Spontaneous neuronal network activity is critical for circuit maturation, yet whether this is a feature of enteric nervous system development has yet to be established. Here, we identify clustered ripples, a previously undescribed form of neurogenic gastrointestinal motility that shares many features with spontaneous neuronal networks in other systems.
Lori B. Dershowitz+4 more
wiley +1 more source
Combined Effects of Intermittent Hypoxia and Amyloid Beta on Hippocampal Activity, Its Cholinergic Modulation, and Memory. [PDF]
Pinedo-Vargas L+4 more
europepmc +1 more source
Abstract Background Cyclic vomiting syndrome (CVS) and cannabinoid hyperemesis syndrome (CHS) are both characterized by episodic, acute transitions from asymptomatic states to highly symptomatic states of nausea, repetitive vomiting, and often severe abdominal pain.
David J. Levinthal+2 more
wiley +1 more source
Sea Cucumber Hydrolysates Alleviate Cognitive Deficits in D-Galactose-Induced C57BL/6J Aging Mice Associated with Modulation of Gut Microbiota. [PDF]
Gong H, Zhao H, Mao X.
europepmc +1 more source
Disorders of gut–brain interaction through the lens of polyvagal theory
This paper introduces a metric, vagal efficiency (VE), that tracks a brainstem “switching” mechanism regulating blood pressure's effect on vagal control of the heart and gut. Potentially offering insights into gut–brain interaction disorders. Abstract This paper introduces a metric capable of tracking a hypothetical brainstem “switching” mechanism ...
Stephen W. Porges
wiley +1 more source
Human and rat ex vivo sweat glands for the observation of acetylcholine induced intracellular calcium signalling. [PDF]
Buck TF+3 more
europepmc +1 more source
The role of reactive enteric glia‐macrophage interactions in acute and chronic inflammation
Abstract Enteric glia are a heterogeneous population of peripheral glia within the enteric nervous system and play pivotal roles in gut homeostasis, tissue integrity, coordination of motility, and intestinal immune responses. Under physiological conditions, they communicate with enteric neurons to control intestinal motility.
Schneider Reiner+4 more
wiley +1 more source
Chemotherapy‐Induced Neuropathy Affecting the Gastrointestinal Tract
Chemotherapy (with/without immunotherapy/radiotherapy) may induce neurotoxic effects on the gastrointestinal innervation. Chemotherapy‐induced enteric neuropathy (CIEN) and, probably, neurotoxicity affecting the extrinsic innervation of the gut and the brain underlie the frequent and impactful gut dysfunctions and brain–gut axis (BGA) disorders ...
Gema Vera, Kulmira Nurgali, Raquel Abalo
wiley +1 more source
Epithelial genetic muscarinic receptor 3 ablation induces sex-specific modulation of colonic intestinal progenitor cells and response to intestinal injury. [PDF]
Ragab M+15 more
europepmc +1 more source