Results 41 to 50 of about 297,626 (305)

Cardiovascular outcomes and LDL-cholesterol levels in EMPA-REG OUTCOME

Diabetes & Vascular Disease Research, 2020
Objective: It is well established that higher low-density lipoprotein (LDL)-cholesterol levels are associated with increased cardiovascular risk. We analyzed whether effects of empagliflozin on cardiovascular outcomes varied by different LDL-cholesterol ...
Gisle Langslet, Bernard Zinman, Christoph Wanner, Stefan Hantel, Rosa-Maria Espadero, David Fitchett, Odd Erik Johansen   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Effects of inhibiting cholesterol absorption and synthesis on cholesterol and lipoprotein metabolism in hypercholesterolemic non-insulin-dependent diabetic men.

Journal of Lipid Research, 1996
Effectiveness of a simultaneous inhibition of cholesterol absorption and synthesis, caused by sitostanol ester margarine and pravastatin, was studied to control mild hypercholesterolemia in men with non-insulin-dependent diabetes mellitus (NIDDM) (n = 8).
H Gylling, T A Miettinen
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines [PDF]

, 2006
Objective - Although inflammation is a recognized feature of atherosclerosis, the impact of inflammation on cellular cholesterol homeostasis is unclear.
Moorhead, JF, Wheeler, DC, Ruan, XZ, Varghese, Z, Ma, KL, Tao, JL, Powis, SH   +6 more
core  

Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function [PDF]

, 2011
Cholesterol regulates plasma membrane (PM) association and functioning of syntaxin-4 and soluble N-ethylmaleimide-sensitive fusion protein 23 (SNAP23) in the secretory pathway.
Enrich Bastús, Carles, Tebar Ramon, Francesc, Reverter Martín, Meritxell, Rentero Alfonso, Carles, Meritxell Reverter, Mulay, Vishwaroop, Peta Wood, Vilà de Muga, Sandra, Álvarez-Guaita, Anna, Anna Alvarez-Guaita, Albert Pol, Francesc Tebar, Carlos Enrich, Cairns, Rose, Joan Blasi, Blasi Cabús, Joan, Carles Rentero, Vishwaroop Mulay, Rose Cairns, Wood, Peta, Katia Monastyrskaya, Grewal, Thomas, Pol i Sorolla, Albert, Thomas Grewal, Monastyrskaya, Katia, Sandra Vilà de Muga   +25 more
core   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Genetic Variation in FADS Genes and Plasma Cholesterol Levels in 2-Year-Old Infants [PDF]

, 2013
Single nucleotide polymorphisms (SNPs) in genes involved in fatty acid metabolism (FADS1 FADS2 gene cluster) are associated with plasma lipid levels. We aimed to investigate whether these associations are already present early in life and compare the ...
Moltó-Puigmartí Carolina, Penders, J., Ronald P Mensink, Carolina Moltó-Puigmartí (5261441), Jogchum Plat (302633), Thijs Carel, Monique Mommers, Thijs, Carel, Mommers, Monique, Eugène Jansen, Dirkje S Postma, Mensink Ronald P., John Penders (396322), Mommers Monique, Plat, J., Mensink, Ronald P., Koppelman, Gerard H., Standl Marie, Dirkje S. Postma (101740), Joachim Heinrich (60421), Postma, D.S., Jansen, Eugène, Standl, Marie, Moltó-Puigmartí, Carolina, Penders John, Koppelman Gerard H., Heinrich Joachim, Mensink, R.P., Thijs, C., Gerard H. Koppelman (153163), Postma, Dirkje S., Moltó-Puigmarti, C., Plat Jogchum, Carolina Moltó-Puigmartí, Carel Thijs (112720), Postma Dirkje S., Jansen, E., Joachim Heinrich, Marie Standl, Carel Thijs, Heinrich, Joachim, Jogchum Plat, Mommers, M., Standl, M., Monique Mommers (112709), Heinrich, J., Ronald P. Mensink (302629), Koppelman, Gerard H.; id_orcid, John Penders, Eugène Jansen (123572), Marie Standl (163136), Thijs, C.; id_orcid, Plat, Jogchum, Penders, John, Gerard H Koppelman, Koppelman, G.H., Jansen Eugène   +56 more
core   +1 more source

Quantitation of the in vitro free cholesterol exchange of human red cells and lipoproteins

Journal of Lipid Research, 1970
The exchange of free cholesterol in vitro between human red blood cells and low density lipoproteins (LDL) was quantified. The flux of sterol between LDL and red cells was relatively constant over a wide range of concentrations of free cholesterol in ...
STEVEN H. QUARFORDT, HELEN L. HILDERMAN
doaj   +1 more source