Results 211 to 220 of about 32,808 (269)

Cholesteryl ester transfer protein and atherosclerosis

Current Opinion in Lipidology, 2000
Plasma cholesteryl ester transfer protein facilitates the transfer of cholesteryl ester from HDL to apolipoprotein B-containing lipoproteins. Its significance in atherosclerosis has been debated in studies of human population genetics and transgenic mice.
A, Inazu, J, Koizumi, H, Mabuchi
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Cholesteryl Ester Transfer Protein (CETP) Inhibitors

Current Topics in Medicinal Chemistry, 2009
Epidemiological studies have demonstrated an inverse correlation between plasma concentrations of high-density lipoprotein cholesterol (HDL-C) and incidence of coronary heart disease (CHD); thus new therapies for raising HDL-C levels have been the focus of significant efforts by the cardiovascular medicine community.
Julianne A, Hunt, Zhijian, Lu
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Cholesteryl ester analogs inhibit cholesteryl ester but not triglyceride transfer catalyzed by the plasma cholesteryl ester‐triglyceride transfer protein

Lipids, 1990
AbstractA lipid transfer protein complex (LTC), purified from human plasma by immunoaffinity chromatography, catalyzed the interlipoprotein transfer of cholesteryl esters (CE) and triglycerides (TG). The CE transfer activity of LTC was governed by the strucutre of the CE. Incubation of LTC with long chain CE both activated and stabilized LTC.
S J, Busch, J A, Harmony
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Cholesteryl Ester Transfer Protein Influences High‐Density Lipoprotein Levels and Survival in Sepsis

American Journal of Respiratory and Critical Care Medicine, 2019
Rationale: High‐density lipoprotein (HDL) cholesterol (HDL‐C) levels decline during sepsis, and lower levels are associated with worse survival. However, the genetic mechanisms underlying changes in HDL‐C during sepsis, and whether the relationship with ...
M. Trinder, K. Genga, H. Kong, L. Blauw, C. Lo, Xuan Li, M. Cirstea, Yanan Wang, P. Rensen, J. Russell, K. Walley, J. Boyd, L. Brunham   +12 more
semanticscholar   +1 more source

The effects of curcumin and a modified curcumin formulation on serum Cholesteryl Ester Transfer Protein concentrations in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial

Avicenna Journal of Phytomedicine, 2018
Objective: Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesteryl ester from HDL-C to LDL-C and VLDL-C. The aim of the present trial was to evaluate the effect of curcumin and its modified formulation on serum CETP concentrations ...
Ali Javandoost, A. Afshari, M. Saberi-Karimian, Amirhosein Sahebkar, Hamideh Safarian, Malihe Moammeri, Behdokht Fathi Dizaji, S. Tavalaei, Gordon A Ferns, Alireza Pasdar, S. Parizadeh, M. Ghayour-Mobarhan   +11 more
semanticscholar   +1 more source

Cholesteryl Ester Transfer Protein; An Enigmatic Protein

Hormone Research, 1996
The cholesteryl ester transfer protein (CETP) mediates the transfer of cholesteryl esters from high-density lipoproteins (HDL) into very-low-density lipoproteins (VLDL) with a reciprocal exchange of triglycerides. Plasma CETP is mainly bound to HDL and is involved in the interconversion of these lipoproteins.
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Cholesteryl ester transfer protein and its inhibition

Cellular and Molecular Life Sciences, 2010
Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that facilitates the transfer of cholesteryl esters from the atheroprotective high density lipoprotein (HDL) to the proatherogenic low density lipoprotein cholesterol (LDL) and very low density lipoprotein cholesterol (VLDL) leading to lower levels of HDL but raising the levels of ...
Olaf, Weber, Hilmar, Bischoff, Carsten, Schmeck, Michael-Friedrich, Böttcher   +3 more
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Future of Cholesteryl Ester Transfer Protein Inhibitors

Annual Review of Medicine, 2014
The cholesteryl ester transfer protein (CETP) plays an integral role in the metabolism of plasma lipoproteins. Despite two failures, CETP inhibitors are still in clinical development. We review the genetics of CETP and coronary disease, preclinical data on CETP inhibition and atherosclerosis, and the effects of CETP inhibition on cholesterol efflux ...
Daniel J, Rader, Emil M, deGoma
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Cholesteryl ester transfer protein in human brain

International Journal of Clinical and Laboratory Research, 1992
The evidence that apolipoproteins are found in the cerebrospinal fluid and low-density lipoprotein receptor is found in the brain suggests that the brain may have an active lipid transport system. In plasma, cholesteryl ester transfer protein mediates the exchange and net transfer of cholesteryl ester and triglycerides among lipoproteins.
J J, Albers, J H, Tollefson, G, Wolfbauer, R E, Albright   +3 more
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Cholesteryl ester transfer protein inhibitors

Expert Opinion on Therapeutic Patents, 2001
As well as hypercholesterolaemia, low levels of high-density lipoprotein cholesterol (HDL-C) are critical risk factors for atherosclerosis and coronary heart disease (CHD). Although fibrate, simvastatin and niacin can be used for the treatment of a low HDL-C level, their effects, however, are not wholly satisfactory.
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