Results 231 to 240 of about 297,274 (306)

Melatonin Promotes Improvement in Serum Lipid Levels and Liver Histopathology in Hyperlipidemic Rats

Lipids, EarlyView.
ABSTRACT Hyperlipidemia or dyslipidemia is the term used for the increase in lipid levels in blood plasma, usually occurring due to a high‐fat diet associated with a sedentary lifestyle. The increase in lipid levels can cause fatty infiltration in the liver known as hepatic steatosis, which can lead to inflammation, fibrosis, and necrosis consecutively.
Ana Cláudia Carvalho de Sousa, Jaiurte Gomes Martins da Silva, Érique Ricardo Alves, Laís Caroline da Silva Santos, Bruno José do Nascimento, Marcelle Mariana Sales de França, Vanessa Bischoff Medina, Ismaela Maria Ferreira de Melo, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley Teixeira   +9 more
wiley   +1 more source

Ketogenic Diets and Low-Density Lipoprotein Cholesterol in Adults With Normal Weight: An Emerging Clinical Challenge. [PDF]

J Am Heart Assoc
DiMattia ZS, Petersen KS.
europepmc   +1 more source

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source

Effects of inclisiran therapy on metabolomic and lipoproteomic profiles in dyslipidemic patients. [PDF]

Front Pharmacol
Patrussi J, Vignoli A, Tenori L, Sorrentino A, Berteotti M, Lotti E, Crudele F, Ciarrocca Taranta G, Rogolino AA, Barbieri G, Gori AM, Marcucci R.   +11 more
europepmc   +1 more source

Unraveling the Shared Genetic Architecture and Molecular Mechanisms Linking Cardiovascular Traits and Glaucoma: A Comprehensive Cross‐Trait Analysis

Medicine Advances, EarlyView.
This study investigates the shared genetic architecture between eight cardiovascular traits and glaucoma using comprehensive cross‐trait analysis. We identified 9948 pleiotropic loci, 71 colocalized signals, and 24 shared genes, with BCAS3, BICC1, FAM213A, ITGB5, NUP160, and TNS1 emerging as robust cross‐trait candidates.
Junfei Huang, Zejun Chen, Mengqing Lin, Bingyu Xu, Qiang Liu, Zhengran Li, Jianping Gao, Guoguo Yi, Min Fu   +8 more
wiley   +1 more source

The Molecular Mechanisms of Metformin's Action on Blood Lipid Profile in Diabetic Patients. [PDF]

Int J Mol Sci
Dettlaff-Pokora A, Swierczynski J.
europepmc   +1 more source

Effectiveness and Safety of Setmelanotide in a Patient With a Heterozygous PCSK1 Deficiency

Obesity, EarlyView.
ABSTRACT Setmelanotide, a melanocortin 4 receptor (MC4R) agonist, is a promising pharmacological treatment option for people with rare monogenic obesity conditions affecting the leptin‐melanocortin signaling pathway, including proprotein convertase subtilisin/kexin type 1 (PCSK1) gene mutations.
Ellina Lytvyak, Arshdeep Rattol, Eduardo Grunvald   +2 more
wiley   +1 more source

Lipid and High-Density Lipoprotein (HDL) Subfraction Changes in Premenopausal and Postmenopausal Women With Breast Cancer Receiving Hormonal Therapy. [PDF]

Cureus
Nikolakopoulou A, Nastos K, Papakonstantinou D, Stavrati KE, Michalaki V, Koutroulis G, Dafnios N, Papakonstantinou I, Papadimitriou C.   +8 more
europepmc   +1 more source

Musculoskeletal Outcomes of Glucagon‐Like Peptide‐1 Receptor Agonists Versus Other Antiobesity Agents in Nondiabetic Adults

Obesity, EarlyView.
ABSTRACT Objective This study aimed to evaluate the association of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) with risks of osteoporosis, major osteoporotic fractures, and degenerative musculoskeletal disorders in nondiabetic adults with obesity compared with other obesity medications.
Jie‐Syuan Wu, Lee‐Yuan Lin, Jia‐Wei Sun, Wei‐Ting Yu, Fara Silvia Yuliani, Shyh‐Hsiang Lin   +5 more
wiley   +1 more source

Six‐ and Twelve‐Month Changes in Body Composition and 24‐h Energy Expenditure After a Very Low‐Calorie Ketogenic Diet

Obesity, EarlyView.
ABSTRACT Objective This study assessed changes in body composition and 24‐h energy metabolism at 6 and 12 months after initiation of a 1‐month very low‐calorie ketogenic diet (VLCKD) in women with obesity. Methods Seventeen women with obesity who completed a 1‐month VLCKD underwent a 4‐week transition phase with carbohydrate reintroduction, followed by
Alessio Basolo, Paolo Piaggi, Valentina Angeli, Paola Fierabracci, Chiara Bologna, Giordano Paolucci, Guido Salvetti, Luca Chiovato, Jonathan Krakoff, Alberto Landi, Ferruccio Santini   +10 more
wiley   +1 more source