Results 121 to 130 of about 1,208,067 (300)

Association between LDL-cholesterol lowering genetic variants and risk of type 2 diabetes

Journal of the American Medical Association (JAMA), 2016
Importance Low-density lipoprotein (LDL) cholesterol-lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and statins, have previously been used as proxies to study the efficacy of these lipid-lowering drugs.
L. Lotta, S. Sharp, S. Burgess, J. Perry, I. Stewart, Sara M. Willems, J. Luan, E. Ardanaz, L. Arrióla, B. Balkau, H. Boeing, P. Deloukas, N. Forouhi, P. Franks, S. Grioni, R. Kaaks, T. Key, C. Navarro, P. Nilsson, K. Overvad, D. Palli, S. Panico, J. Quirós, E. Riboli, O. Rolandsson, C. Sacerdote, Elena C Salamanca, N. Slimani, A. Spijkerman, A. Tjønneland, R. Tumino, D. van der A, Y. van der Schouw, M. McCarthy, I. Barroso, S. O’Rahilly, D. Savage, N. Sattar, C. Langenberg, R. Scott, N. Wareham   +40 more
semanticscholar   +1 more source

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Complementary therapy to target LDL cholesterol: the role of the ezetimibe/simvastatin combination

, 2006
Ryan C Neal, Peter H JonesBaylor College of Medicine, Section of Lipid and Atherosclerosis, Houston, TX, USAAbstract: Cardiovascular (CV) disease remains the number 1 cause of death in the USA.
Ryan C Neal, Peter H Jones
core  

Regulation of hepatic LDL metabolism in the guinea pig by dietary fat and cholesterol.

Journal of Lipid Research, 1994
Studies were carried out to determine the independent and interactive effects of dietary fat and cholesterol on the regulation of hepatic apoB/E receptor expression and its relationship to hepatic cholesterol concentrations and low density lipoprotein ...
E C Lin, M L Fernandez, M A Tosca, D J McNamara   +3 more
doaj   +1 more source

Association of Serum LDL Cholesterol Level with Periodontitis among Patients Visiting a Tertiary-care Hospital

Journal of Nepal Medical Association, 2011
Introduction: High low-density lipoproteins (LDL) cholesterol is one of the major risk factors for cardiovascular disease. In recent years, some evidence has been presented that periodontitis,an infectious inflammatory condition of the periodontium, is ...
S Sharma, M Lamsal, SK Sharma, SR Niraula, B Koirala   +4 more
doaj   +1 more source

Stabilization of PUFA‐Rich Mayonnaise Against Lipid Oxidation: A Review of the Last Three Decades of Research

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Mayonnaise, a widely consumed oil‐in‐water emulsion, is highly susceptible to lipid oxidation due to its high content of polyunsaturated fatty acids (PUFAs) and the presence of pro‐oxidant factors such as low pH and iron from egg yolk. Over the past three decades, extensive research has focused on understanding oxidation mechanisms, analytical
Sakhi Ghelichi, Betül Yesiltas, Charlotte Jacobsen   +2 more
wiley   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Oat beta-glucan lowers total and LDL-cholesterol

, 2001
Several soluble polysaccharides have been shown to have cholesterol-lowering properties and to have a role in prevention of heart disease. Major sources of one such polysaccharide (beta-glucan) are oats and barley.
P Nestel (13299699), R Tupper (13746508), Sylvia Pomeroy (13050252), M Cehun-Aders (13746511)   +3 more
core  

Rasio Monosit LDL Cholesterol dan Neutrofil LDL Cholesterol pada Penderita TB [PDF]

This study analyzes the relationship between monocyte LDL cholesterol and LDL neutrophil values ​​in patients with pulmonary TB. The research method used is descriptive observational analytic with a cross-sectional study design.
Saquro, Abdan, Muslina, Muslina, Elisma, Elisma, Agraini, Agraini, Lestari, Uce   +4 more
core   +1 more source