Results 241 to 250 of about 588,707 (355)

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Single-cell and bulk transcriptome analyses revealed the role of macrophage cholesterol metabolism in atherosclerosis. [PDF]

Lipids Health Dis
Ke J, Chen S, Li L, Liao C, Peng F, Chai D, Lin J.   +6 more
europepmc   +1 more source

Effect of rice bran hemicellulose on the cholesterol metabolism in rats.

, 1989
Seiichiro Aoe, Fukio OHTA, Yuko AYANO
openalex   +2 more sources

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

Advanced Science, EarlyView.
Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen, Jingrui Zhong, Xiaochun Zhang, Jingke Chen, Lin Guo, Xiaoliang Xiong, Xiaonan Zhang, Xiangyu Liu, Bailong Xiao, Boxue Tian   +9 more
wiley   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Clinofibrate Disrupts the SNORA80B/YTHDC1-Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC. [PDF]

Adv Sci (Weinh)
Yuan H, Ge G, Liu L, Hu S, Tian M, Nie Y, Zhao Z, Song Y.   +7 more
europepmc   +1 more source

STUDIES IN CHOLESTEROL METABOLISM : 2. Blood Cholesterol in Various Conditions.

, 1932
John M. McEachern, C. R. Gilmour
openalex   +1 more source

Regulation of Intracellular Cholesterol Metabolism.

, 1995
Ryuichiro Sato, Tatsuya Takano
openalex   +2 more sources

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

TDP-43 dysregulation impairs cholesterol metabolism linked with myelination defects. [PDF]

Acta Neuropathol
García-Toledo I, Godoy-Corchuelo JM, Fernández-Beltrán LC, Ali Z, Guindo-Arroyo A, Jiménez-Coca I, Jiménez-Rodríguez J, Javaloyes-García K, Viñuela M, Gómez-Pinedo U, Saiz-Aúz L, Rábano A, Área-Gómez E, Cunningham TJ, Corrochano S.   +14 more
europepmc   +1 more source