolic Syndrome STAMPEED Consortium [PDF]
, 2010 OBJECTIVE The metabolic syndrome (MetS) is defined as concomitant disorders of lipid and glucose metabolism, central obesity, and high blood pressure, with an increased risk of type 2 diabetes and cardiovascular disease.O'Reilly, Paul F., David J. Couper, Marjo-Riitta Jarvelin, Mathias, Rasika A., Sun, Y. V., Becker, DM, Zhang, Q., Psaty, Bruce M., Dhananjay Vaidya, Assimes, Themistocles L., Rotter, Jerome I, Cashell Jaquish, Becker, LC, McCarthy, Mark I, Boerwinkle, E., Franceschini, Nora, O'Reilly, P. F., O'Reilly, Paul F, Feitosa, MF, Hartikainen, A.-L., Yanek, L., Knowles, JW, Bruce M. Psaty, Becker, Diane M, Mathias, RA, Lewis C. Becker, Goodarzi, Mark O., Kardia, Sharon LR, Glazer, NL, Themistocles L. Assimes, Kraja, Aldi T, Couper, D. J., Mathias, Rasika A, Couper, DJ, Kardia, SL, Kullo, I. J., Rasika A. Mathias, Province, Michael A., Guo Li, Borecki, IB, Absher, Devin, Borecki, Ingrid B., Chakravarti, A, Iribarren, C., Yanek, Lisa, Kari E. North, Jaquish, Cashell, O’Reilly, Paul F, Sovio, U., Becker, D. M., Sun, Yan V, Kraja, AT, Paul F. O’Reilly, Yii-Der Ida Chen, Lisa Yanek, Vaidya, D., Quertermous, Thomas, Chen, Yii-Der Ida, Leena Palotie, Sun, Yan V., Boerwinkle, Eric, Aldi T. Kraja, Goodarzi, Mark O, Pankow, JS, Talin Haritunians, Psaty, Bruce M, Palotie, L., Boerwinkle, E, Zhang, Q, Becker, L. C., Kral, Brian, Sovio, U, Feitosa, Mary F., Haritunians, T., North, Kari E., Haritunians, Talin, Brian Kral, Quertermous, T., Chen, Y.-d. I., Hartikainen, Anna-Liisa, Feitosa, Mary F, Chakravarti, A., Jarvelin, Marjo-Riitta, Hartikainen, AL, Mark O. Goodarzi, Diane M. Becker, Chakravarti, Aravinda, Sharon L.R. Kardia, Mary F. Feitosa, Palotie, L, Couper, David J., Anna-Liisa Hartikainen, Borecki, I. B., Nora Franceschini, Jarvelin, MR, North, Kari E, Knowles, Joshua W, Pankow, James S, Jerome I. Rotter, Couper, David J, Franceschini, N., McCarthy, M. I., Iribarren, C, Psaty, BM, Yanek, L, Vaidya, Dhananjay, Psaty, B. M., Kral, B, Becker, Lewis C, Kral, B., Michael A. Province, Ingrid B. Borecki, Chen, YD, Goodarzi, M. O., Glazer, N. L., Becker, Lewis C., Palotie, Leena, Jaquish, C., Kraja, Aldi T., Glazer, Nicole L, Kullo, IJ, Thomas Quertermous, Kullo, Iftikhar J, Joshua W. Knowles, Carlos Iribarren, Zhang, Qunyuan, Quertermous, T, Ulla Sovio, Li, Guo, Haritunians, T, Mathias, R. A., Jarvelin, M.-r., Sovio, Ulla, Qunyuan Zhang, Iftikhar J. Kullo, Province, Michael A, Rotter, J. I., Pankow, James S., Province, MA, McCarthy, MI, James S. Pankow, Knowles, J. W., Borecki, Ingrid B, Li, G, Eric Boerwinkle, Becker, Diane M., Kardia, Sharon L. R., Glazer, Nicole L., O'Reilly, PF, Sun, YV, North, K. E., Li, G., Mark I. McCarthy, Absher, D, Iribarren, Carlos, Vaidya, D, Absher, D., Feitosa, M. F., Franceschini, N, Aravinda Chakravarti, Knowles, Joshua W., Assimes, Themistocles L, Yan V. Sun, Kardia, S. L. R., Pankow, J. S., Rotter, Jerome I., Assimes, TL, Devin Absher, McCarthy, Mark I., North, KE, Assimes, T. L., Goodarzi, MO, Province, M. A., Jaquish, C, Nicole L. Glazer, Rotter, JI, Kraja, A. T., Kullo, Iftikhar J. +177 morecore +1 more sourcePlasma Low-Density Lipoprotein Cholesterol Correlates With Heart Function in Individuals With Type 2 Diabetes Mellitus: A Cross-Sectional Study
Frontiers in Endocrinology, 2019 Background: Heart failure is a frequent complication of type 2 diabetes mellitus (T2DM). Plasma cholesterol, particularly the proatherogenic low-density lipoprotein (LDL) cholesterol, impairs heart function by promoting atheroma formation and ventricular Po-Chung Cheng, Shang-Ren Hsu, Jung-Chi Li, Ching-Pei Chen, Szu-Chi Chien, Shih-Te Tu, Yun-Chung Cheng, Yu-Hsiu Liu, Jeng-Fu Kuo +8 moredoaj +1 more sourceProteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets
Advanced Science, EarlyView.An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li +18 morewiley +1 more sourceEffect of apolipoprotein E phenotype on diet-induced lowering of plasma low density lipoprotein cholesterol.
Journal of Lipid Research, 1994 The National Cholesterol Education Program (NCEP) has recommended that dietary total fat, saturated fat, and cholesterol intake be reduced to < or = 30% of calories, < 10% of calories, and < 300 mg/day, respectively (Step 1 diet) in the general ...J Lopez-Miranda, J.M. Ordovas, P Mata, A.H Lichtenstein, B Clevidence, J.T Judd, E.J Schaefer +6 moredoaj +1 more sourceIncorporating a Genetic Risk Score into Coronary Heart Disease Risk Estimates: Effect on LDL Cholesterol Levels (the MIGENES Clinical Trial)
Circulation, 2016 Background Whether knowledge of genetic risk for coronary heart disease (CHD) affects health-related outcomes is unknown. We investigated whether incorporating a genetic risk score (GRS) in CHD risk estimates lowers low-density lipoprotein cholesterol ...I. Kullo, H. Jouni, E. Austin, Sherry-Ann Brown, Teresa M. Kruisselbrink, I. Isseh, Raad A. Haddad, Tariq S. Marroush, K. Shameer, J. Olson, U. Broeckel, R. Green, D. Schaid, V. Montori, K. Bailey +14 moresemanticscholar +1 more source
