Results 111 to 120 of about 1,863,899 (386)

Retrospective on Cholesterol Homeostasis: The Central Role of Scap.

Annual Review of Biochemistry, 2018
Scap is a polytopic membrane protein that functions as a molecular machine to control the cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory discovered Scap, we have learned how it binds sterol regulatory element ...
Michael S. Brown, A. Radhakrishnan, J. Goldstein   +2 more
semanticscholar   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Biliary cholesterol crystallization characterized by single-crystal cryogenic electron diffraction

Journal of Lipid Research, 2005
Cholesterol crystals are the building blocks of cholesterol gallstones. The exact structure of early-forming crystals is still controversial. We combined cryogenic-temperature transmission electron microscopy with cryogenic-temperature electron ...
Daphne Weihs, Judith Schmidt, Ilana Goldiner, Dganit Danino, Moshe Rubin, Yeshayahu Talmon, Fred M. Konikoff   +6 more
doaj  

Low Lipid Levels and High Variability are Associated With the Risk of New‐Onset Atrial Fibrillation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background While high levels of lipids and lipid variability are established risk factors for atherosclerotic cardiovascular disease, their roles in the development of atrial fibrillation (AF) are unclear, with previous studies suggesting a “cholesterol ...
Hyun‐Jung Lee, So‐Ryoung Lee, Eue‐Keun Choi, Kyung‐Do Han, Seil Oh   +4 more
doaj   +1 more source

Cholesterol and the risk of grade-specific prostate cancer incidence: evidence from two large prospective cohort studies with up to 37 years' follow up [PDF]

, 2012
<b>Background</b> High cholesterol may be a modifiable risk factor for prostate cancer but results have been inconsistent and subject to potential "reverse causality" where undetected disease modifies cholesterol prior to diagnosis.<p ...
A Jemal, AG Renehan, AM Mondul, AM Mondul, Carole Hart, CL Hart, CL Hart, DA Lawlor, David S Morrison, DM Boudreau, DR Browning, E Giovannucci, EA Platz, EA Platz, EL Korn, F Bravi, F Bray, G Davey Smith, G Davey Smith, GD Batty, General Register Office, Hing Leung, HM Van, HY Oh, J Green, JD Kark, JD Neaton, Kashif Shafique, Khaver Qureshi, KM Dale, L Zhuang, L Zuccolo, LE Johns, LJ Schouten, MH Hager, MJ Resnick, ML Turley, MM Thompson, MR Freeman, National Heart, Lung and Blood Institute, P Knekt, PD Baade, Philip McLoone, RA Hiatt, RM White, TE Strandberg, VM Hawthorne, WA Sakr, Y Ben-Shlomo   +48 more
core   +2 more sources

Glycosylation Gene Signatures as Prognostic Biomarkers in Glioblastoma

Annals of Clinical and Translational Neurology, Volume 12, Issue 7, Page 1378-1394, July 2025.
ABSTRACT Objective Glioblastoma (GBM) is an aggressive brain tumor characterized by significant heterogeneity. This study investigates the role of glycosylation‐related genes in GBM subtyping, prognosis, and response to therapy. Methods We analyzed mRNA expression data and clinical information from The Cancer Genome Atlas (TCGA) and Gene Expression ...
Tong Zhao, Hongliang Ge, Chenchao Lin, Xiyue Wu, Jianwu Chen   +4 more
wiley   +1 more source

ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signaling in Niemann-Pick type C

Nature Cell Biology, 2019
Cholesterol activates the master growth regulator, mTORC1 kinase, by promoting its recruitment to the surface of lysosomes by the Rag guanosine triphosphatases (GTPases).
Chun-Yan Lim, Oliver B. Davis, Hijai R. Shin, Justin Zhang, Charles A. Berdan, Xuntian Jiang, Jessica L. Counihan, D. Ory, Daniel K. Nomura, R. Zoncu   +9 more
semanticscholar   +1 more source

The Impact of Diabetes and Metabolic Syndrome Burden on Pain, Neuropathy Severity and Fiber Type

Annals of Clinical and Translational Neurology, Volume 12, Issue 7, Page 1408-1417, July 2025.
ABSTRACT Objective Determine the association between diabetes and metabolic syndrome (MetS) burden (number of MetS criteria fulfilled) and pain, neuropathy severity, and fiber type involvement in individuals with established polyneuropathy. Methods The Peripheral Neuropathy Research Registry was queried for individuals with type 1 and type 2 diabetes ...
Long Davalos, Brian C. Callaghan, Lavanya Muthukumar, Simone Thomas, Evan L. Reynolds, A. Gordon Smith, J. Robinson Singleton, Ahmet Höke, Senda Ajroud‐Driss, Mazen M. Dimachkie, Stefanie Geisler, David M. Simpson, PNRR Study Group, Amro M. Stino   +13 more
wiley   +1 more source

Effects of dalcetrapib in patients with a recent acute coronary syndrome [PDF]

, 2012
In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events.
Abt, Markus, Ballantyne, Christie M., Barter, Philip J., Brumm, Jochen, Chaitman, Bernard R., Colquhoun, David, Holme, Ingar M., Kallend, David, Leiter, Lawrence A., Leitersdorf, Eran, McMurray, John J. V., Mundl, Hardi, Nicholls, Stephen J., Olsson, Anders G., Schwartz, Gregory G., Shah, Prediman K., Tardif, Jean-Claude, The dal-OUTCOMES Investigators, Wright, R. Scott   +18 more
core   +2 more sources

Serotonergic and Dopaminergic Function in Neuropsychiatrically Asymptomatic People With HIV on Antiretroviral Therapy

Annals of Clinical and Translational Neurology, Volume 12, Issue 7, Page 1418-1430, July 2025.
ABSTRACT Objective People with HIV (PWH) on antiretroviral therapy (ART) still experience neurocognitive dysfunction and accelerated brain volume loss. To assess whether the serotonergic and dopaminergic systems are affected, we used [11C]DASB positron emission tomography (PET) to assess presynaptic serotonergic function and [18F]FDOPA PET to measure ...
Chuen‐Yen Lau, Anna Lyndaker, Swati Shah, Paul Wakim, Amelia Mitchell, Cynthia Monroe, Alan Kim, Tracy L. Cropper, Govind Nair, Joseph Snow, Bryan R. Smith, Avindra Nath, Dima A. Hammoud   +12 more
wiley   +1 more source