Results 251 to 260 of about 586,832 (295)
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Cholesterol metabolism and embryogenesis
Trends in Genetics, 1998Although cholesterol has long been known to be an essential component of cell membranes in vertebrate organisms, recent studies have suggested that cholesterol plays a crucial role in specific processes during embryonic development, including the covalent modification of Hedgehog proteins.
Joachim Herz
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Regulation of Cholesterol Metabolism
New England Journal of Medicine, 1970Absorption of Cholesterol Mechanisms of cholesterol absorption. The second source of cholesterol entering the miscible pools is dietary or exogenous cholesterol.
J M, Dietschy, J D, Wilson
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Cholesterol metabolism deficiency
2013Genetic defects in enzymes responsible for cholesterol biosynthesis have emerged as important causes of congenital dysmorphology and retardation syndromes. Cholesterol is an important constituent of the cell membrane of most eukaryotic cells, in myelin formation in the brain, spinal cord, and peripheral nervous system, and acts as the precursor for ...
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Cholesterol metabolism and aging
The American Journal of Medicine, 1987Changes occur in lipid and lipoprotein concentrations with age that increase the risk of developing atherosclerotic disease. In children and young adults (less than 20 years of age), the plasma total cholesterol concentration decreases between the ages of 10 and 20 years. After age 20, the plasma total cholesterol concentration increases progressively,
R A, Kreisberg, S, Kasim
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Cholesterol Absorption and Metabolism
2009Inhibitors of cholesterol absorption have been sought for decades as a means to treat and prevent cardiovascular diseases (CVDs) associated with hypercholesterolemia. Ezetimibe is the one clear success story in this regard, and other compounds with similar efficacy continue to be sought.
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Genetics and cholesterol metabolism
Current Opinion in Lipidology, 1996The regulation of cholesterol metabolism by both genetic and environmental factors seems to be very complex. The recent research approach focusing on the genetic control of many key regulatory processes of cholesterol homeostasis has, however, started to elucidate the importance of genetic variation in susceptibility to a number of common clinical ...
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Phytosterols and cholesterol metabolism
Current Opinion in Lipidology, 2004Phytosterols are plant sterols structurally similar to cholesterol that act in the intestine to lower cholesterol absorption. Because they have very low systemic absorption and are already present in healthy diets, increasing the intake of phytosterols may be a practical way to reduce coronary heart disease with minimum risk.Phytosterols displace ...
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CHOLESTEROL-METABOLIZING CYTOCHROMES P450
Drug Metabolism and Disposition, 2006By catalyzing the first steps in different pathways of cholesterol degradation, cytochromes P450 (P450s) 7A1, 27A1, 11A1, and 46A1 play key roles in cholesterol homeostasis. CYP7A1 is a microsomal liver-specific enzyme that converts cholesterol to 7alpha-hydroxycholesterol.
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Cholesterol biosynthesis and metabolism
Cardiovascular Drugs and Therapy, 1992Cholesterol plays an essential role in cell membrane synthesis and in cell growth and differentiation. In mammalian cells, cholesterol can be synthesized from acetate precursors or taken up from dietary or exogenous sources. The major catabolic route for disposal of cholesterol involves conversion into excretable bile acids.
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