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HDL and Cholesterol Ester Transfer Protein (CETP)
2022Cholesterol ester transfer protein (CETP) is important clinically and is one of the major targets in cardiovascular disease studies. With high conformational flexibility, its tunnel structure allows unforced movement of high-density lipoproteins (HDLs), VLDLs, and LDLs.
Siying, Deng +2 more
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Clinical Biochemistry, 2019 Background: Previous studies revealed decreased level of high-density lipoprotein cholesterol (HDL-C) as important factor for development of colorectal cancer (CRC).
Marija Mihajlovic +2 more
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Potential Inhibitors of the Activity of the Cholesterol-Ester Transfer Protein
Journal of Computational Biology, 2019The cholesterol-ester transfer protein (CETP) exchanges lipids between high-density lipoproteins (HDLs) and low-density lipoproteins (LDLs). The excessive transport of lipids from HDLs to LDLs mediated by this protein can cause an alteration in the deposition of lipoproteins onto the arterial walls, thus promoting the development of arteriosclerosis ...
Tarraga, Wilson Alberto +3 more
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Cholesterol ester transfer protein (CETP) and atherosclerosis
Drug Discovery Today: Therapeutic Strategies, 2007Atherosclerotic cardiovascular disease continues to be a major healthcare problem in developed as well as developing nations. Although adoption of a healthy lifestyle coupled with use of lipid modifying and antithrombotic agents significantly reduces the risk of major cardiovascular events, a significant residual burden remains.
Donna Polk, P.K. Shah
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Effects of an Inhibitor of Cholesteryl Ester Transfer Protein on HDL Cholesterol
New England Journal of Medicine, 2004Decreased high-density lipoprotein (HDL) cholesterol levels constitute a major risk factor for coronary heart disease; however, there are no therapies that substantially raise HDL cholesterol levels. Inhibition of cholesteryl ester transfer protein (CETP) has been proposed as a strategy to raise HDL cholesterol levels.We conducted a single-blind ...
Margaret E, Brousseau +7 more
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The Effects of Cholesterol Ester Transfer Protein Inhibition on Cholesterol Efflux
The American Journal of Cardiology, 2009Cholesterol ester transfer protein (CETP) deficiency or inhibition results in dramatic elevations of high-density lipoprotein (HDL) levels, but there has been concern that HDL might be dysfunctional in its ability to promote efflux of cholesterol from macrophage foam cells or to mediate reverse cholesterol transport.
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Genetic Variations of Cholesterol Ester Transfer Protein Gene in Koreans
Human Biology, 2001An absence of cholesterol ester transfer protein (CETP, protein; CETP, gene) results in an increase of the apolipoprotein AI levels and a decrease in the low density lipoprotein (LDL) levels. Thus, the CETP polymorphism is important in the assessment of risk of atherosclerosis.
S H, Hong, Y R, Kim, J, Song, J Q, Kim
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New Horizons for Cholesterol Ester Transfer Protein Inhibitors
Current Atherosclerosis Reports, 2011High-density lipoprotein (HDL) cholesterol levels bear an inverse relationship to cardiovascular risk. To date, however, no intervention specifically targeting HDL has been demonstrated to reduce cardiovascular risk. Cholesterol ester transfer protein (CETP) mediates transfer of cholesterol ester from HDL to apolipoprotein B-containing particles. Most,
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Cholesterol ester transfer protein: a therapeutic target in atherosclerosis?
Expert Opinion on Therapeutic Targets, 2008CETP has an established role in the transport of cholesterol from the peripheral tissues to the liver for elimination. The fact that CETP was recognized as a target for raising high-density lipoprotein cholesterol (HDL-C) levels has led to research on CETP inhibitors to protect against atherosclerosis.To review the role of CETP as a pivotal target for ...
Ekaterini, Vourvouhaki +1 more
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Cholesterol Ester Transfer Protein (CETP), Postprandial Lipemia and Hypolipidemic Drugs
Current Medicinal Chemistry, 2009Cholesterol ester transfer protein (CETP) plays a significant role in high density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT). A reduction in CETP activity leads to an increase in HDL-cholesterol levels. However, the relationship between reduced CETP function and atherosclerosis is complex and confusing.
G D, Kolovou +3 more
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