Results 161 to 170 of about 441,731 (309)

Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats. [PDF]

Heliyon, 2023
Jin SW, Han YL, Pan XL, Zhang HX.
europepmc   +1 more source

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

Advanced Science, EarlyView.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai, Siying Cheng, Fengguang Ma, Xiaorong Zhang, Jianan Huang, Zhonghua Liu, Bing Hu   +6 more
wiley   +1 more source

Hepatic management of toxic sterols after acute deletion of Cyp51 from cholesterol synthesis. [PDF]

J Biol Chem
Kreft T, Blagotinšek Cokan K, Skubic C, Režen T, Perše M, Wechtersbach K, Kojc N, Jeruc J, Debeljak Ž, Heffer M, Matz-Soja M, Rozman D.   +11 more
europepmc   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterol. [PDF]

EBioMedicine
Förster F, Horn K, Pott J, Delgado GE, Kleber ME, März W, Moissl-Blanke AP, Silbernagel G, Waldenberger M, Grallert H, Peters A, Gieger C, Baber R, Kirsten H, Loeffler M, Isermann B, Thiery J, Kovacs P, Tönjes A, Stumvoll M, Gylling H, Kähönen M, Lehtimäki T, Mishra PP, Raitakari O, Ceglarek U, Scholz M.   +26 more
europepmc   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

The Adaptation of Cancer Cells to Serum Deprivation Is Mediated by mTOR-Dependent Cholesterol Synthesis. [PDF]

Int J Mol Sci
Ilyassova B, Rakhimgerey N, Rakhimova S, Satvaldina N, Daniyarov A, Akilzhanova A, Kairov U, Begimbetova D, Sarbassov DD.   +8 more
europepmc   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Inhibiting cholesterol synthesis halts rhabdomyosarcoma growth via ER stress and cell cycle arrest. [PDF]

EMBO Mol Med
Gizaw NY, Kolari K, Kallio P, Alitalo K, Kivelä R.   +4 more
europepmc   +1 more source

ChREBP refines the hepatic response to fructose to protect the liver from injury [PDF]

, 2017
Angela M. Hall, Brian N. Finck, Hetz, Montgomery   +3 more
core   +3 more sources