Results 11 to 20 of about 588,707 (355)

Non-Coding RNAs as Critical Modulators of Cholesterol Metabolism in Cancer [PDF]

Biomedicines
Cholesterol metabolism reprogramming helps tumor cells meet their high energy and biosynthetic needs. Many studies link high cholesterol levels to a higher risk of cancers, such as breast, prostate, and colorectal cancer.
Chunyu Zhang, Zhiwei Miao, Yan Xu, Tongguo Shi   +3 more
doaj   +2 more sources

Research progress on cholesterol metabolism and tumor therapy [PDF]

Discover Oncology
Cholesterol and its metabolic derivatives have important biological functions and are crucial in tumor initiation, progression, and treatment. Cholesterol maintains the physical properties of cellular membranes and is pivotal in cell signal transduction.
Zewen Chu, Lei Fang, Yanwei Xiang, Yue Ding   +3 more
doaj   +2 more sources

The Role of Cholesterol Metabolism and Its Regulation in Tumor Development [PDF]

Cancer Medicine
Background Within the tumor microenvironment, tumor cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in the extracellular milieu.
Yongmei Wu, Wenqian Song, Min Su, Jing He, Rong Hu, Youbo Zhao   +5 more
doaj   +2 more sources

Coronavirus Infection and Cholesterol Metabolism

Frontiers in Immunology, 2022
Host cholesterol metabolism remodeling is significantly associated with the spread of human pathogenic coronaviruses, suggesting virus-host relationships could be affected by cholesterol-modifying drugs.
Jun Dai, Jun Dai, Jun Dai, Huan Wang, Ying Liao, Lei Tan, Yingjie Sun, Cuiping Song, Weiwei Liu, Xusheng Qiu, Chan Ding, Chan Ding   +11 more
doaj   +1 more source

Cholesterol Metabolism and Its Regulation by Functional Foods [PDF]

, 2016
Currently, obesity is considered an epidemic due to the disruptions it causes to health, highlighting the incensement in cardiovascular diseases associated with cholesterol and low-density lipoprotein (LDL) high concentrations.
Cristian, J. (Jimenez-Martinez), David, B. (Betancur-Ancona), Gloria, D. (Davila-Ortiz), Luis, C. (Chel-Guerrero), Yasser, C. (Chim-Chi)   +4 more
core   +1 more source

The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease [PDF]

, 2020
Objective Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington’s disease (HD).
Alves, Sandro, Betuing, Sandrine, Caboche, Jocelyne, Carmo-Silva, Sara, Cartier, Nathalie, Conceição, André, Costa, Rafael G, Koppenol, Rebekah, Marcelo, Adriana, Matos, Carlos A, Nunes, Ricardo, Nóbrega, Clévio, Sequeira, Raquel L.   +12 more
core   +1 more source

Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice [PDF]

, 2010
Failure to express or expression of dysfunctional low-density lipoprotein receptors (LDLR) causes familial hypercholesterolemia in humans, a disease characterized by elevated blood cholesterol concentrations, xanthomas, and coronary heart disease ...
Benson, G. Martin, C. Connor, Susan, C. Grimsditch, David, G. Reid, David, Kian Kai, Cheng, L. Griffin, Julian   +5 more
core   +1 more source

An integrated mathematical model of cellular cholesterol biosynthesis and lipoprotein metabolism [PDF]

, 2018
Cholesterol regulation is an important aspect of human health. In this work we bring together and extend two recent mathematical models describing cholesterol biosynthesis and lipoprotein endocytosis to create an integrated model of lipoprotein ...
Pool, Frances, Sweby, Peter K., Tindall, Marcus J.   +2 more
core   +2 more sources

Dendrogenin A drives LXR to trigger lethal autophagy in cancers

Nature Communications, 2017
Dendrogenin A, cholesterol metabolite, has tumor suppressive properties but the mechanisms are unknown. Here the authors show that Dendrogenin A can induce autophagy-mediated cell death in both melanoma and acute myeloid leukaemia.
Gregory Segala, Marion David, Philippe de Medina, Mathias C. Poirot, Nizar Serhan, François Vergez, Aurelie Mougel, Estelle Saland, Kevin Carayon, Julie Leignadier, Nicolas Caron, Maud Voisin, Julia Cherier, Laetitia Ligat, Frederic Lopez, Emmanuel Noguer, Arnaud Rives, Bruno Payré, Talal al Saati, Antonin Lamaziere, Gaëtan Despres, Jean-Marc Lobaccaro, Silvere Baron, Cecile Demur, Fabienne de Toni, Clément Larrue, Helena Boutzen, Fabienne Thomas, Jean-Emmanuel Sarry, Marie Tosolini, Didier Picard, Michel Record, Christian Récher, Marc Poirot, Sandrine Silvente-Poirot   +34 more
doaj   +1 more source

Cholesterol Metabolism and Immunity [PDF]

New England Journal of Medicine, 2014
A study in mice implicates a cholesterol derivative in damping down the inflammatory response mediated by interleukin-1β and explaining, at least in part, the immunosuppressive effect of type I interferon, which is used in the treatment of multiple sclerosis.
openaire   +4 more sources