Results 231 to 240 of about 1,222,670 (353)

The effects of house dust-derived mixtures of organophosphate esters on Leydig cell phenotype, function, and lipidome†. [PDF]

Biol Reprod
Li Z, Wang X, Hales BF, Robaire B.
europepmc   +1 more source

Associations of Vestibular Disorders With Risk of All‐Cause and Cause‐Specific Dementia: A Longitudinal Cohort Study in UK Biobank

Sensory Neuroscience, EarlyView.
ABSTRACT To explore associations of vestibular disorders with all‐cause and cause‐specific dementia and underlying biological mechanisms/neuroimaging changes. A population‐based cohort study of 406,348 UK Biobank participants was conducted. Inverse probability of treatment weighting (IPTW) balanced baseline covariates, and Cox proportional hazards ...
Xiaofei Li, Fan Jiang, Qiuyue Dong, Hao Chen, Hanbing Ji, Alimu Dayimu, Yifan Yu, Guorong Li, Na Li, Peipei Fu, Qi Jing, Maoli Duan, Hongkai Li, Shanquan Chen, Daogong Zhang, Haibo Wang   +15 more
wiley   +1 more source

ACAT-1, Cav-1 and PrP expression in scrapie susceptible and resistant sheep

Open Life Sciences, 2010
Orrù Cristina, Abete Claudia, Dolores Cannas M., Mulas Claudia, Norfo Claudia, Mandas Antonella, Vascellari Sarah, Colla Paolo, Dessì Sandra, Pani Alessandra   +9 more
doaj   +1 more source

Perinatal vitamin A excess impacts vitamin A and lipid metabolism in rat offspring. [PDF]

Sci Rep
Berthomé A, Antoine T, Meiller L, Govers R, Guichard P, Sabran C, Gonzalez T, Nowicki M, Bordat C, Borel P, Grino M, Sauvinet V, Reboul E.   +12 more
europepmc   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Structural basis for inhibition of Mycobacterium tuberculosis α-methylacyl-CoA racemase by 2-arylthiopropanoyl-CoA inhibitor analogs. [PDF]

J Biol Chem
Mojanaga OO, Woodman TJ, Lloyd MD, Acharya KR.   +3 more
europepmc   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Lysosomal acid lipase deficiency: The forgotten link between liver and cardiovascular disease. [PDF]

World J Cardiol
Fornengo P, Ferro A, Fagoonee S, Rinaudo E, Amione C, Durazzo M.   +5 more
europepmc   +1 more source

Decoding pH‐Driven Phase Transition of Lipid Nanoparticles

Small, EarlyView.
Ionizable aminolipids govern lipid nanoparticle (LNP) function through environment‐dependent protonation. Constant‐pH molecular dynamics reveal intrinsic, apparent, and surface pKa${\rm pK}_{\text{a}}$ values within LNP‐mimetic membranes, demonstrating that the LNP lipid environment induces a pronounced downward pKa${\rm pK}_{\text{a}}$ shift exceeding
Marius F.W. Trollmann, Rainer A. Böckmann   +1 more
wiley   +1 more source

The Role of Lipid Alteration in Multiple Sclerosis. [PDF]

Int J Mol Sci
Damiza-Detmer A, Pawełczyk M, Głąbiński A.   +2 more
europepmc   +1 more source