Results 101 to 110 of about 297,626 (305)

Genotypes relative to LDL-cholesterol distribution for 6 variants significantly associated with LDL-cholesterol levels after logistic regression. [PDF]

, 2020
The 993 AWI-Gen individuals with low and high LDL-cholesterol are included in the plots. A-D: APOB rs6752026, LDLRAP1 rs12071264, PCSK9 rs45613943 and LDLR rs72658855 show how LDL-cholesterol levels decrease with presence of the minor allele.
Robyn Kerr (8478948), Michèle Ramsay (83973), Mahtaab Hayat (8478945), Charles N. Rotimi (8478951), Frederick J. Raal (8478954), Amy R. Bentley (7634120)   +5 more
core   +1 more source

Quo vadis, LDL cholesterol?

Advances in Laboratory Medicine, 2023
Cobos Andrés, Valdivielso Pedro
doaj   +1 more source

Plasma Low-Density Lipoprotein Cholesterol Correlates With Heart Function in Individuals With Type 2 Diabetes Mellitus: A Cross-Sectional Study

Frontiers in Endocrinology, 2019
Background: Heart failure is a frequent complication of type 2 diabetes mellitus (T2DM). Plasma cholesterol, particularly the proatherogenic low-density lipoprotein (LDL) cholesterol, impairs heart function by promoting atheroma formation and ventricular
Po-Chung Cheng, Shang-Ren Hsu, Jung-Chi Li, Ching-Pei Chen, Szu-Chi Chien, Shih-Te Tu, Yun-Chung Cheng, Yu-Hsiu Liu, Jeng-Fu Kuo   +8 more
doaj   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Rasio Monosit LDL Cholesterol dan Neutrofil LDL Cholesterol pada Penderita TB [PDF]

This study analyzes the relationship between monocyte LDL cholesterol and LDL neutrophil values ​​in patients with pulmonary TB. The research method used is descriptive observational analytic with a cross-sectional study design.
Saquro, Abdan, Muslina, Muslina, Elisma, Elisma, Agraini, Agraini, Lestari, Uce   +4 more
core   +2 more sources

Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importnace of Lp(a) [PDF]

, 2012
We carried out a genome-wide association study (GWAS) of LDL-c response to statin using data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n = 1,156), the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT; n = 895), and the ...
Postmus, Iris, Colhoun, H.M., McKeigue, Paul M, Stanton, A.V., Trompet, S., Hyde, Craig, Colhoun, Helen M, Caulfield, M., Shields, Denis C., Hitman, Graham A, CARDS, Poulter, Neil, Shields, D.C., Sever, P., Chatterjee, Aurobindo, Trompet, Stella, Durrington, Paul N, Deshmukh, H.A., DeMicco, D.A., Calle, Roberto A., Hitman, Graham A., Neil, A., McKeigue, Paul M., Fuller, John H., Postmus, I., Hitman, G.A., DeMicco, David A., Johnson, T., ?, ?, Calle, Roberto A, Betteridge, D.J., Livingstone, Shona, Ford, Ian, McKeigue, P.M., Stanton, Alice V., Jukema, J.W., Johnson, Toby, Durrington, Paul N., Neil, Andrew, PROSPER Investigators, Livingstone, S., Jukema, J. Wouter, ASCOT, Colhoun, Helen, Ford, I., Sever, Peter, Fuller, J.H., Jukema, J Wouter, Caulfield, Mark, Fuller, John H, Chatterjee, A., Deshmukh, Harshal A, Calle, R.A., Hyde, C., Charlton-Menys, V., Poulter, N., Charlton-Menys, Valentine, DeMicco, David A, Betteridge, D John, McKeigue, Paul M.; id_orcid, Betteridge, D. John, Durrington, P.N., Colhoun, Helen M., Shields, Denis C, Deshmukh, Harshal A., Stanton, Alice V   +65 more
core   +1 more source

Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscles⃞

Journal of Lipid Research, 2007
Regulation of cholesterol metabolism in cultured cells and in the liver is dependent on actions of the LDL receptor. However, nonhepatic tissues have multiple pathways of cholesterol uptake.
Masayoshi Yokoyama, Toru Seo, Taesik Park, Hiroaki Yagyu, Yunying Hu, Ni Huiping Son, Ayanna S. Augustus, Reeba K. Vikramadithyan, Rajasekhar Ramakrishnan, Leslie K. Pulawa, Robert H. Eckel, Ira J. Goldberg   +11 more
doaj   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Effect of apolipoprotein E phenotype on diet-induced lowering of plasma low density lipoprotein cholesterol.

Journal of Lipid Research, 1994
The National Cholesterol Education Program (NCEP) has recommended that dietary total fat, saturated fat, and cholesterol intake be reduced to < or = 30% of calories, < 10% of calories, and < 300 mg/day, respectively (Step 1 diet) in the general ...
J Lopez-Miranda, J.M. Ordovas, P Mata, A.H Lichtenstein, B Clevidence, J.T Judd, E.J Schaefer   +6 more
doaj   +1 more source

Mapping Steroidogenic Perturbations Under Endocrine Disruptor Mixtures Across Demographic Subgroups: Structural and Metabolomic Insights

Advanced Science, EarlyView.
Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen, Lei Huang, Yingtong Jiang, Guohong Zhao, Mengyuan Zhu, Xiulian Lu, Lang Lang, Akinpelumi Oluwatobiloba Esther, Longhao Fan, Yuqi Jiang, Chang Sun, Xiaoling Zhang, Kun Zhou, Xiaoming Ji, Minjian Chen   +14 more
wiley   +1 more source