Results 191 to 200 of about 1,523,799 (296)

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin S. George, Anthony J. Ricci
wiley   +1 more source

The Dispute of Statins and Cholesterol: Can Statins Save Your Life by Abating the Risk of Heart Disease?

, 2018
Md. Sahab Uddin, Muniruddin Ahmed
openalex   +1 more source

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Tofacitinib restores the inhibition of reverse cholesterol transport induced by inflammation: understanding the lipid paradox associated with rheumatoid arthritis.

, 2018
Sandra Pérez Baos, Juan I. Barrasa, Paula Gratal, Ane Larrañaga Vera, Iván Prieto Potin, Gabriel Herrero Beaumont, Raquel Largo, Juan I. Barrasa   +7 more
openalex   +1 more source

Redox‐Responsive Tellurium‐Bridged Covalent Organic Frameworks/PEG Composites for Targeted Therapy of Diabetic Cardiomyopathy

Advanced Science, EarlyView.
This study unlocks the immense potential of COF@polymer nanocomposites as a multifunctional therapeutic platform for targeted drug delivery in diabetic cardiomyopathy. Abstract Diabetic cardiomyopathy, a major complication of diabetes, is strongly associated with elevated levels of glycated hemoglobin (HbA1c) and reactive oxygen species (ROS). However,
Jing Xue, Jialu Zhuang, Taotao Fan, Songtao Tang, Junjun Wang, Xiaohui Liu, Jian Liu, Jin Shi, Jiaji Li, Wanjun Li, Danyou Hu, Xiaoqian Zhang, Hua Wang, Guiyang Zhang   +13 more
wiley   +1 more source

Competition between a transmembrane helix on Scap and a membrane cholesterol regulates Scap-Insig interaction and SREBP activation. [PDF]

Proc Natl Acad Sci U S A
Williams BC, Kober DL, Bai XC, Rosenbaum DM, Radhakrishnan A.   +4 more
europepmc   +1 more source

The U Shaped Relationship Between High-Density Lipoprotein Cholesterol and All-Cause or Cause-Specific Mortality in Adult Population

, 2020
Yu‐Yao Huang, Yang Liu, Kwok Wai Lo, Lei Liu, Yu Yang, Chien‐Yu Chen, Jian Huang, Yingqing Feng, Bing Zhang   +8 more
openalex   +1 more source

A Comparative Study of Body Mass Index, Body Weight and Waist to Height Ratio to Depict Serum Cholesterol Level in Healthy Young Individuals

, 2019
Ankit X. Sharma, Ritwick Ranjan Sarma, Rahul Soni, Nasir Ali Ansari, Nikita Sabu, Pooja Jain, Swati Mittal, Yashi Mathur   +7 more
openalex   +1 more source

Partial Defect in the Cholesterol Side-Chain Cleavage Enzyme P450scc (CYP11A1) Resembling Nonclassic Congenital Lipoid Adrenal Hyperplasia [PDF]

, 2010
Taninee Sahakitrungruang, Meng Kian Tee, Piers R. Blackett, Walter L. Miller   +3 more
openalex   +1 more source

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source