Results 21 to 30 of about 29,186 (237)

Otorhinolaryngological adverse effects of urological drugs

International Brazilian Journal of Urology, 2021
Purpose: To describe the otorhinolaryngological adverse effects of the main drugs used in urological practice. Materials and Methods: A review of the scientific literature was performed using a combination of specific descriptors (side effect, adverse ...
Nathalia de Paula Doyle Maia, Karen de Carvalho Lopes, Fernando Freitas Ganança   +2 more
doaj   +1 more source

Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia

New England Journal of Medicine, 2021
The muscarinic receptor agonist xanomeline has antipsychotic properties and is devoid of dopamine receptor-blocking activity but causes cholinergic adverse events. Trospium is a peripherally restricted muscarinic receptor antagonist that reduces peripheral cholinergic effects of xanomeline. The efficacy and safety of combined xanomeline and trospium in
Brannan, Stephen K., Sawchak, Sharon, Miller, Andrew C., Lieberman, Jeffrey A., Paul, Steven M., Breier, Alan   +5 more
openaire   +2 more sources

Basic and Clinical Aspects of Non-neuronal Acetylcholine: Expression of Non-neuronal Acetylcholine in Lung Cancer Provides a New Target for Cancer

Journal of Pharmacological Sciences, 2008
Lung cancer is the leading cause of cancer death worldwide and new treatment strategies are clearly needed. The recent discovery that lung and other cancers synthesize and secrete acetylcholine (ACh) which acts as an autocrine growth factor suggests that
Therapy Pingfang Song, Eliot R. Spindel
doaj   +1 more source

An oral selective M3 cholinergic receptor antagonist in COPD [PDF]

European Respiratory Journal, 2006
Cholinergic antagonists have been used since the early 1900s as bronchodilators for chronic obstructive pulmonary disease (COPD). The present study investigated whether an oral muscarinic M3-selective anticholinergic agent (OrM3) would provide an improved therapeutic advantage compared with an inhaled anticholinergic agent in patients with COPD.A 6 ...
S, Lu, D D, Parekh, O, Kuznetsova, S A, Green, C A, Tozzi, T F, Reiss   +5 more
openaire   +2 more sources

Exploring Cholinergic Compounds for Peripheral Neuropathic Pain Management: A Comprehensive Scoping Review of Rodent Model Studies

Pharmaceuticals, 2023
Neuropathic pain affects about 7–8% of the population, and its management still poses challenges with unmet needs. Over the past decades, researchers have explored the cholinergic system (muscarinic and nicotinic acetylcholine receptors: mAChR and nAChR)
Edouard Montigné, David Balayssac
doaj   +1 more source

Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing

Advanced Science, EarlyView.
Wearable sweat sensing relies not only on chemical detection but also on controlled biofluid management. This Review integrates sweat physiology, induction strategies, and microfluidic sampling architectures, demonstrating how flux, transport, and refreshment shape measurement reliability.
Soyoung Shin, Wei Gao
wiley   +1 more source

Mutual control of cholinergic and low-threshold spike interneurons in the striatum

Frontiers in Cellular Neuroscience, 2016
The striatum is the largest nucleus of the basal ganglia and is crucially involved in action selection and reward processing. Cortical and thalamic inputs to the striatum are processed by local networks in which several classes of interneurons play an ...
Rasha eElghaba, Nicolas eVautrelle, Enrico eBracci   +2 more
doaj   +1 more source

Medical and non-medical interventions for post-operative urinary retention prevention: network meta-analysis and risk–benefit analysis

Therapeutic Advances in Urology, 2021
Aims: To assess the efficacy in lowering post-operative urinary retention, urinary tract infection and lower urinary tract symptoms and the incidence of adverse events among 12 interventions and to perform risk–benefit analysis.
Pokket Sirisreetreerux, Rujira Wattanayingcharoenchai, Sasivimol Rattanasiri, Oraluck Pattanaprateep, Pawin Numthavaj, Ammarin Thakkinstian   +5 more
doaj   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Developmental role of acetylcholinesterase in impulse control in zebrafish

Frontiers in Behavioral Neuroscience, 2015
Cellular and molecular processes that mediate individual variability in impulsivity, a key behavioural component of many neuropsychiatric disorders, are poorly understood.
Matthew O Parker, Matthew O Parker, Alistair James Brock, Ari eSudwarts, Muy-Teck eTeh, Muy-Teck eTeh, Fraser eCombe, Caroline Helen Brennan   +7 more
doaj   +1 more source