Results 261 to 270 of about 345,248 (352)

circPDE4B downregulation triggers GEMIN5‑dependent translational stress response and autophagy to reduce MAPT pathology

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Circular RNAs (circRNAs) are emerging as key regulators of gene expression, synaptic plasticity, and neuronal function in Alzheimer's disease (AD). Here, we characterize the biological actions of circPDE4B, a highly expressed circRNA markedly reduced in AD. METHODS circPDE4B knockdown in neuronal progenitor cells was combined with
Sambhavi Puri, Sophie J. F. van der Spek, Mintao Lin, Zihan Wang, Jacob Porter, Junming Hu, Liyuan Hu, Alejandro N. Rondón‐Ortiz, Alexander Knyshov, Jenna L. Libera, Scott E. Counts, Debomoy K. Lahiri, Julia TCW, Andrew Emili, Xiaoling Zhang, Benjamin Wolozin   +15 more
wiley   +1 more source

Adolescent adversity persistently induces proinflammatory HMGB1 signaling and disrupts the basal forebrain cholinergic system in female rats. [PDF]

Neurobiol Stress
Ross H, Adelman M, Castillo JE, Walker A, Latham J, Qin L, Macht V, Crews FT, Vetreno RP.   +8 more
europepmc   +1 more source

Niacin promotes motor function recovery after spinal cord injury via Hcar2‐dependent microglia immunometabolic regulation

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• The activation of the microglial Hcar2 receptor by niacin initiates intracellular signalling that induces metabolic reprogramming. • This metabolic shift is characterized by increased oxidative phosphorylation. Consequently, microglia polarize from a proinflammatory state toward an anti‐inflammatory, reparative phenotype.
Hua Du, Lingnian Zeng, Chan Liu, Huyao Zhou, Xia Wang, Qing Ai, Jinpiao Zhu, Nong Xiao   +7 more
wiley   +1 more source

Chronic stress alters neurotransmitter co-expression and disrupts context discrimination in a sex-dependent manner. [PDF]

IBRO Neurosci Rep
Mazon C, Betters R, Salmeron-Ceballos G, Tomaziefski A, Coffman C, Simonson R, Tunc-Ozcan E.   +6 more
europepmc   +1 more source

Endogenous Recovery of Fasting C‐Peptide Decreases Progression of Sudomotor Small‐Fibre Dysfunction in Adults With Diabetes: A Real‐World Cohort Study

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 4, May 2026.
ABSTRACT Aims To determine whether recovery of fasting C‐peptide (ΔFCP) reduces deterioration in sudomotor small‐fibre function, whether a threshold exists, and whether associations are complication‐specific. Methods Retrospective real‐world cohort of 288 hospitalised adults with diabetes with repeated fasting C‐peptide and Sudoscan electrochemical ...
Qingyun Cai, Ting Xie, Hongjian Gong, Wenjie Zhang, Lixin Guo, Qi Pan   +5 more
wiley   +1 more source

The cholinergic basal forebrain and its role in neurodegeneration. [PDF]

J Neuropathol Exp Neurol
Cykowski MD, Masdeu JC.
europepmc   +1 more source

Inactivation Strategies of Clostridium perfringens in Foods: Current Challenges and Emerging Interventions

Food Frontiers, Volume 7, Issue 3, May 2026.
Clostridium perfringens forms heat‐resistant spores that complicate food safety. Physical methods (thermal processing, HPP, vacuum cooling, ozone treatments) and chemical interventions (natural antimicrobials, phosphates, nitrate/nitrite, organic acids) reduce vegetative cells and spores, though spore resistance remains a major challenge in food and ...
Deepak Subedi, Bharath Mallavarapu, Pranita Patil, Sujitha Bhumanapalli, Sandesh Chapagain, Kham Bahadur Khatri, Milan Kandel, Amit Kumar Singh   +7 more
wiley   +1 more source

Relationship of cholinergic basal forebrain atrophy with the time course of Alzheimer's disease pathology and cognitive decline in adults with Down syndrome: a longitudinal cohort study. [PDF]

Alzheimers Dement
Russell JK, Schlachetzki Z, Conley AC, Boyd BD, Newhouse PA, Aisen PS, Rafii MS, Alzheimer's Biomarker Consortium on Down Syndrome Study.   +7 more
europepmc   +1 more source

The Role of Nootropic Supplements in Sports: Enhancing Cognitive and Physical Performance Simultaneously

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
The review examines the nootropic effects of substances used in sports through their impact on neurotransmission, neuroendocrine control, energy production, synaptic plasticity, and neurovascular connections. The four key neurotransmitters dopamine, acetylcholine, serotonin, and GABA function to control motivation, attention, fatigue perception, and ...
Zheng Yi
wiley   +1 more source

Brain atrophy and cholinergic denervation in progressive supranuclear palsy: an MRI and [¹⁸F]-FEOBV PET study. [PDF]

Front Neurosci
Kanel P, Roytman S, Carli G, Vangel R, Barr J, Michalakis F, Spears CC, Scott PJH, Albin RL, Bohnen NI.   +9 more
europepmc   +1 more source