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Anacetrapib, a cholesteryl ester transfer protein inhibitor
Expert Opinion on Investigational Drugs, 2011Inhibition of cholesteryl ester transfer protein (CETP) has the ability to increase high-density lipoprotein (HDL)-cholesterol levels and potentially reduce cardiovascular risk. The first CETP inhibitor, torcetrapib, was discontinued due to off-target effects resulting in increased mortality.
Amanda J, Hooper, John R, Burnett
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Cholesteryl Ester Transfer Protein; An Enigmatic Protein
Hormone Research, 2008The cholesteryl ester transfer protein (CETP) mediates the transfer of cholesteryl esters from high-density lipoproteins (HDL) into very-low-density lipoproteins (VLDL) with a reciprocal exchange of triglycerides. Plasma CETP is mainly bound to HDL and is involved in the interconversion of these lipoproteins.
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Dalcetrapib, a cholesteryl ester transfer protein modulator
Expert Opinion on Investigational Drugs, 2012Cholesteryl ester transfer protein (CETP) plays an important role in reverse cholesterol transport by transferring cholesteryl esters from high-density lipoprotein (HDL) to the apolipoprotein B-containing lipoproteins. Inhibition of CETP is a target to increase HDL-cholesterol and potentially reduce atherosclerosis.
Amanda J, Hooper, John R, Burnett
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1996
Cholesteryl ester transfer protein (CETP) mediates the exchange of cholesteryl esters and triglycerides between lipoproteins in the plasma. In studies dealing with the mechanism of CETP-mediated lipid transfer, we have examined the effects of several classes of biomolecules, including apolipoproteins and related synthetic peptides, cholesteryl sulfate,
D T, Connolly +3 more
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Cholesteryl ester transfer protein (CETP) mediates the exchange of cholesteryl esters and triglycerides between lipoproteins in the plasma. In studies dealing with the mechanism of CETP-mediated lipid transfer, we have examined the effects of several classes of biomolecules, including apolipoproteins and related synthetic peptides, cholesteryl sulfate,
D T, Connolly +3 more
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Refocusing On Use of Cholesteryl Ester Transfer Protein Inhibitors
The American Journal of Cardiology, 2007Cholesteryl ester transfer protein (CETP) plays an important role in cholesterol metabolism because it is responsible for the transfer of cholesteryl esters from high-density lipoprotein (HDL) to very-low-density lipoproteins and low-density lipoproteins (LDLs). The development of CETP inhibitors represented a novel approach for raising HDL cholesterol
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Cholesteryl ester transfer protein inhibitors
Expert Opinion on Therapeutic Patents, 2001As well as hypercholesterolaemia, low levels of high-density lipoprotein cholesterol (HDL-C) are critical risk factors for atherosclerosis and coronary heart disease (CHD). Although fibrate, simvastatin and niacin can be used for the treatment of a low HDL-C level, their effects, however, are not wholly satisfactory.
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Cholesteryl Ester Transfer Protein and Atherogenesis
Annals of the New York Academy of Sciences, 1997A, Tall +6 more
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Cholesteryl Ester Transfer Protein Inhibition: A Dysfunctional Endothelium
Journal of Cardiovascular Pharmacology, 2010Westerterp, Marit +2 more
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Triacylglycerol And Cholesteryl Ester Transfer Protein
Nutrition Reviews, 2009openaire +2 more sources