Results 51 to 60 of about 441,731 (309)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. [PDF]

, 2019
Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper-activated cholesterol-biosynthesis program that is strongly linked to nuclear ...
Bold, Richard J, Borowsky, Alexander D, Cai, Demin, Chen, Hong-Wu, Chen, Xinbin, Evans, Ronald M, Fiehn, Oliver, Gao, Bei, Huang, Zenghong, Jiang, Yuqian, Kung, Hsing-Jien, Lam, Kit S, Lara, Primo N, Li, Jian Jian, Li, Jin, To, Ka-Fai, Wang, Junjian, Wu, Feng, Xu, Jianzhen, Zhao, Ruqian, Zou, Hongye, Zou, June X   +21 more
core  

Metabolic fates of isovaleric acid and isovalthine in rats [PDF]

, 1966
1. Isovaleric acid-1-C14, -4-C14, or C14-CaC03 with or without non-isotopic isovaleric acid was orally administered to rats and the incorporation of these isotopes into liver cholesterol, fatty acid, or urinary isovalthine was examined. 2.
Azumi, Tsukasa, Fujii, Yoshiro, Kodama, Hiroyuki, Shimomura, Takehira   +3 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Changes in cholesterol absorption and cholesterol synthesis caused by ezetimibe and/or simvastatin in men

Journal of Lipid Research, 2009
This study evaluates changes in cholesterol balance in hypercholesterolemic subjects following treatment with an inhibitor of cholesterol absorption or cholesterol synthesis or coadministration of both agents. This was a randomized, double blind, placebo-
Thomas Sudhop, Michael Reber, Diane Tribble, Aditi Sapre, William Taggart, Patrice Gibbons, Thomas Musliner, Klaus von Bergmann, Dieter Lütjohann   +8 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Role of cholesterol synthesis in regulation of bile acid synthesis and biliary cholesterol secretion in humans.

Journal of Lipid Research, 1991
We used lovastatin, a specific inhibitor of HMG-CoA reductase, to study the role of cholesterol synthesis in regulation of both bile acid synthesis, measured by release of 14CO2 from [26-14C]cholesterol, and biliary cholesterol secretion, measured by ...
JC Mitchell, BG Stone, GM Logan, WC Duane   +3 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits

Journal of Lipid Research, 2000
We investigated the effect of ileal bile acid transport on the regulation of classic and alternative bile acid synthesis in cholesterol-fed rats and rabbits.
Guorong Xu, Benjamin L. Shneider, Sarah Shefer, Lien B. Nguyen, Ashok K. Batta, G. Stephen Tint, Marco Arrese, Sundararajah Thevananther, Lin Ma, Siegfried Stengelin, Werner Kramer, David Greenblatt, Mark Pcolinsky, Gerald Salen   +13 more
doaj   +1 more source

Investigation of \u3cem\u3ede novo\u3c/em\u3e cholesterol synthetic capacity in the gonads of goldfish (\u3cem\u3eCarassius auratus\u3c/em\u3e) exposed to the phytosterol beta-sitosterol [PDF]

, 2006
Total and intra-mitochondrial gonadal cholesterol concentrations are decreased in fish exposed to the phytoestrogen beta-sitosterol (beta-sit). The present study examined the potential for beta-sit to disrupt de novo cholesterol synthesis in the gonads ...
Drolet, Melissa, MacLatchy, Deborah L., Sharpe, Rainie L.   +2 more
core   +1 more source