Results 61 to 70 of about 381,129 (289)

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology

Angewandte Chemie, EarlyView.
Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker, Adrian Pui Ting Ho, Laura S. Itzhaki, Ljiljana Fruk   +3 more
wiley   +2 more sources

Differences in the metabolism of oxidatively modified low density lipoprotein and acetylated low density lipoprotein by human endothelial cells: inhibition of cholesterol esterification by oxidatively modified low density lipoprotein.

Journal of Lipid Research, 1989
The rate of degradation of oxidatively modified low density lipoprotein (Ox-LDL) by human endothelial cells was similar to that of unmodified low density lipoprotein (LDL), and was approximately 2-fold greater than the rate of degradation of acetylated ...
I Jialal, A Chait
doaj  

Effect of diet, statin, and ômega-3 fatty acids on the blood pressure and lipidemia in humans [PDF]

, 2009
As doenças cardiovasculares são responsáveis pela alta taxa de mortalidade nos países desenvolvidos e em desenvolvimento, assim, têm sido alvo de vários estudos.
DENARDI, Daniela Cristiane Ferrari, MOREIRA, Renê, SALGADO, Jocelem Mastrodi   +2 more
core   +2 more sources

Lactate‐Activated GPR132‐Src Signal Induces Macrophage Senescence and Aggravates Atherosclerosis Under Diabetes

Advanced Science, EarlyView.
Elevated lactate in diabetes activates the GPR132‐Src pathway in macrophages, inducing macrophage senescence and further enhancing foam cell formation. This mechanism exacerbates atherosclerotic progression. Abstract Diabetes is widely acknowledged as a significant risk factor for atherosclerosis, facilitating plaque formation through various ...
Xiaofeng Ge, Shuying Wang, Zhaokai Li, Jing Yu, Binbin Liu, Ruiying Wang, Shichen Bu, Nawsher wan, Yan Wang, Cuilian Dai, Yijun Lin   +10 more
wiley   +1 more source

Cholesterol delivered to macrophages by oxidized low density lipoprotein is sequestered in lysosomes and fails to efflux normally

Journal of Lipid Research, 2000
Oxidized low density lipoprotein (LDL) has been found to exhibit numerous potentially atherogenic properties, including transformation of macrophages to foam cells.
Baljinder S. Dhaliwal, Urs P. Steinbrecher   +1 more
doaj  

Replication of LDL SWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses [PDF]

, 2011
<p><b>Background:</b> The PHArmacogenetic study of Statins in the Elderly at risk (PHASE) is a genome wide association study in the PROspective Study of Pravastatin in the Elderly at risk for vascular disease (PROSPER) that investigates
Anton JM de Craen, Brendan M Buckley, C Wallace, CJ Willer, David J Stott, DB Goldstein, DM Waterworth, FM Sacks, Frank Sacks, Ian Ford, Iris Postmus, J Shepherd, J Shepherd, J Shepherd, J Wouter Jukema, JA Johnson, James J Devlin, KJ Kalantzi, L Ma, MJ Barber, MS Sandhu, Muriel Caslake, Naveed Sattar, P Eline Slagboom, PG McGovern, RA Kreisberg, Rudi GJ Westendorp, S Kathiresan, S Kathiresan, Stella Trompet, TM Teslovich, YS Aulchenko   +31 more
core   +4 more sources

LDL cholesterol: How low to go? [PDF]

Trends in Cardiovascular Medicine, 2018
Epidemiology and the results of large-scale outcome trials indicate that the association of LDL with atherosclerotic cardiovascular disease is causal, and continuous not only across levels seen in the general population but also down to sub-physiological values.
openaire   +3 more sources

Wogonin Attenuates Atherosclerosis via KLF11‐Mediated Suppression of PPARα‐YAP1‐Driven Glycolysis and Enhancement of ABCA1/G1‐Mediated Cholesterol Efflux

Advanced Science, EarlyView.
PPARα promotes KLF11 expression and recruits KLF11 and YAP1 to form a transcription complex, where KLF11 acts as a brake in PPARα‐YAP1‐mediated glycolysis. Wogonin reshapes the metabolism of macrophages from glycolysis to fatty acid oxidation via activation of the PPARα‐KLF11‐YAP1 pathway, by which wogonin reduces inflammation and foam cell formation ...
Chuanrui Ma, Yunqing Hua, Shu Yang, Yun Zhao, Wei Zhang, Yaodong Miao, Jing Zhang, Boxuan Feng, Guobin Zheng, Lan Li, Zhihao Liu, Han Zhang, Mingjun Zhu, Xiumei Gao, Guanwei Fan   +14 more
wiley   +1 more source

LDL particle size and LDL and HDL cholesterol changes with dietary fat and cholesterol in healthy subjects

Journal of Lipid Research, 1998
We have conducted a dietary trial in 54 men and 51 women with a wide range of fasting cholesterol values to examine the use of low density lipoprotein (LDL) particle size to predict the lipoprotein response to dietary fat and cholesterol.
Peter M. Clifton, Manny Noakes, Paul J. Nestel   +2 more
doaj