Results 31 to 40 of about 441,731 (309)
Journal of Lipid Research, 2000 We determined the extent to which diurnal variation in cholesterol synthesis in liver is controlled by steady-state mRNA levels for the rate-limiting enzyme in the pathway, hydroxymethylglutaryl (HMG)-CoA reductase.
Helga Jurevics +4 more
doaj +1 more source
Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia [PDF]
, 1984 A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
Cummings +9 more
core +1 more source
Cholesterol synthesis in the perfused liver of pregnant hamsters
Journal of Lipid Research, 1987 Pregnancy is a risk factor for the development of cholesterol gallstones. In pregnant women, biliary cholesterol saturation and secretion are increased.
J Reichen, G Karlaganis, F Kern, Jr
doaj +1 more source
Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. [PDF]
, 2015 Palmitic acid (PA) induces hepatocyte apoptosis and fuels de novo ceramide synthesis in the endoplasmic reticulum (ER). Myristic acid (MA), a free fatty acid highly abundant in copra/palmist oils, is a predictor of nonalcoholic steatohepatitis (NASH) and
Alarcón-Vila, C +9 more
core +2 more sources
Journal of Lipid Research, 1982 The contribution of de novo synthesis to the secretion of cholesterol and lecithin in bile was assessed in isolated rat livers, perfused with a lipid-free medium.
S J Robins, H Brunengraber
doaj +1 more source
Effect of evolocumab on cholesterol synthesis and absorption[S]
Journal of Lipid Research, 2016 The effects of cholesterol-lowering drugs, including those that reduce cholesterol synthesis (statins) and those that reduce cholesterol absorption (ezetimibe), on cholesterol absorption and synthesis are well understood. Proprotein convertase subtilisin/
Matthew Peach +7 more
doaj +1 more source
Alterations of intestinal lipoprotein metabolism in diabetes mellitus and metabolic syndrome [PDF]
, 2015 Diabetes and metabolic syndrome are associated with abnormal postprandial lipoprotein metabolism, with a significant delay in the clearance of many lipid parameters, including triglycerides and chylomicrons.
ARCA, Marcello
core +1 more source
Journal of Lipid Research, 2000 The Smith-Lemli-Opitz syndrome (SLOS) is a multiple malformation/mental retardation syndrome caused by a deficiency of the enzyme 7-dehydrocholesterol Δ7-reductase.
Robert D. Steiner +4 more
doaj +1 more source
Effects of dietary cholesterol on the regulation of total body cholesterol in man
Journal of Lipid Research, 1971 Studies on the interaction of cholesterol absorption, synthesis, and excretion were carried out in eight patients using sterol balance techniques. Absorption of dietary cholesterol was found to increase with intake; up to 1 g of cholesterol was absorbed ...
EDER QUINTÃO +2 more
doaj +1 more source
Cholesterol Synthesis, Cholesterol Absorption, and Mortality in Hemodialysis Patients [PDF]
Clinical Journal of the American Society of Nephrology, 2012 Summary Background and objectives Recent clinical trials on cholesterol-lowering in patients with CKD yielded conflicting results, which might have resulted from different treatment strategies. Serum cholesterol levels are determined by endogenous synthesis and intestinal absorption, which are differentially ...
Kyrill S, Rogacev +10 more
openaire +2 more sources