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Cholesteryl Ester Transfer Protein Mutations, Protein Activity and HDL-Cholesterol Concentration
cclm, 1998Abstract We have examined a group of North American subjects, selected to include individuals with a wide variety of HDL-cholesterol concentrations for: 1) mutations in the genes coding for cholesteryl ester transfer protein and hepatic lipase, 2) apolipoprotein E genotype, 3) total cholesterol and triglycerides, 4) HDL-triglycerides ...
S A, Hill, C, Thomson, M J, McQueen
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Cholesteryl ester transfer protein inhibition by PD 140195
Lipids, 1994AbstractThe presence of plasma cholesteryl ester transfer protein (CETP) activity may be atherogenic, and, therefore, strategies to inhibit its activity or production may result in a beneficial effect on lipoprotein profiles and the disease process. The current report describes 4‐phenyl‐5‐tridecyl‐4H‐1,2,4‐triazole‐3‐thiol (PD 140195), a novel CETP ...
C L, Bisgaier +5 more
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The Pharmacology and Off-Target Effects of Some Cholesterol Ester Transfer Protein Inhibitors
The American Journal of Cardiology, 2009Inhibitors of cholesterol ester transfer protein (CETP) have the capacity to increase plasma high-density lipoprotein cholesterol to unprecedented levels. Still, hopes that CETP inhibition could reduce atherosclerosis were dented when the clinical development of one such inhibitor, torcetrapib, was halted because of an unexpected finding of increased ...
Vergeer, Menno, Stroes, Erik S. G.
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Reverse cholesterol transport in mice expressing simian cholesteryl ester transfer protein
Atherosclerosis, 2002The role of cholesteryl ester transfer protein (CETP) in atherogenesis remains ambiguous, as both pro and antiatherogenic effects have been described. Expression of CETP increases HDL-cholesteryl ester turnover, but there is no direct evidence whether CETP mobilizes cholesterol in vivo.
O, Stein +5 more
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[Cholesterol ester transfer protein (CETP)].
Nihon rinsho. Japanese journal of clinical medicine, 1995Plasma CETP plays an important role in the reverse cholesterol transport system in conjunction with lecithin:cholesterol acyltransferase (LCAT). CETP mediates transfer of cholesteryl ester from HDL to apo B containing lipoproteins and also mediates transfer of triglyceride from VLDL and IDL to HDL.
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The cholesterol ester transfer protein inhibitor, anacetrapib
Current Opinion in Lipidology, 2011Ishwarlal, Jialal, Jaspreet, Kaur
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Atherosclerosis, 1997
As a result of screening, several isoflavans were identified to be antagonists of cholesterol ester transfer protein (CETP) activity. The present study evaluates CGS 25159, a synthetic isoflavan, as a putative inhibitor of CETP activity of human and hamster plasma.
H V, Kothari +3 more
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As a result of screening, several isoflavans were identified to be antagonists of cholesterol ester transfer protein (CETP) activity. The present study evaluates CGS 25159, a synthetic isoflavan, as a putative inhibitor of CETP activity of human and hamster plasma.
H V, Kothari +3 more
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[HDL and reverse cholesterol transport. Role of cholesterol ester transfer protein].
Comptes rendus des seances de la Societe de biologie et de ses filiales, 1993As most of peripheral cells are not able to catabolize cholesterol, the transport of cholesterol excess from peripheral tissues back to the liver, namely "reverse cholesterol transport", is the only way by which cholesterol homeostasis is maintained in vivo.
L, Lagrost, P, Gambert
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[Cholesterol ester transfer protein. A major player in cholesterol metabolism].
Ugeskrift for laeger, 1999Plasma cholesterol transfer protein (P-CETP) plays a central role in cholesterol metabolism by pronroting transfer of cholesteryl esters from high density lipoprotein (HDL) to very low density lipoproteins in exchange for triglycerides. The CETP-reaction may hereby be a critical factor in reverse cholesterol transport, i.e., the transfer of cholesterol
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1989
More than 80% of the cholesteryl esters (CE) found in human plasma derive from the reaction of lecithin: cholesterol acyl transferase (LCAT). Since the content of CE in plasma high positively correlates with the incidence of atherosclerosis and myocardial infarction, there has been in the past and still is great interest in investigation of the enzymes
G. M. Kostner, E. Steyrer
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More than 80% of the cholesteryl esters (CE) found in human plasma derive from the reaction of lecithin: cholesterol acyl transferase (LCAT). Since the content of CE in plasma high positively correlates with the incidence of atherosclerosis and myocardial infarction, there has been in the past and still is great interest in investigation of the enzymes
G. M. Kostner, E. Steyrer
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