Cholinergic Antagonists and Behavioral Disturbances in Neurodegenerative Diseases [PDF]
International Journal of Molecular Sciences, 2023 Cholinergic antagonists interfere with synaptic transmission in the central nervous system and are involved in pathological processes in patients with neurocognitive disorders (NCD), such as behavioral and psychological symptoms of dementia (BPSD). In this commentary, we will briefly review the current knowledge on the impact of cholinergic burden on ...
Rachid Mahmoudi +2 more
exaly +6 more sources
Effects of cholinergic antagonists on ghrelin release and expression in the crop, proventriculus, and duodenum of newly hatched chickens [PDF]
Frontiers in PhysiologyThe aim of this study was to evaluate the effect of the cholinergic receptor antagonists on ghrelin (GHRL) expression and release from parts of the gastrointestinal system in an unique animal model—newly hatched chickens.
Colin Guy Scanes +2 more
doaj +4 more sources
Effects of Cholinergic and Opioid Antagonists on In Vitro Release of Met-Enkephalin, Somatostatin and Insulin-like Growth Factor-1 by and PENK Expression in Crop, Proventriculus and Duodenum of Newly Hatched Chickens [PDF]
AnimalsThe gastrointestinal (GI) tract is under neural, endocrine and paracrine control. The release (basal and in the presence of either cholinergic and opioid antagonists) of Met-enkephalin, insulin-like growth factor 1 (IGF-1) and somatostatin (SRIF) was ...
Colin G. Scanes +3 more
doaj +3 more sources
Characterizing the Access of Cholinergic Antagonists to Efferent Synapses in the Inner Ear [PDF]
Frontiers in Neuroscience, 2021 Stimulation of cholinergic efferent neurons innervating the inner ear has profound, well-characterized effects on vestibular and auditory physiology, after activating distinct ACh receptors (AChRs) on afferents and hair cells in peripheral endorgans ...
Choongheon Lee +8 more
doaj +2 more sources
Cholinergic Mechanisms in Spinal Locomotion - Potential Target for Rehabilitation Approaches
Frontiers in Neural Circuits, 2014 Previous experiments implicate cholinergic brainstem and spinal systems in the control of locomotion. Our results demonstrate that the endogenous cholinergic propriospinal system, acting via M2 and M3 muscarinic receptors, is capable of consistently ...
L M Jordan +9 more
doaj +2 more sources
Rapid Desensitization with Autologous Sweat in Cholinergic Urticaria
Allergology International, 2011 Background: The majority of patients with cholinergic urticaria presents with strong hypersensitivity to autologous sweat. Patients with severe cholinergic urticaria are frequently resistant to H1 antagonists which are used in conventional therapies for ...
Takeshi Kozaru +7 more
doaj +2 more sources
Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals [PDF]
Journal of Veterinary Pharmacology and Therapeutics, 2002 Oxindole alkaloids in the paraherquamide/marcfortine family exhibit broad‐spectrum anthelmintic activity that includes drug‐resistant strains of nematodes. Paraherquamide (PHQ), 2‐deoxoparaherquamide (2DPHQ), and close structural analogs of these compounds rapidly induce flaccid paralysis in parasitic nematodesin vitro, without affecting adenosine ...
Erich Zinser +8 more
openalex +3 more sources
Coordinated release of ATP and ACh from cholinergic synaptosomes and its inhibition by calmodulin antagonists [PDF]
, 1987 Isolated cholinergic synaptosomes from elasmobranch electric organ release both ACh and ATP when depolarized in the presence of calcium. The conditions that trigger ATP release are the same as those known to stimulate neurosecretion.
Eugene J. Schweitzer
openalex +2 more sources
Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity
Frontiers in Immunology, 2021 Neurological and immunological signals constitute an extensive regulatory network in our body that maintains physiology and homeostasis. The cholinergic system plays a significant role in neuroimmune communication, transmitting information regarding the ...
Namrita Halder, Girdhari Lal
doaj +1 more source
Frontiers in Immunology, 2021 The cholinergic system is present in both bacteria and mammals and regulates inflammation during bacterial respiratory infections through neuronal and non-neuronal production of acetylcholine (ACh) and its receptors.
Leon Islas-Weinstein +9 more
doaj +1 more source