Results 251 to 260 of about 53,010 (291)
Some of the next articles are maybe not open access.
Cholesterol Ester Transfer Protein (CETP), Postprandial Lipemia and Hypolipidemic Drugs
Current Medicinal Chemistry, 2009Cholesterol ester transfer protein (CETP) plays a significant role in high density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT). A reduction in CETP activity leads to an increase in HDL-cholesterol levels. However, the relationship between reduced CETP function and atherosclerosis is complex and confusing.
G D, Kolovou +3 more
openaire +2 more sources
Genetic Variations of Cholesterol Ester Transfer Protein Gene in Koreans
Human Biology, 2001An absence of cholesterol ester transfer protein (CETP, protein; CETP, gene) results in an increase of the apolipoprotein AI levels and a decrease in the low density lipoprotein (LDL) levels. Thus, the CETP polymorphism is important in the assessment of risk of atherosclerosis.
S H, Hong, Y R, Kim, J, Song, J Q, Kim
openaire +2 more sources
Cholesteryl Ester Transfer Protein Mutations, Protein Activity and HDL-Cholesterol Concentration
cclm, 1998Abstract We have examined a group of North American subjects, selected to include individuals with a wide variety of HDL-cholesterol concentrations for: 1) mutations in the genes coding for cholesteryl ester transfer protein and hepatic lipase, 2) apolipoprotein E genotype, 3) total cholesterol and triglycerides, 4) HDL-triglycerides ...
S A, Hill, C, Thomson, M J, McQueen
openaire +2 more sources
New Horizons for Cholesterol Ester Transfer Protein Inhibitors
Current Atherosclerosis Reports, 2011High-density lipoprotein (HDL) cholesterol levels bear an inverse relationship to cardiovascular risk. To date, however, no intervention specifically targeting HDL has been demonstrated to reduce cardiovascular risk. Cholesterol ester transfer protein (CETP) mediates transfer of cholesterol ester from HDL to apolipoprotein B-containing particles. Most,
openaire +2 more sources
The Effects of Cholesterol Ester Transfer Protein Inhibition on Cholesterol Efflux
The American Journal of Cardiology, 2009Cholesterol ester transfer protein (CETP) deficiency or inhibition results in dramatic elevations of high-density lipoprotein (HDL) levels, but there has been concern that HDL might be dysfunctional in its ability to promote efflux of cholesterol from macrophage foam cells or to mediate reverse cholesterol transport.
openaire +2 more sources
Cholesteryl ester transfer protein inhibition by PD 140195
Lipids, 1994AbstractThe presence of plasma cholesteryl ester transfer protein (CETP) activity may be atherogenic, and, therefore, strategies to inhibit its activity or production may result in a beneficial effect on lipoprotein profiles and the disease process. The current report describes 4‐phenyl‐5‐tridecyl‐4H‐1,2,4‐triazole‐3‐thiol (PD 140195), a novel CETP ...
C L, Bisgaier +5 more
openaire +2 more sources
Cholesterol ester transfer protein: a therapeutic target in atherosclerosis?
Expert Opinion on Therapeutic Targets, 2008CETP has an established role in the transport of cholesterol from the peripheral tissues to the liver for elimination. The fact that CETP was recognized as a target for raising high-density lipoprotein cholesterol (HDL-C) levels has led to research on CETP inhibitors to protect against atherosclerosis.To review the role of CETP as a pivotal target for ...
Ekaterini, Vourvouhaki +1 more
openaire +2 more sources
Reverse cholesterol transport in mice expressing simian cholesteryl ester transfer protein
Atherosclerosis, 2002The role of cholesteryl ester transfer protein (CETP) in atherogenesis remains ambiguous, as both pro and antiatherogenic effects have been described. Expression of CETP increases HDL-cholesteryl ester turnover, but there is no direct evidence whether CETP mobilizes cholesterol in vivo.
O, Stein +5 more
openaire +2 more sources
Peroxisome Proliferator‐Activated Receptor α Agonists Regulate Cholesterol Ester Transfer Protein
Lipids, 2008AbstractPeroxisome proliferator‐activated receptor α (PPARα) belongs to the nuclear receptor superfamily that regulates multiple target genes involved in lipid metabolism. Cholesterol ester transfer protein (CETP) is a secreted glycoprotein that modifies high‐density lipoprotein (HDL) particles.
Thomas P, Beyer +7 more
openaire +2 more sources
Potential Inhibitors of the Activity of the Cholesterol-Ester Transfer Protein
Journal of Computational Biology, 2019The cholesterol-ester transfer protein (CETP) exchanges lipids between high-density lipoproteins (HDLs) and low-density lipoproteins (LDLs). The excessive transport of lipids from HDLs to LDLs mediated by this protein can cause an alteration in the deposition of lipoproteins onto the arterial walls, thus promoting the development of arteriosclerosis ...
Tarraga, Wilson Alberto +3 more
openaire +3 more sources