Results 31 to 40 of about 31,317 (345)
PLoS ONE, 2019 In early-onset generalized torsion dystonia, caused by a GAG deletion in TOR1A (DYT1), enhanced striatal cholinergic activity has been suggested to be critically involved. Previous studies have shown increased acetylcholine levels in the striatum of DYT1
Franziska Richter +3 more
doaj +1 more source
Unilateral mydriasis secondary to ipratropium bromide in a critically ill patient
Journal of Emergencies, Trauma and Shock, 2012 Unilateral dilated pupil in a critical patient under sedation is an important clinical sign that requires prompt evaluation. An exhaustive assessment must be performed, including neurological examination and imaging tests, and pharmacological causes must
Luciano Santana-Cabrera +4 more
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Clinics, 2014 OBJECTIVES: Primary hyperhidrosis usually affects the hands, armpits, feet and cranio-facial region. Sweating in other areas is common in secondary hyperhidrosis (after surgery or in specific clinical conditions). Oxybutynin has provided good results and
Marcelo Passos Teivelis +5 more
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A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation. [PDF]
PLoS ONE, 2012 BACKGROUND: Cocaine increases the level of endogenous dopamine (DA) in the striatum by blocking the DA transporter. Endogenous DA modulates glutamatergic inputs to striatal neurons and this modulation influences motor activity.
Alessandro Tozzi +14 more
doaj +1 more source
Evaluation of Different Combined Regimens in the Treatment of Cholinergic Urticaria
World Allergy Organization Journal, 2012 Background Cholinergic urticaria is uncommon and accounts for 10% of all young adults. To date, there is no effective therapy for cholinergic urticaria.Objective To determine the therapeutic efficacy of different drug combinations in the treatment of ...
Abdulghani M. Alsamarai, MD, PhD +2 more
doaj +1 more source
Marine Drugs, 2022 The α7 nicotinic acetylcholine receptor (nAChR) is widely distributed in the central and peripheral nervous systems and is closely related to a variety of nervous system diseases and inflammatory responses.
Yao Tan +5 more
doaj +1 more source
Otorhinolaryngological adverse effects of urological drugs
International Brazilian Journal of Urology, 2021 Purpose: To describe the otorhinolaryngological adverse effects of the main drugs used in urological practice. Materials and Methods: A review of the scientific literature was performed using a combination of specific descriptors (side effect, adverse ...
Nathalia de Paula Doyle Maia +2 more
doaj +1 more source
Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia
New England Journal of Medicine, 2021 The muscarinic receptor agonist xanomeline has antipsychotic properties and is devoid of dopamine receptor-blocking activity but causes cholinergic adverse events. Trospium is a peripherally restricted muscarinic receptor antagonist that reduces peripheral cholinergic effects of xanomeline. The efficacy and safety of combined xanomeline and trospium in
Brannan, Stephen K. +5 more
openaire +2 more sources
Journal of Pharmacological Sciences, 2008 Lung cancer is the leading cause of cancer death worldwide and new treatment strategies are clearly needed. The recent discovery that lung and other cancers synthesize and secrete acetylcholine (ACh) which acts as an autocrine growth factor suggests that
Therapy Pingfang Song, Eliot R. Spindel
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An oral selective M3 cholinergic receptor antagonist in COPD [PDF]
European Respiratory Journal, 2006 Cholinergic antagonists have been used since the early 1900s as bronchodilators for chronic obstructive pulmonary disease (COPD). The present study investigated whether an oral muscarinic M3-selective anticholinergic agent (OrM3) would provide an improved therapeutic advantage compared with an inhaled anticholinergic agent in patients with COPD.A 6 ...
S, Lu +5 more
openaire +2 more sources